Abdominal Adhesions: Current and Novel Therapies

Ward, Brian; Panitch, Alyssa

doi:10.1016/j.jss.2009.09.015

Cited by 211 publications

(224 citation statements)

References 259 publications

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“…In a rat septic peritonitis model, lidocaine hydrochloride solution was an effective prophylaxis against adhesion, probably due to blocking the development of oxidative stress (Brocco et al 2008, Yuzbasioglu et al 2008Arung et al 2011;Ward and Panitch 2011). In another study, lidocaine was effective for the treatment of peritonitis, while NaCl 0.9% minimally affected adhesion formation (Gallos et al 2004).…”

Section: Discussionmentioning

confidence: 97%

“…Formation of adhesions may affect convalescence and future production and reproduction of the animals with high genetic potential (Teixeira et al 2011;Ward and Panitch 2011). Adhesions occur due to peritoneal inflammation following surgical manipulation or infection, leading to an imbalance between fibrin deposition and degradation.…”

mentioning

confidence: 99%

“…Adhesions occur due to peritoneal inflammation following surgical manipulation or infection, leading to an imbalance between fibrin deposition and degradation. Fibrinous exudate may be reabsorbed by the animal without adhesion formation or reorganize follow-doi: 10.17221/8414-VETMED ing migration of fibroblasts, becoming permanent fibrosis (Arung et al 2011;Ward and Panitch 2011).…”

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confidence: 99%

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Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Mariano¹,

Uscategui²,

Nociti³

et al. 2015

Vet. Med. - Czech

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Adhesion formation involving the genitourinary tract is common following laparoscopic procedures. To evaluate the effectiveness of intraperitoneal lidocaine hydrochloride 1% solution for the prevention of abdominal adhesions, twenty four Santa Ines ewes submitted to laparoscopic ovum pick-up, uterine puncture and local rinsing, were randomly distributed into two groups of 12 animals, according to rinsing solution: normal saline (SG) or 1% lidocaine hydrochloride solution (LG). Laparoscopy for manipulation of the reproductive tract (uterine puncture trauma model and ovum pick-up) was applied. A standard laparoscopic approach using three ports in triangulation was employed. The uterus and ovaries were rinsed at the end of the procedure (using either saline or lidocaine hydrochloride) for removal of blood clots from the ovaries and uterine horn surfaces. Inflammation was assessed postoperatively by plasma fibrinogen, and all animals underwent a second laparoscopic procedure 21 days after surgery for macroscopic assessment of adhesion formation. Four cases of adhesion were observed in each group. The plasma fibrinogen did not differ between groups and among different time points, indicating an absence of systemic inflammation following laparoscopic procedures. There were no significant differences between treatments. Both normal saline and 1% lidocaine hydrochloride were similarly effective in the prevention of adhesion formation.Keywords: reproduction; endosurgery; ovary; uterus; laparoscopic; sheep List of abbreviations ET = embryo transfer, LOPU = laparoscopic ovum pick-up, LAI = laparoscopic artificial insemination, LG = lidocaine group, SG = normal saline (0.9% NaCl) group

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

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confidence: 99%

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Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Mariano¹,

Uscategui²,

Nociti³

et al. 2015

Vet. Med. - Czech

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“…But over the course of the experiment, to try to prevent adhesions, the abdominal cavity was washed using saline solution (NaCl 0.9%) added to lidocaine 2%, as this local anesthetic has been awarded as one of the drugs that act on prevention of adhesions, for its possible antiinflammatory effect (Ward and Panitch 2011). However, we could not avoid them.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic ovum pick-up in spotted paca ( Cuniculus pacas )

Barros

Teixeira

Uscátegui

et al. 2016

Arq. Bras. Med. Vet. Zootec.

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The aim of this work is study the laparoscopic ovum pick-up (LapOPU) technique in spotted paca, describing surgery details, complications and oocyte recovery rate. Nine healthy adult non-pregnant captive females were used, in a total of 39 procedures. When the surgical plane of anaesthesia was achieved, the females were positioned at 20º Trendelenburg. Three 6mm trocars were placed on right and left inguinal and hypogastric regions. Abdomen was inflated with CO 2 and the intra-abdominal pressure was stablished in 10mmHg. Follicular punctures were performed moving the ovaries with atraumatic forceps. For punctures, an 18-gauge 3.5 inch long needle attached to a vacuum system with pressure not exceeding 65mmHg was used. Oocytes were recovered into 50mL centrifuge tubes with media composed of PBS supplemented with 10 IU/mL of heparin and kept at 36°C. R Software was used for statistical analysis. Data normality distribution (Shapiro test) and variances homoscedasticity (Bartlett test) were tested and descriptive statistics (mean±SD) was used to present the results. It was only possible to perform LapOPU in 30 of 39 laparoscopies (76.92%). The surgical total time was 37.34 ± 18.53 minutes. The total number of visualized follicles, aspirated follicles, and retrieved oocytes were 502, 415, and 155, respectively. And the same parameters per animal were: 14.34 ± 12.23, 11.86 ± 10.03, and 4.43 ± 4.69 respectively. Oocyte recovery rate was 32.56 ± 27.32%. In conclusion, caudal positioning of portals with slight triangulation allows good viewing of the abdominal cavity and eases the manipulation of the ovaries. Thus this described LapOPU technique is feasible in spotted paca and easy to perform. 34 ± 12,23, 11,86 ± 10,03 e 4,43 ± 4,69, respectivamente Keywords

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“…Protection of wounded surfaces with various materials had been proposed to overcome this condition, including absorbable patches [9], gels [10], or some liquids such as icodextrin [11]. All three types of adhesion barriers have limited approval by the United States Food and Drug Administration [6,12].…”

Section: Discussionmentioning

confidence: 99%

Comparison of 4 % Icodextrin and Omega 3 Fatty Acids in Prevention of Peritoneal Adhesions

Karakaş¹,

Yigitler

Güleç

et al. 2012

Indian J Surg

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Postoperative peritoneal adhesions are major concerns in abdominal surgery. In this experimental study, the effects of 4 % icodextrin and omega-3 fatty acids (ω-3 FA) on prevention of postoperative peritoneal adhesions were evaluated. Twenty-four Wistar albino rats were divided into three groups. After laparotomy, serosal abrasion was carried out by cecal brushing. Intraperitoneally 3 cm 3 0.9 % NaCl, 3 cm 3 4 % icodextrin, and 200 mg/kg ω-3 FAs for each group were applied, and then the abdomen was closed. All subjects sacrificed 10 days postoperatively. Macroscopic and histopathological cellular reactions as a function of giant cell, lymphocyte/plasmocyte, neutrophil, histiocyte, intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cell adhesion molecule-1 (PECAM-1) were assessed and hydroxyproline levels were measured in all three groups and compared using Kruskal-Wallis and ANOVA tests when appropriate. Macroscopically, both ω-3 FAs and 4 % icodextrin reduced adhesion formation but the difference was not statistically significant (P00.253). Histopathological examination revealed that there was no statistical significance in terms of giant cell, lymphocyte/plasmocyte, neutrophil, ICAM-1, and PECAM-1 scores; however, both ω-3 FAs and 4 % icodextrin were found to be prone to reduce fibrosis (P00.047), whereas in the ω-3 FA group, histiocytic reaction was significantly increased (P00.001), and hydroxyproline levels were significantly lower than other groups (P00.044). In this study, ω-3 FAs were found to be superior to 4 % icodextrin with the lower hydroxyproline level and greater histiocytic reaction. Considering these results, ω-3 FAs can be a promising agent in the prevention of adhesion formation.

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Abdominal Adhesions: Current and Novel Therapies

Cited by 211 publications

References 259 publications

Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Laparoscopic ovum pick-up in spotted paca ( Cuniculus pacas )

Comparison of 4 % Icodextrin and Omega 3 Fatty Acids in Prevention of Peritoneal Adhesions

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