Reducing the cytotoxicity while improving the anti-cancer activity of silver nanoparticles through α-tocopherol succinate modification

Abstract

By releasing Ag + ions and generating reactive oxygen species (ROS), silver nanoparticles (Ag NPs) not only have good anti-tumor activity but also display cytotoxicity towards normal cells which limits their further application in the medical field. Up to now, there was still no appropriate method to reduce the cytotoxicity while improving the anti-cancer activity of Ag NPs. This paper focuses on counteracting the toxic side effect of the ROS from Ag NPs while simultaneously improving their anti-cancer effect. We used a-TOS to modify Ag NPs and investigated their bioactivity in vitro for the first time. The modified AgNPs with a high a-TOS concentration not only show much higher anti-tumor activity than Ag NPs alone but also promote the survival of normal cell lines slightly, while the modified Ag NPs with a low a-TOS concentration display a lower cytotoxicity against normal cell lines without affecting their anti-cancer activity when compared to Ag NPs alone. Therefore, this work presents a higher potential for cancer treatment than using Ag NPs alone.

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

“…In cancer cells inhibition, the ROS generation in the inside of the cancer cells due to the oxidative stress responses that stimulated by treated material is an important study ( Hu et al, 2015 ). The IC50 concentration of Ag NPs treated A549 cancer cells in our study was also proved that the cancer cells were produced the ROS in more amounts.…”

Preparation of triangular silver nanoplates by silver seeds capped with citrate-CTA+

“…Silver nanoparticles (AgNPs), a versatile nanomaterial, have attracted a great deal of attention largely owing to their remarkable physical, chemical, biological properties, e.g., photo-thermal effect, 1 electronic properties, 2 catalytic properties, [3][4][5][6] anti-cancer and anti-bacterial properties, 3,[7][8][9][10][11][12][13][14][15] as well as antifungal effects. 16 In recent years, the chemical synthesis of AgNPs mostly focused on the uniformity of morphologies and sizes because these two parameters can affect intrinsic properties of AgNPs, [17][18][19] such as localized surface plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), metalenhanced uorescence, and catalytic activity.…”

Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

“…Due to the potential cytotoxicity of Ag NPs (Mijnendonckx et al, 2013;Hu et al, 2015;Tian et al, 2020), Magnetic thermotherapy produces local heat for sterilization Raval et al, 2017;Moniri et al, 2018a people began to pay attention to other noble metal nanoparticles, such as gold nanoparticles (Au NPs), copper nanoparticles (Cu NPs) and so on. Au NPs have many unique properties, like low toxicity, photothermal effect, large specific surface area, multifunctional surface modification and multivalent effect, etc (Xianyu et al, 2014;Connor and Broome, 2018).…”