Reducing the risk of infection for transrectal prostate biopsy with povidone–iodine: a systematic review and meta-analysis

Abstract

Rectal disinfection with PI provides a safe and effective method to reduce the risk of infectious complications following TRPB, regardless of mono-prophylaxis and combined prophylaxis with PI and ATB. Large, multicenter, and prospective RCTs of good quality trials are needed to confirm the efficacy of PI.

Complications of Transrectal Ultrasound-Guided Prostate Biopsy: Impact of Prebiopsy Enema

“…A significant decrease in infectious complications (p=0.001) was observed in patients who received an enema. These collective prior results [13,14,15,16] indicate that a prebiopsy povidone-iodine enema could reduce the risk of infectious complications after TRUS-guided prostate biopsy. We summarized and compared the results of prior studies with those of our study in Table 3.…”

Transrectal prostate biopsy sepsis rate following reduced quinolone antibiotic prophylaxis from six doses to single dose

“…Other approaches and practices that have been studied include rectal cleansing, enemas and disinfectants. The literature remains inconclusive on the effectiveness of these strategies in reducing infective complication post‐TRPB . Similarly, there has been no evidence to suggest that disinfecting biopsy needles reduce TRPB‐related infections .…”

DEGUM Recommendations on Infection Prevention in Ultrasound and Endoscopic Ultrasound

“…Eine Metaanalyse über sieben Studien und 2049 Patienten fand eine signifikante relative Risikoreduktion für Fieber und Bakteriämie, wenn die Antibiotikagabe mit rektalen Einläufen mit Povidon-Jodlösung kombiniert wurde [101]. In einer nicht in diese Analyse eingeschlossenen prospektiven randomisierten Studie an 865 Männern konnte nur eine tendenzielle, aber keine signifikante Senkung von infektiösen Komplikationen von 3,5 auf 2,6 % beobachtet werden [102].…”