Abstract:SUMMARYFor the future medical diagnostics, high-sensitive, rapid, and cost effective biosensors to detect the biomarkers have been desired. In this study, the polymer-based two-dimensional photonic crystal (2D-PC) was fabricated using nanoimprint lithography (NIL) for biosensing application. In addition, for biosensing application, label-free detection of fibrinogen which is a biomarker to diagnose the chronic obstructive pulmonary disease (COPD) could be achieved using antigen-antibody reaction high-sensitive… Show more
“…The polymer-based template—fabricated using NIL—was used to fabricate the PC. Using this design of polymer-based template, we developed a nanophotonic-based biosensor based on a photonic crystal (PhC) [ 26 , 27 , 28 , 29 , 30 , 31 ]. In addition, using this polymer-based template mold, the metallic layer deposited can be peeled off easily.…”
Section: Methodsmentioning
confidence: 99%
“…By using a polymer-based template for fabrication of SERS active substrate, SERS active substrate can be fabricated with high reproducibility by changing the polymer-based template. We have fabricated polymer-based nanostructures using NIL to develop nanophotonics-based biosensors that operate in the visible region [ 26 , 27 , 28 , 29 , 30 , 31 ]. The surface energy of a polymer is generally low.…”
Surface-enhanced Raman scattering (SERS) is a potential candidate for highly sensitive detection of target molecules. A SERS active substrate with a noble metal nanostructure is required for this. However, a SERS active substrate requires complicated fabrication procedures. This in turn makes it difficult to fabricate highly sensitive SERS active substrates with high reproducibility. To overcome this difficulty, a plasmonic crystal (PC) with periodic noble metal nanostructures was fabricated via the template-stripping method using a polymer-based template. Using SERS active substrates, SERS was successfully achieved using the PC by detecting low concentrations of phenobarbital which is an antiepileptic drug using a commercially available portable Raman module. The PC can be fabricated by demolding the deposited gold layer from a polymer-based template. This method is rapid, economic, and has high reproducibility. SERS can be achieved easily using this PC for a wide variety of applications such as medical, pharmaceutical, and environmental protection.
“…The polymer-based template—fabricated using NIL—was used to fabricate the PC. Using this design of polymer-based template, we developed a nanophotonic-based biosensor based on a photonic crystal (PhC) [ 26 , 27 , 28 , 29 , 30 , 31 ]. In addition, using this polymer-based template mold, the metallic layer deposited can be peeled off easily.…”
Section: Methodsmentioning
confidence: 99%
“…By using a polymer-based template for fabrication of SERS active substrate, SERS active substrate can be fabricated with high reproducibility by changing the polymer-based template. We have fabricated polymer-based nanostructures using NIL to develop nanophotonics-based biosensors that operate in the visible region [ 26 , 27 , 28 , 29 , 30 , 31 ]. The surface energy of a polymer is generally low.…”
Surface-enhanced Raman scattering (SERS) is a potential candidate for highly sensitive detection of target molecules. A SERS active substrate with a noble metal nanostructure is required for this. However, a SERS active substrate requires complicated fabrication procedures. This in turn makes it difficult to fabricate highly sensitive SERS active substrates with high reproducibility. To overcome this difficulty, a plasmonic crystal (PC) with periodic noble metal nanostructures was fabricated via the template-stripping method using a polymer-based template. Using SERS active substrates, SERS was successfully achieved using the PC by detecting low concentrations of phenobarbital which is an antiepileptic drug using a commercially available portable Raman module. The PC can be fabricated by demolding the deposited gold layer from a polymer-based template. This method is rapid, economic, and has high reproducibility. SERS can be achieved easily using this PC for a wide variety of applications such as medical, pharmaceutical, and environmental protection.
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