Reduced toxicity with equivalent outcomes using three-dimensional volumetric (3DV) image–based versus nonvolumetric point–based (NV) brachytherapy in a cervical cancer population

Thomas, Kris G.; Maquilan, Genevieve; Stojadinović, Strahinja; Medin, Paul M.; Folkert, Michael R.; Albuquerque, Kevin

doi:10.1016/j.brachy.2017.05.001

Cited by 12 publications

(18 citation statements)

References 26 publications

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“…The shortest follow-up period was about 24 months in two studies (8,20), while the others reported follow-up time over 44 months. The aim of treatment was mostly definitive, and rate of concurrent chemotherapy varied.…”

Section: Study Characteristicsmentioning

confidence: 98%

“…Table 1 Study and clinicopathological characteristics of studies included in meta-analysis. There was one study that provided local recurrence-free survival as defined by relapse occurring in primary cervical lesion instead of LRRFS, which also included relapse occurring in nodal area (8), and another study which did not provide clear definition of local control (20). However, both were also included for LRRFS analysis with flexibility.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two trials did not provide drop-out information, so that they had moderate risks of attrition bias (8,22). Regarding prognostic factor measurement, one study had a moderate risk of bias as it did not report continuous variables for age, follow-up time, or information on major clinicopathological factors such as pathology and EBRT dose (20). For outcome measurement, one study had a moderate risk of bias, because of an unclear definition of local control (20).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Regarding prognostic factor measurement, one study had a moderate risk of bias as it did not report continuous variables for age, follow-up time, or information on major clinicopathological factors such as pathology and EBRT dose (20). For outcome measurement, one study had a moderate risk of bias, because of an unclear definition of local control (20). Regarding confounding bias, two studies had a moderate risk as no multivariate analysis was performed (20,21).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…For outcome measurement, one study had a moderate risk of bias, because of an unclear definition of local control (20). Regarding confounding bias, two studies had a moderate risk as no multivariate analysis was performed (20,21).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Impact of brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: A Systematic Review and Meta-analysis

Kim¹,

Kang²,

Kim³

2020

Preprint

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Background: To perform a systematic review and meta-analysis of the impact of brachytherapy (BT) technique (two-dimensional [2D] or three-dimensional image-guided [3D]) on outcomes of cervical cancer patients.Methods: PubMed and Embase databases were searched up to April 16, 2019, for studies which evaluated the effect of 3D-BT compared to 2D-BT in cervical cancer, and endpoints included cumulative incidence of severe toxicity, locoregional recurrence-free survival (LRRFS), progression-free survival (PFS), and overall survival (OS). Hazard ratios (HRs) were pooled in the meta-analysis using the random-effects model.Results: Six studies of 8 cohorts were included in the quantitative synthesis. The pooled hazard ratio (HR) regarding toxicity was evaluated in 5 cohorts in 3 studies, and the HR of 3D-BT compared to 2D-BT was 0.54 (95% confidence interval [CI], 0.37-0.77). All 6 studies were included for the synthesis for LRRFS, and the pooled HR favors 3D-BT (0.61 [95% CI, 0.40-0.93]). For PFS, 3 studies were included for analysis and 3D-BT was superior to 2D-BT (HR = 0.75 [95% CI, 0.0.59–0.96]). Five studies were included for the pooled HR regarding OS, and pooled HR of 3D-BT compared to 2D-BT was 0.65 (95% CI, 0.40–1.06).Conclusions: 3D-BT might reduce severe toxicity and improve LRRFS, and PFS in patients with cervical cancer. 3D-BT should be considered for standard management of cervical cancer, and efforts for adopting this procedure in Korea should be pursued.

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Section: Study Characteristicsmentioning

confidence: 98%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Impact of brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: A Systematic Review and Meta-analysis

Kim¹,

Kang²,

Kim³

2020

Preprint

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Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a systematic review and meta-analysis

2020

View full text Add to dashboard Cite

Background: To perform a systematic review and meta-analysis of the impact of brachytherapy (BT) technique (two-dimensional [2D] or three-dimensional image-guided [3D]) on outcomes of cervical cancer patients.Methods: PubMed and Embase databases were searched up to April 16, 2019, for studies which evaluated the effect of 3D-BT compared to 2D-BT in cervical cancer, and endpoints included cumulative incidence of severe toxicity, locoregional recurrence-free survival (LRRFS), progression-free survival (PFS), and overall survival (OS). Hazard ratios (HRs) were pooled in the meta-analysis using the random-effects model.Results: Six studies of 8 cohorts were included in the quantitative synthesis. The pooled hazard ratio (HR) regarding toxicity was evaluated in 5 cohorts in 3 studies, and the HR of 3D-BT compared to 2D-BT was 0.54 (95% con dence interval [CI], 0.37-0.77). All 6 studies were included for the synthesis for LRRFS, and the pooled HR favors 3D-BT (0.61 [95% CI, 0.40-0.93]). For PFS, 3 studies were included for analysis and 3D-BT was superior to 2D-BT (HR = 0.75 [95% CI, 0.0.59-0.96]). Five studies were included for the pooled HR regarding OS, and pooled HR of 3D-BT compared to 2D-BT was 0.65 (95% CI, 0.40-1.06).Conclusions: 3D-BT might reduce severe toxicity and improve LRRFS, and PFS in patients with cervical cancer. 3D-BT should be considered for standard management of cervical cancer, and efforts for adopting this procedure in Korea should be pursued.

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Novel use of ViewRay MRI guidance for high-dose-rate brachytherapy in the treatment of cervical cancer

Huang

Miller

et al. 2018

Brachytherapy

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Reduced toxicity with equivalent outcomes using three-dimensional volumetric (3DV) image–based versus nonvolumetric point–based (NV) brachytherapy in a cervical cancer population

Cited by 12 publications

References 26 publications

Impact of brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: A Systematic Review and Meta-analysis

Impact of brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: A Systematic Review and Meta-analysis

Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a systematic review and meta-analysis

Novel use of ViewRay MRI guidance for high-dose-rate brachytherapy in the treatment of cervical cancer

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