Preparation of protein nanoparticle-coated poly(hydroxybutyrate) electrospun nanofiber based scaffold for biomedical applications

Du, Zhimin; Jia, Shuwei; Xiong, Ping; Cai, Zengxuan

doi:10.1080/00914037.2021.1876058

Cited by 4 publications

(9 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to bone and cartilage repair, a variety of common PHAs, such as PHB, 171,172,277–289 P4HB, 289 PHBV, 157,290–300 PHBHHx, 300 P34HB, 185,301 and PHBVHHx, 141 as shown in Table S4,† have shown good application value in the field of skin tissue engineering.…”

Section: Phas For Medical Applicationsmentioning

confidence: 99%

Polyhydroxyalkanoates: the natural biopolyester for future medical innovations

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Phas For Medical Applicationsmentioning

confidence: 99%

Polyhydroxyalkanoates: the natural biopolyester for future medical innovations

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The addition of graphene oxide (GO) nanosheets significantly enhanced the wettability of the surface of the PHBV biopolymer films [ 65 ]. The nanofiber PHB scaffold turned from hydrophobic into hydrophilic in surface characteristic with WCA decreasing from 124° to 44° upon addition of soybean protein nanoparticles (SPN) [ 66 ].…”

Section: The Most Important Properties Of the Hybrids Based On Phasmentioning

confidence: 99%

“…Addition of mechanically stable GO into the polymeric matrix bestowed the flexibility of the PHBV based Fe 3 O 4 /GO-g-PHBV composite enhancing tensile strength and elongation at break [ 90 ]. The ductility of the PHB nanofiber scaffold significantly improved with addition of 1 wt% SPN increasing the elongation at break by 190% compared to pure PHB scaffold [ 66 ].…”

Section: The Most Important Properties Of the Hybrids Based On Phasmentioning

confidence: 99%

“…Electrospun PHB/CTS fibrous scaffolds containing 15 wt% and 20 wt% CTS possessed an enhanced mass loss rate compared to pure PHB [ 32 ]. SPN have been shown to be able to accelerate the biodegradation rate of PHB nanofiber scaffold with weight loss percentage increasing from 14.4% to 30.4% after degradation for 30 days in enzyme solution [ 66 ]. It has been shown that addition of graphene nanoplatelets into PHB matrix led to decrease in the rate of degradation due to the non-degradable nature of graphene [ 89 ].…”

Section: The Most Important Properties Of the Hybrids Based On Phasmentioning

confidence: 99%

“…Electrospun PHB/PANi composite scaffold modified by air plasma and printed by an inkjet method enhanced the proliferation and migration of mouse fibroblast (L-929) and human dermal fibroblast cell lines [ 77 ]. SPN-modified PHB nanofiber scaffold presented better cytocompatibility, provided cell-substrate interactions favorable for better cell adhesion and proliferation of NIH3T3 mouse fibroblast cells and MG-63 human osteoblast cells [ 66 ].…”

Section: Pha Based Composites For Tissue Engineeringmentioning

confidence: 99%

See 2 more Smart Citations

Review of Hybrid Materials Based on Polyhydroxyalkanoates for Tissue Engineering Applications

Pryadko

Surmenev

2021

Polymers

View full text Add to dashboard Cite

This review is focused on hybrid polyhydroxyalkanoate-based (PHA) biomaterials with improved physico-mechanical, chemical, and piezoelectric properties and controlled biodegradation rate for applications in bone, cartilage, nerve and skin tissue engineering. PHAs are polyesters produced by a wide range of bacteria under unbalanced growth conditions. They are biodegradable, biocompatible, and piezoelectric polymers, which make them very attractive biomaterials for various biomedical applications. As naturally derived materials, PHAs have been used for multiple cell and tissue engineering applications; however, their widespread biomedical applications are limited due to their lack of toughness, elasticity, hydrophilicity and bioactivity. The chemical structure of PHAs allows them to combine with other polymers or inorganic materials to form hybrid composites with improved structural and functional properties. Their type (films, fibers, and 3D printed scaffolds) and properties can be tailored with fabrication methods and materials used as fillers. Here, we are aiming to fill in a gap in literature, revealing an up-to-date overview of ongoing research strategies that make use of PHAs as versatile and prospective biomaterials. In this work, a systematic and detailed review of works investigating PHA-based hybrid materials with tailored properties and performance for use in tissue engineering applications is carried out. A literature survey revealed that PHA-based composites have better performance for use in tissue regeneration applications than pure PHA.

show abstract