Relation Between Bacteremia and Death in Mice Following X-Ray and Thermal Column Exposures

Boone, Irene U.; Woodward, Kent T.; Harris, P.S.

doi:10.1128/jb.71.2.188-195.1956

Cited by 12 publications

(1 citation statement)

References 17 publications

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“…65 For example, bacterial infection is the predominate factor leading to RID in mice at doses near their respective LD 50 levels. [65][66][67] However, recent results from Krigsfeld et al have indicated that radiation-induced coagulopathy (RIC) and clinical sequelae that mimic disseminated intravascular coagulation (DIC) can result in hemorrhage, microvascular thrombosis, organ damage, and death from multiorgan failure from exposure of large animals (including ferrets and pigs) to doses of radiation at or near the species' LD 50 . [68][69][70][71][72] RIC-associated hemorrhage occurs well before the expected decline in peripheral platelet counts after irradiation.…”

Section: Animal Model Sensitivity and Dose Simulationmentioning

confidence: 99%

Limitations in predicting the space radiation health risk for exploration astronauts

et al. 2018

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Despite years of research, understanding of the space radiation environment and the risk it poses to long-duration astronauts remains limited. There is a disparity between research results and observed empirical effects seen in human astronaut crews, likely due to the numerous factors that limit terrestrial simulation of the complex space environment and extrapolation of human clinical consequences from varied animal models. Given the intended future of human spaceflight, with efforts now to rapidly expand capabilities for human missions to the moon and Mars, there is a pressing need to improve upon the understanding of the space radiation risk, predict likely clinical outcomes of interplanetary radiation exposure, and develop appropriate and effective mitigation strategies for future missions. To achieve this goal, the space radiation and aerospace community must recognize the historical limitations of radiation research and how such limitations could be addressed in future research endeavors. We have sought to highlight the numerous factors that limit understanding of the risk of space radiation for human crews and to identify ways in which these limitations could be addressed for improved understanding and appropriate risk posture regarding future human spaceflight.

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