Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study

Moradi, Lida; Vasei, Mohammad; Dehghan, Mohammad Mehdi; Majidi, Mohammad; Farzad‐Mohajeri, Saeed; Bonakdar, Shahin

doi:10.1016/j.biomaterials.2017.02.022

Cited by 102 publications

(62 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We observed that scaffolds with higher amount of chitosan had better cell adhesion and cell proliferation. Additionally, gene expression analysis showed that the scaffolds with higher amount of chitosan had higher expression of cartilage‐specific genes . Therefore, employing biomaterials with different compositions for fabrication of blend scaffolds can be a smart approach to design constructs with optimal bulk properties.…”

Section: Effects Of Bulk Properties On Cellular Behaviormentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

Self Cite

301

200

View full text Add to dashboard Cite

Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

show abstract

Section: Effects Of Bulk Properties On Cellular Behaviormentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

Self Cite

301

200

View full text Add to dashboard Cite

show abstract

“…A degradação dos arcabouços foi determinada nos estudos pela avaliação da taxa de perda de peso da amostra em determinado tempo (3,15). A viabilidade celular e citotoxicidade pode ser observada utilizando kit LIVE/DEAD (1,16,17,25,27,30,45,51,57) e pelo teste MTT (25,58,59). O estudo de YUAN et al (2016)(1) cita que a viabilidade celular foi calculada utilizando a relação entre as células vivas e número total de células.…”

Section: Resultsunclassified

Engenharia no Século XXI - Volume 4

Tinô¹,

Batista²,

Fontes³

et al. 2019

View full text Add to dashboard Cite

show abstract

“…At each time point, supernatant medium was collected and used as extract with no further dilution. Adipose tissue‐derived mesenchymal stem cells were harvested from the rabbits according to the previously described protocol . Rabbit stem cells with passage 4 were used for cell culture analyses.…”

Section: Methodsmentioning

confidence: 99%

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Hydrogels possessing high mechanical strength and well-controlled properties are of utmost interest in bone tissue engineering. In the current study, a strong self-crosslinked hydrogel with variable properties has been developed from a combinatory composition of functionalized pectin and silk fibroin. Pectin chains underwent partial oxidation to be decorated with aldehyde functionalities. Later on, functionalized polysaccharide and protein were blended with different ratios, and corresponding variations in crystalline structure as well as in morphological, mechanical, and rheological properties have been monitored. Some theories have been used to better perceive the relation between blending ratio and hydrogel properties. Avrami equation based on time sweep rheological analysis elucidated that in sample with equivalent ratio of oxidized pectin and fibroin, the crystallization was highly delayed due to dominance of Schiff's base reaction. The Herschel-Bulkley model based on flow curve rheology test corroborated that aforesaid composition revealed the most noticeable shear thinning behavior and accordingly the strongest crosslinked network. Finally, rubber elastic theory based on dynamic mechanical analysis implied that said formulation possessed the highest crosslinking density due to higher availability of aldehyde to amine functionalities. Moreover, cell culture studies proved that P50 F50 sample prevailed over other compositions with respect to cell viability and function.

show abstract

Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study

Cited by 102 publications

References 87 publications

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Engenharia no Século XXI - Volume 4

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Contact Info

Product

Resources

About