Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

Cioca, Gabriela; Agop, Maricel; Popa, Marcel; Bungău, Simona; Butuc, Irina

doi:10.37358/rc.17.12.6008

Cited by 4 publications

(4 citation statements)

References 20 publications

(30 reference statements)

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“…The drug release rate depends on factors like: drug composition (stability, interaction with matrix, solubility), material matrix (degradation, structure, composition, swelling,), and release medium (ionic strength, pH, enzymes, temperature) [25][26][27]. To formulate unit doses and other pharmaceutical products the most commonly used are cellulose and cellulose derivatives.…”

Section: Results An Discussionmentioning

confidence: 99%

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

Moisa¹,

Ţiţ²,

Uivaroșan³

et al. 2020

Rev. Chim.

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Modern lifestyle, excessive chemicalization of agricultural products, excessive processing and refining of food, cause a decrease in daily intake of magnesium, cation with an extremely important role in prevention and treatment of many diseases. As a result, there arises the need for extra magnesium intake in the form of dietary supplements. In this study were evaluated the physical and chemical stability of magnesium-containing tablets, depending on the active compound and the excipients used. Magnesium tablets in the form of orotate, lactate, citrate, oxide and hydroxide were taken into study and physical and chemical stability were observed over the validity period, at 6 and at 12 months after expiry date. There were no changes in physical and chemical stability during the validity period of the studied tablets. At 6 months after the expiry date, were observed variations in chemical composition with decrease in magnesium concentration to 98% of the declared value, only in the case of tablets containing magnesium lactate. At 12 months, the magnesium concentration decreased in all analysed samples, with no statistically significant differences (p[0.05) between the types of magnesium compounds � 95% for the orotate, 93% for the lactate, 90% for the oxide and hydroxide, respectively 85% for citrate. The results of this study indicate the therapeutically safety for using these tablets 6 months after the expiry date.

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Section: Results An Discussionmentioning

confidence: 99%

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

Moisa¹,

Ţiţ²,

Uivaroșan³

et al. 2020

Rev. Chim.

Self Cite

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“…Innovation and development in the cosmetics industry determine a direction that promotes health before beauty [15][16][17].…”

Section: Resultsmentioning

confidence: 99%

Study on the Stability and Compatibility of the Cosmetic Products with Lavandula angustifolia Oil Kept in PPH Polypropylene Homopolymer Plastic Containers

Bogdan¹,

Endres²,

Pasca³

et al. 2019

Mat.Plast.

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The products used in cosmetic formulations are continuously diversifying as a result of researches in the field, which combine the healing and prevention of many skin conditions with the use of natural products such as vegetable extracts and essential oils. Testing the stability and compatibility of new or modified cosmetics is required to ensure that quality standards are met when stored in proper conditions for functionality and aesthetics, to preserve their chemical, microbiological and physical properties. In this study, the stability and compatibility of a new cosmetic product containing lavender essential oil in plastic container-plastic jar 100 mL PPH Polypropylene homopolymer (Moplen HP648T) is tested against the glass receptacle used as a control. The monitored parameters were organoleptic characteristics (appearance, color, fragrance), physicochemical (pH, density), under controlled temperature conditions, and the microbiological ones. The results of this study showed that the tested cosmetic product is compatible with the plastic container; data obtained were comparable with the organoleptic and physicochemical test results obtained in the case of the control sample stored at room conditions.

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“…EOs obtaines from a large variety of plants and herbs present powerfull antimycotic properties [21,22]. The microbial development as well as the biofilm development may be reduced through specific mechanisms using EOs and other phytochemicals [23][24][25][26][27]. Oregano essential oil has a mixture of compounds, very complex, the main components being terpenes usually mono-and sesquiterpenes.…”

Section: Sensitivity To Treatmentmentioning

confidence: 99%

The Effects of Oregano Oil on Fungal Infections Associated with Metabolic Syndrome

Ghitea¹,

Bungău²,

Ţiţ³

et al. 2020

Rev. Chim.

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This study aims to compare the evolution of mycosis associated with metabolic syndrome under allopathic treatment compared to phytotherapy using oregano essential oil. The study was conducted over a period of 6 months, on a total of 72 patients diagnosed with fungal infections associated with metabolic syndrome. The patients were divided into 3 groups, depending on the administered treatment: group 1: 24 patients who received allopathic treatment; group 2: 24 patients who received oregano oil treatment; group 3: control, which did not undergo any antifungal treatment. All three groups were subjected to specific diet therapy for mycosis. The patients were initially evaluated at 10 days after the begining of the treatment (to track mycotic disease evolution in the acute phase), at 60 days (to evaluate the recurrence of mycoses) and at 180 days to track recurrent disease. Most infections were acute (77.78%), the chronic ones representing only 5.56% of cases. There were also 12 cases with recurrent infections (16.67%), out of which 6 cases (8.33%) had previously shown resistance to Nystatin. In the 72 cases there was a sensitivity of 100.00% for oregano oil and Ketaconazolum, insignificantly higher than for Myconazolum (97.22%, p=0.157), but significantly higher than for Clotrimazolum and Nystatinum (94.44%, p=0.0437), Variconazole and Fluconazole (88.89%, p=0.0038) and Itraconazole (86.11%, p=0.0011). The results of this study showed an increased efficiency of oregano oil on the symptomatic and paraclinical improvement of mycotic infections in the study, both on short term and on long term, which was completed with high tolerability.

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Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

Cited by 4 publications

References 20 publications

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

Study on the Stability and Compatibility of the Cosmetic Products with Lavandula angustifolia Oil Kept in PPH Polypropylene Homopolymer Plastic Containers

The Effects of Oregano Oil on Fungal Infections Associated with Metabolic Syndrome

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