The administration of Mg 2+ determines not only the increase of Mg 2+ , but also induces changes in the tissular levels of Ca 2+ , K + and Na + . The effects of dietary Mg 2+ on macro-elements (Ca 2+ , K + , Na + ) levels in mice tissues (heart, liver, spleen, kidney and lung) were investigated in a murine study. Doses of 300, 200, 100, 50 and 25 mg of different Mg compounds (orotate, sulphate, oxide, chloride, carbonate, citrate) were administrated by gavage. The results showed that Na + and K + levels increase, while Ca 2+ levels decrease with the increase of the Mg 2+ level. In all organs, macro-elements levels decrease in the following order: K + > Na + > Ca 2+ . The highest intracellular Na + , K + and Ca 2+ levels were obtained in the case of Mg-orotate administration, while no significant changes in the intracellular Na + , K + and Ca 2+ levels were obtained by Mg supplementation as oxide, citrate or carbonate. The principal component analysis confirmed that the increase of intracellular Na + is accompanied by the increase of intracellular K + and vice versa. Also, high intracellular Ca 2+ levels are expected at low Mg 2+ doses. RezumatAdministrarea de Mg 2+ determină nu numai o creștere a conținutului de Mg 2+ , ci și modificări ale nivelurilor de Ca 2+ , K + și Na + în țesuturi. În această lucrare s-a studiat influența compușilor cu Mg 2+ asupra macro-elementelor (Ca 2+ , K + , Na + ) în țesuturile (inimă, ficat, splină, rinichi și plămâni) de șoareci. Au fost administrate doze de 300, 200, 100, 50 și 25 mg de diferiți compuși de Mg (orotat, sulfat, oxid, clorură, carbonat, citrat) prin gavaj. Rezultatele indică o creștere a nivelurilor de Na + și K + , în timp ce nivelul de Ca 2+ scade odată cu creșterea nivelului de Mg 2+ . În toate organele, nivelul de macro-elemente scade în următoarea ordine: K + > Na + > Ca 2+ . Cele mai mari niveluri intracelulare de Na + , K + și Ca 2+ au fost obținute în cazul administrării de orotat de Mg, în timp ce, ca urmare a administrării de Mg 2+ sub formă de oxid, citrat sau carbonat, nu au fost observate schimbări semnificative în nivelul intracelular de Na + , K + și Ca 2+ . Analiza componentelor principale a confirmat creșterea K + intracelular odată cu creșterea Na + și vice-versa. De asemenea, concentrații ridicate de Ca 2+ intracelular apar la administrarea de doze mici de Mg 2+ .
Modern lifestyle, excessive chemicalization of agricultural products, excessive processing and refining of food, cause a decrease in daily intake of magnesium, cation with an extremely important role in prevention and treatment of many diseases. As a result, there arises the need for extra magnesium intake in the form of dietary supplements. In this study were evaluated the physical and chemical stability of magnesium-containing tablets, depending on the active compound and the excipients used. Magnesium tablets in the form of orotate, lactate, citrate, oxide and hydroxide were taken into study and physical and chemical stability were observed over the validity period, at 6 and at 12 months after expiry date. There were no changes in physical and chemical stability during the validity period of the studied tablets. At 6 months after the expiry date, were observed variations in chemical composition with decrease in magnesium concentration to 98% of the declared value, only in the case of tablets containing magnesium lactate. At 12 months, the magnesium concentration decreased in all analysed samples, with no statistically significant differences (p[0.05) between the types of magnesium compounds � 95% for the orotate, 93% for the lactate, 90% for the oxide and hydroxide, respectively 85% for citrate. The results of this study indicate the therapeutically safety for using these tablets 6 months after the expiry date.
This research establishes the relationship between the influence of the stability of 6 magnesium compounds on their cellular uptake and focuses on the comparation between them, finding out which is the magnesium compound with the best bioavailability, depending on the stability. Mg2+ was dosed from tissues taken from various mice organs after the administration of compounds containing it, during the shelf life of the compounds, respectively at 6/12 months after their expiration. Different quantities of substances were also used � 25/50/100/200/300 mg/day/mouse, in groups of 2 mice for each dose. The samples were administered by gavage, following in parallel the possible side effects that may occur. During the shelf life of the compounds and at 6 months after expiration, in all organs, the lowest value was obtained for magnesium oxide and the highest value was detected for magnesium citrate. At 12 months after expiration, in all organs, the lowest/highest value was obtained in the case of oxide/orotate, respectively. It was found that the highest concentration of magnesium is stored in the spleen and lowest in lungs. The data obtained demonstrated a good stability of the tested substances (indicated by maintaining the cellular uptake rate) even 6 months after the expiration date.
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