Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon

Hansson, Anders; Zelada, Julio C.; Noriega, Hugo P.

doi:10.1016/j.jep.2004.12.029

Cited by 29 publications

(14 citation statements)

References 14 publications

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“…During diets a teaspoon of the fresh latex is administered, and occasionally a decoction of the bark and trunk is also given, having purely purgative effects. This is a highly toxic medicine-in fact, many cases of intoxication have been registered in the city of Pucallpa (Hansson et al, 2005) and the surrounding areas, mainly due to the high doses administered by false and unspecialized healers. During the diet, healers recommend the observance of the following restrictions: isolation, partial or total fasting (depending on the healer), and sexual abstinence; and they often recommend the additional restriction of avoiding direct exposure to sunlight, which could have adverse consequences.…”

Section: Purification and Cleansingmentioning

confidence: 99%

“Plantas con madre”: Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon

Jauregui

Clavo

Jovel

et al. 2011

Journal of Ethnopharmacology

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Section: Purification and Cleansingmentioning

confidence: 99%

“Plantas con madre”: Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon

Jauregui

Clavo

Jovel

et al. 2011

Journal of Ethnopharmacology

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“…Ficus (Moraceae) are being used traditionally in a wide variety of ethnomedical remedies all over the world [25].…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging, Proteases Activities, and Phenolics Composition of Bark Extracts from 21 Medicinal Plants

Raza

Shahwar

Khan

2015

Journal of Chemistry

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Stem barks derived from twenty-one medicinal plants were extracted in methanol (100%) and acetone-water (70 : 30 v/v) and at room as well as at reflux temperature conditions. Total phenolic contents, determined using FC (Folin Ciocalteu) reagent, ranged from 528 to 715 mg GAE/g of crude extract. 15 out of 21 plants showed DPPH activity more than 90% and the rest of plants exhibited the activity in the range of 87–89%. The methanolic extract ofP. granatumobtained at room temperature showed the highest antiradical activity (96%). The extracts with similar % radical scavenging of DPPH∙showed significant variation in EC50value. Radical scavenging activity ofE. rostrata, M. champaca, A. modesta, P. roxburghii, P. longifolia, E. suberosa,andF. infectoriawas evaluated for the first time. A strong correlation between total phenols and antiradical activity was exhibited withRvalues ranging from 0.7580 to 0.8874 indicating a linear relationship The extracts phenolic composition was studied by HPLC. All extracts showed remarkable antioxidant activity (87 to 96%) while moderate activity was exhibited against protease (22 to 56%). Gallic acid, tannic acid, quercetin, rutin, catechin, hesperidin, and cinnamic acid were identified as the major phenolic acids in the extracts of selected medicinal plants.

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“…They are found in all tropical habitat types, with about 100 species occurring in Africa and the surrounding islands [15]. Several species of the genus Ficus are used traditionally in a wide variety of ethnomedical remedies all over the world [16,17]. They have long been used in folk medicine as antidiabetic, anthelmintic, hypotensive, mild laxative, antirheumatic, digestive and anti-dysentery drugs [18,19].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of extracts of ten African Ficus species (Moraceae) used traditionally to treat diabetes

Olaokun

McGaw

Eloff

et al. 2013

BMC Complement Altern Med

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BackgroundSome Ficus species have been used in traditional African medicine in the treatment of diabetes. The antidiabetic potential of certain species has been confirmed in vivo but the mechanism of activity remains uncertain. The aim of this study was to determine the activity and to investigate the mechanism of antidiabetic activity of ten selected Ficus species through inhibition of α-amylase and α-glucosidase activity, and the possible relationship between these activities, the total polyphenolic content and the antioxidant activity.MethodsDried acetone leaf extracts were reconstituted with appropriate solvents and used to determine total polyphenolic content antioxidant activity, α-amylase and α-glucosidase inhibitory activity.ResultsThe crude acetone extract of F. lutea had the highest polyphenolic content (56.85 ± 1.82 mg GAE/g of dry material) and the strongest antioxidant activity with a TEAC value of 4.80 ± 0.90. The antioxidant activity of the acetone extracts of the Ficus species may not be ascribed to total polyphenolic content alone. The crude extract at a concentration of 0.5 mg/ml of F. lutea (64.3 ± 3.6%) had the best α-glucosidase (sucrase) inhibitory activity. The EC50 of F. lutea (290 ± 111 μg/ml) was not significantly different from that of F. sycomorus (217 ± 69 μg/ml). The α-amylase inhibitory activity of F. lutea (95.4 ± 1.2%) at a concentration of 1 mg/ml was the highest among the Ficus species screened. The EC50 for F. lutea (9.42 ± 2.01 μ g/ml), though the highest, was not significantly different (p < 0.05) from that of F. craterostoma and F. natalensis. It was apparent that the crude acetone extract of F. lutea is a partially non-competitive inhibitor of α-amylase and α-glucosidase. Based on correlation coefficients polyphenolics may be responsible for α-glucosidase activity but probably not for α-amylase activity.ConclusionAntidiabetic activity potential via inhibition of α-amylase and α-glucosidase was discovered in Ficus lutea which has not been previously reported. The acetone extract of the leaves was high in total polyphenolic content and antioxidant activity, and was a potent inhibitor of α-amylase activity. Research is underway to isolate the active compound(s) responsible for the antidiabetic activity and to confirm the in vitro antidiabetic activity and to investigate in vitro toxicity.

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Reevaluation of risks with the use of Ficus insipida latex as a traditional anthelmintic remedy in the Amazon

Cited by 29 publications

References 14 publications

“Plantas con madre”: Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon

“Plantas con madre”: Plants that teach and guide in the shamanic initiation process in the East-Central Peruvian Amazon

Radical Scavenging, Proteases Activities, and Phenolics Composition of Bark Extracts from 21 Medicinal Plants

Evaluation of the inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of extracts of ten African Ficus species (Moraceae) used traditionally to treat diabetes

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