Reflex reading epilepsy: Effect of linguistic characteristics on spike frequency

Safi, Dima; Lassonde, Maryse; Nguyen, Dang Khoa; Denault, Carole; Macoir, Joël; Rouleau, Isabelle; Beland, Renée

doi:10.1016/j.yebeh.2011.01.030

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…A recent meta-analysis of cerebral activations during single word reading in fluent adult readers revealed that the left precentral gyrus was more activated when reading nonwords compared to words and the authors postulated that this region is implicated in phonological output computation [17] . The concurrence between our results in the current study and those from our previous one [10] confirms this hypothesis and sheds light on the ictogenesis of primary reading epilepsy. In our previous study, reading-induced spike frequency was significantly higher when the patient read stimuli involving the phonological reading pathway (which includes grapheme-to-phoneme conversion and phonological output computation) compared to the lexical reading pathway.…”

Section: Discussionsupporting

confidence: 92%

“…In a previous study aiming to better understand the pathophysiology of reading epilepsy, we investigated a 42-year-old right-handed French-speaking man with primary reading epilepsy, using clinical assessments and continuous video-EEG [10] . Results revealed a significantly higher epileptic activity during reading than during other verbal and nonverbal tasks.…”

Section: Introductionmentioning

confidence: 99%

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Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study

Safi

Beland

Nguyen

et al. 2016

Epilepsy & Behavior Case Reports

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PurposeIn a previous study, we investigated a 42-year-old male patient with primary reading epilepsy using continuous video-electroencephalography (EEG). Reading tasks induced left parasagittal spikes with a higher spike frequency when the phonological reading pathway was recruited compared to the lexical one. Here, we seek to localize the epileptogenic focus in the same patient as a function of reading pathway using multimodal neuroimaging.Methods and resultsThe participant read irregular words and nonwords presented in a block-design paradigm during magnetoencephalography (MEG), functional near-infrared spectroscopy (fNIRS), and functional magnetic resonance imaging (fMRI) recordings, all combined with EEG. Spike analyses from MEG, fNIRS, and fMRI–EEGs data revealed an epileptic focus in the left precentral gyrus, and spike localization did not differ in lexical and phonological reading.ConclusionThis study is the first to investigate ictogenesis in reading epilepsy during both lexical and phonological reading while using three different multimodal neuroimaging techniques. The somatosensory and motor control functions of the left precentral gyrus that are congruently involved in lexical as well as phonological reading can explain the identical spike localization in both reading pathways. The concurrence between our findings in this study and those from our previous one supports the role of the left precentral gyrus in phonological output computation as well as seizure activity in a case of reading epilepsy.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%