Transrectal prostate biopsy sepsis rate following reduced quinolone antibiotic prophylaxis from six doses to single dose

Abstract

Our study supports the use of a single dose of ciprofloxacin as sufficient antibiotic prophylaxis prior to TRPB.

Transrectal ultrasound biopsy of the prostate: does it still have a role in prostate cancer diagnosis?

“…The duration of pre-biopsy fluoroquinolone prophylaxis appears unrelated to infection risk. Bangash and colleagues performed a prospective analysis of post-biopsy infection rates in 2018, and suggested that a single dose of ciprofloxacin 500 mg was non-inferior to a three-day course of twice daily ciprofloxacin in over 700 patients (31).…”

“…In 80 high-risk patients who received ertapenem, there were no cases of sepsis compared to a rate of 6.7% within the cohort who received ciprofloxacin and amoxicillin-clavulanate (35). In several Australian studies, carbapenem use has been associated with a zero-sepsis rate (31,36). Despite the apparent reduction in TRUS biopsy related infection, the use of carbapenems should be minimised where possible due to the threat of Enterobacteriaceae carbapenemresistance.…”

‘One Stop Prostate Clinic’: prospective analysis of 1000 men attending a public same‐day prostate cancer assessment and/or diagnostic clinic

“…The risk of infection complicating TRUS prostate biopsies is reduced with appropriate antibiotic prophylaxis 18 . We have previously reported the comparison of infective complication rates following the change in the prophylactic antibiotic regimen, 19 now updated to include all men (876 out of 1000) who had a TRUS prostate biopsy. The increase in infective complications was not statistically significant.…”