Reduction of Mortality from X-Radiation by Treatment with Antibiotics

Further Efforts to Influence X-Ray Cataract by Chemical Agents

“…(1,2) and on sulfhydryl enzymes (3-8) have shown clearly that the effectiveness of the radiation is decreased in the presence of other solutes, that is, that chemical agents can protect irradiated compounds against X-ray effects. Similar studies have been extended by other workers to such biologic material as bacteria (9, io) and small laboratory animals (9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). The relative protection of these living systems against X-ray damage by the introduc-…”

Relation Between Bacteremia and Death in Mice Following X-Ray and Thermal Column Exposures

“…After an additional 48 hours of incubation, they were streaked on blood agar plates and a final reading was made. Anaerobic cultures were not done, as Miller et al (1950aMiller et al ( , 1950b have reported no significant number of anaerobes present in mice after radiation.…”

“…Numerous investigators have studied the efficacy of antibiotics in the treatment of postirradiation infection (Howland et al, 1949;Miller et al, 1950bMiller et al, , 1952Furth et ca., 1951). William and Congdon (1952) were able to modify infection after 900 r with bone marrow injection.…”

Chlorisondamine, a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge

“…Similar risks would be associated with victims of nuclear disaster (e.g., the recent meltdown in Fukushima, Japan [2]) or acts of nuclear terrorism [3]. In experimental models, radiation-induced mortality has long been associated with enteric bacterial infection [4][5][6] and survival was found to be enhanced through the use of antibiotics [7][8][9].…”