Reduction of Post-Surgical Adhesion Formation with Tranilast

Abdominal Adhesions: Current and Novel Therapies

“…Product combination superior to either component in rabbit model [268] Systemic administration of drug ineffective in rabbits [268] Later formulations combine this product in a sodium carboxymethylcellulose aqueous gel [298] Carboxymethylcellulose (CMC), poly(ethylene oxide) (PEO), þ calcium (Oxiplex) Film and gel forms have shown efficacy in animals (pigs, rabbits, rats) [299] Some efficacy in humans [179,300] CMC functions as tissue-adherent barrier [176,181,299] PEO hinders protein deposition onto tissue surfaces [181,301]. Calcium controls rheology [181] Crosslinked hyaluronan hydrogel þ covalently bound mitomycin C More effective in rat model than crosslinked hyaluronan films alone [302] Mitomycin C is an antibiotic that inhibits DNA synthesis; may prevent adhesion formation by killing pro-adhesion cells or preventing cell migration to potential adhesion site May impact wound healing Electrospun poly(lactide-co-glycolide) (PLGA) nonwoven nanofibrous membranes þ cefoxitin (antibiotic)…”

“…Some efficacy in rabbit models [268] Transilast is mast cell stabilizer [ Decrease estrogen levels; believe to alter fibrinolysis and extracellular matrix remodeling [270] Some efficacy in rat and primate models [270][271][272] Ineffective in reducing severity and extent of adhesions in women (n ¼ 20) [273] Aromatase inhibitors (tamoxifen, anastrozole)…”

Modeling of the Adsorption of Organic Compounds on Polymeric Nanofiltration Membranes in Solutions Containing Two Compounds

“…PPDO also exhibits good mechanical performance with high tensile strength and excellent flexibility, which make it a good candidate for universal uses, such as films, molded products, laminates, foams, non‐woven materials, and adhesives. Accordingly, PPDO has attracted the interest of researchers on its synthesis,5–11 properties,12–20 and applications21, 22 in recent years. However, PPDO has no distinct advantage on mechanical strength while it compares with commercialized aliphatic polyester polylactide (PLA).…”

Fibrin‐targeted block copolymers for the prevention of postsurgical adhesions

“…21 All methods were approved and performed in accordance with the guidelines set by the University of Kentucky Institutional Animal Care and Use Committee. Although a variety of methods of adhesion induction are available, [22][23][24][25][26][27][28][29] previous work has demonstrated that a ''double injury'' wound induction method allows for standardization of the type and extent of adhesions. 30 Administration and subsequent scoring of animals were done in a blinded fashion to control for operator bias.…”