2017
DOI: 10.4028/www.scientific.net/jbbbe.31.70
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Regeneration Mechanism of Full Thickness Cartilage Defect Using Combination of Freeze Dried Bovine Cartilage Scaffold - Allogenic Bone Marrow Mesenchymal Stem Cells - Platelet Rich Plasma Composite (SMPC) Implantation

Abstract: Cartilage defect has become serious problem for orthopaedic surgeon and patients because of its difficult healing that might occur when articular cartilage damage never reach subchondral layer. In this study, we used combination of freeze dried bovine cartilage (FDBC) scaffold, bone marrow mesenchymal stem cells (BM-MSCs), and platelet rich plasma (PRP) composite (SMPC) implanted in full thickness cartilage defect. This study is to explain its regeneration mechanism. This is true experimental research with pos… Show more

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Cited by 5 publications
(8 citation statements)
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“…This process is estimated to work with the mechanism of differentiation of intrinsic stem cells that occur when there is a defect in an organ. 25,32 This was consistent with a meta-analysis study conducted by Muhammad, et.al. where the study found that the efficacy of stem cell and secretome administration was obtained. 15 This is due to the way stem cells work through the paracrine mechanism so that with the right secretome it can work as if there was a stem cell itself.…”
Section: Discussionsupporting
confidence: 91%
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“…This process is estimated to work with the mechanism of differentiation of intrinsic stem cells that occur when there is a defect in an organ. 25,32 This was consistent with a meta-analysis study conducted by Muhammad, et.al. where the study found that the efficacy of stem cell and secretome administration was obtained. 15 This is due to the way stem cells work through the paracrine mechanism so that with the right secretome it can work as if there was a stem cell itself.…”
Section: Discussionsupporting
confidence: 91%
“…33 This study was also in line with previous studies conducted by Utomo, et.al. which was a progenitor of scaffold material used in this study. 25 The results from this study so far has favorable results compared with similar studies using synthesized scaffolds. 34,35 Figure 6.…”
Section: Discussionmentioning
confidence: 58%
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“…This biomaterial is cheap and easy to acquire. Bovine cartilage scaffold will not damage the stem cell [12].…”
Section: Introductionmentioning
confidence: 99%