Reflectometric detection of influenza virus in human saliva using nanoimprint lithography-based flexible two-dimensional photonic crystal biosensor

Endo, Tatsuro; Ozawa, Shoji; Okuda, Norimichi; Yanagida, Yasuko; Tanaka, Satoru; Hatsuzawa, Takeshi

doi:10.1016/j.snb.2010.05.036

Cited by 74 publications

(54 citation statements)

References 38 publications

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“…The TMSMA and NAS moieties act as surface-reactive and amine-reactive groups, respectively, and poly(TMSMA-r-NAS) has frequently been used for binding a sensor matrix and protein ligands via the amine coupling reaction. [16][17][18] Anti-human hemoglobin monoclonal antibodies and purified human hemoglobin were purchased from Nippon Bio-Test Laboratories Inc. (Tokyo, Japan) and MP Biomedicals, LLC (Santa Ana, CA), respectively. Albumin from bovine serum (Sigma Co., St. Louis, MO) was used as a negative-control protein.…”

Section: Reagents and Materialsmentioning

confidence: 99%

Label-free Detection of Antigen Protein Using a Metal Mesh Device Surface-modified by an Antibody

et al. 2015

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A biosensor for protein detection was developed using antibody-immobilized metal mesh devices. Antihemoglobin antibodies were covalently immobilized on a metal mesh device. Extraordinary transmission with a dipped structure was observed for a metal mesh device immobilized with antihemoglobin antibodies as well as for the original metal mesh device. Hemoglobin in the mixture solution containing albumin at a hundred-fold concentration was detectable using antihemoglobin-immobilized MMDs. The detectability using the antihemoglobin-immobilized metal mesh device was similar to that of a commercially-available kit for the qualitative determination of hemoglobin.

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Section: Reagents and Materialsmentioning

confidence: 99%

Label-free Detection of Antigen Protein Using a Metal Mesh Device Surface-modified by an Antibody

et al. 2015

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“…50 These materials are often made from silica or indium oxide, carefully constructed and modified for their chemical and optical properties. [51][52][53][54][55][56][57] The optical properties of PCs are related to their periodicity, size, and average refractive index. 51 Sharma and Sharan 52,53 detected high glucose concentration in urine, known as glycosuria, using a PC-based structure with line defects and 2D air holes in a silicon slab.…”

Section: Pc-based Biosensorsmentioning

confidence: 99%

“…Endo et al 54 employed a 2D PC-based biosensor for the reflectometric detection of the influenza virus in human saliva. Nanoimprinting technology was used in the fabrication of this PC-based biosensor due to its low cost and high resolution.…”

Section: Pc-based Biosensorsmentioning

confidence: 99%

Nanomaterial-based biosensors for biological detections

Su¹,

Li²,

Jin³

et al. 2017

AHCT

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Nanomaterial-based biosensors have become one of the major topics in the field of diagnostics. With the growing demand on devices with improved sensitivity and selectivity, rapid response time, and low cost, four categories of nanomaterials have become popular in biosensor research: gold nanoparticles, graphene, carbon nanotubes, and photonic crystals. The ongoing research has brought new designs of biosensors based on nanomaterials, which have greatly improved the potential of field-deployable microfabricated devices. This review describes the recent technologies employing the aforementioned nanomaterials for electrochemical detection of biomolecules, including glucose, DNA, protein, toxins, and so on. We envisage that miniaturized lab-on-a-chip devices employing these nanomaterials will soon be an essential part of our daily life.

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“…By these specific reaction, the surrounding refractive index will be increased which depend on the fibrinogen concentrations. These increment of surrounding refractive index due to the antigenantibody reaction, the diffraction peak intensity-based on Bragg's law will be decreased based on Fresnel equations [9], [10], [13]. From these experimental procedure, fibrinogen concentration can be determined as a diffraction peak intensity change.…”

Section: Experimental Procedures For Detection Of Fibrinogenmentioning

confidence: 99%

“…To fabricate the polymerbased nanooptical biosensor cost effectively and rapidly, we have been using the nanoimprint lithography (NIL) [9]- [13]. Using NIL, nanooptical biosensor can be fabricated with high reproducibility and cost effectively.…”

Section: Introductionmentioning

confidence: 99%

Label-Free Optical Detection of Fibrinogen in Visible Region Using Nanoimprint Lithography-Based Two-Dimensional Photonic Crystal

Endo

Kajita²

2017

IEICE Trans. Electron.

Self Cite

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SUMMARYFor the future medical diagnostics, high-sensitive, rapid, and cost effective biosensors to detect the biomarkers have been desired. In this study, the polymer-based two-dimensional photonic crystal (2D-PC) was fabricated using nanoimprint lithography (NIL) for biosensing application. In addition, for biosensing application, label-free detection of fibrinogen which is a biomarker to diagnose the chronic obstructive pulmonary disease (COPD) could be achieved using antigen-antibody reaction high-sensitively (detection limit: pg/ml order) and rapidly. Using this polymer-based 2D-PC, optical biosensor can be developed cost effectively. Furthermore, by using polymer as a base material for fabrication of 2D-PC, label-free detection of antigen-antibody reaction can be performed in visible region.

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Reflectometric detection of influenza virus in human saliva using nanoimprint lithography-based flexible two-dimensional photonic crystal biosensor

Cited by 74 publications

References 38 publications

Label-free Detection of Antigen Protein Using a Metal Mesh Device Surface-modified by an Antibody

Label-free Detection of Antigen Protein Using a Metal Mesh Device Surface-modified by an Antibody

Nanomaterial-based biosensors for biological detections

Label-Free Optical Detection of Fibrinogen in Visible Region Using Nanoimprint Lithography-Based Two-Dimensional Photonic Crystal

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