Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects

Abdulah, Rizky; Noerjasin, Herlambang; Septiani, Leri; Mutakin,; Defi, Irma Ruslina; Suradji, Eka W.; Puspitasari, Irma Melyani; Barliana, Melisa Intan; Yamazaki, Chiho; Nakazawa, Minato; Koyama, Hiroshi

doi:10.1007/s12011-013-9701-0

Cited by 22 publications

(9 citation statements)

References 38 publications

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“…Periconceptional deficiencies of vitamin E, 21 thiamine, 82 and selenium 83 among others have been variably associated with spontaneous or recurrent pregnancy loss. Folate supplementation in an observational USA study of almost 16,000 women has been linked to a 20% lower risk of miscarriage (adjusted risk ratio [RR]: 0.80, 95% CI 0.71–0.90).…”

Section: Antenatal Effects Across the Lifespanmentioning

confidence: 99%

Micronutrient deficiencies in pregnancy worldwide: health effects and prevention

et al. 2016

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Micronutrients, vitamins and minerals accessible from the diet, are essential for biologic activity. Micronutrient status varies widely throughout pregnancy and across populations. Women in low-income countries often enter pregnancy malnourished, and the demands of gestation can exacerbate micronutrient deficiencies with health consequences to the fetus. Examples of efficacious single micronutrient interventions include folic acid to prevent neural tube defects, iodine to prevent cretinism, zinc to reduce of preterm birth, and iron to reduce the risk of low birth weight. Folic acid and vitamin D might also increase birth weight. While extensive mechanism and association research links antenatal multiple micronutrients to plausible materno-fetal health advantages, hypothesized benefits have often been absent, minimal or unexpected in trials. These findings suggest a role for population context in determining health responses and extensive gaps in knowledge. Multiple micronutrient supplements reduce risks of being born low birth weight, small for gestational age or stillborn in undernourished settings, and justify micronutrient interventions with antenatal care. Measurable health effects of gestational micronutrient exposure may persist into childhood but few data exists on potential long-term benefits. In this Review, we discuss micronutrient intake recommendations, risks and consequences of deficiencies, and the effects of interventions with a particular emphasis on offspring.

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Section: Antenatal Effects Across the Lifespanmentioning

confidence: 99%

Micronutrient deficiencies in pregnancy worldwide: health effects and prevention

et al. 2016

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“…The selenium concentration was calculated based on the fluorometric measurements at an excitation wave length of 378 nm and an emission wave length of 525 nm to determine the concentration of piazoselenol, which is produced by the reaction of selenite with 2,3-diamino naphtalene. 7 The validity of the selenium analysis was confirmed by the measurement of a reference material (bovine liver, SRM 1577b, National Institute of Standards and Technology, USA).…”

Section: Methodsmentioning

confidence: 93%

“…The glutathione peroxidase activities were spectrophotometrically measured based on the decreasing rate of NADPH used in the reduction of glutathione, which was generated from oxidized glutathione through a reaction catalyzed by glutathione reductase. 7 Hydrogen peroxide and reduced glutathione were used as substrates at 37 °C in the presence of NADPH and glutathione reductase. The rate of NADPH oxidation at 340 nm was used as an index of hydrogen peroxide reduction.…”

Section: Methodsmentioning

confidence: 99%

“…6 It was also suggested that low serum selenium levels are linked to miscarriage; hence, selenium seems to play an important role in pregnancy maintenance. 7 GPx activities and low serum concentrations of selenium have been linked to increased risk of many types of cancer including prostate, lung, colorectal, and bladder. [8][9][10] However, the role of selenium in preventing carcinogenesis of the cervical is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review

Septiani

Hidayat

Mutakin

et al. 2016

IJIHS

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Objective: To analyze the role of selenium and glutathione peroxidase (GPx) in cervical cancer. Methods: Serum selenium concentrations and GPx activities of 19 women with cervical cancer along with their healthy counterparts (control group) were obtained. Selenium concentration were measured fluorometrically and GPx activities were measured spectrophotometrically based on the quantity of NADPH used in the reduction of glutathione. Results: The mean of serum selenium concentrations in cervical cancer group was significantly lower than that in the control group, 67.24±15 ng/mL and 77.05±12 ng/mL (p=0.03), respectively. The mean GPx activity in the cervical cancer group was also significantly lower than that in the control group, 128.18±38 ∆mmol NADPH/min/L and 148.9±23 ∆mmol NADPH/min/L (p=0.04), respectively. Multivariate analysis in the cervical cancer patients showed that the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) staging score (early vs. advanced) was inversely correlated with serum selenium concentration (p=0.027). Conclusions: Serum selenium concentration and GPx activity was significantly lower in the cervical cancer patients. Our results demonstrate that selenium and GPx activity may have an important role in the carcinogenesis of cervical cancer.

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“…Glutathione peroxidase (GPx) is a Se-dependent enzyme that has an antioxidant activity. Since there is an increase in free radicals and reactive oxygen species in miscarrying, Se may have an important role in abortion (20). Also Cu acts as a cofactor in superoxide dismutase.…”

Section: Discussionmentioning

confidence: 99%

Copper and selenium levels in women with second-trimester induced abortion in Mazandaran, 2009: A case control study

et al. 2015

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Abortion is the termination of a pregnancy by the removal or expulsion of a fetus or embryo from the uterus, resulting in or caused by its death. Missed abortion is the most common dangerous condition in pregnancy. An abortion can occur due to maternal complications, chronic disease, endocrine disorders, abortificient drugs, radiation, heavy metals and toxins. The study population consisted of 43 aborted patients and 43 normal pregnant females, referred to Imam Khomeini hospital. 10 mL blood was taken and centrifuged to isolate the patients' serum. Then, the samples were analyzed to determine the copper and selenium levels, using atomic absorption spectrometry. All data were statistically analyzed by T-test and Mann-Whitney methods. As a result, we found a significant decrease in serum copper level in cases compared with controls. Also the results showed an insignificant decrease in serum selenium levels in the patients compared to the healthy women. According to the results, deficiency of the essential heavy metals may be a probable reason for missed abortion occurrence. These deficiencies can be related to malnutrition, decreased consumption of essential metals and supplementary compounds in pregnancy, lack of regular laboratory monitoring. Thus, consuming supplements in Iranian pregnant women can be helpful in completing a successful pregnancy.

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Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects

Cited by 22 publications

References 38 publications

Micronutrient deficiencies in pregnancy worldwide: health effects and prevention

Micronutrient deficiencies in pregnancy worldwide: health effects and prevention

Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review

Copper and selenium levels in women with second-trimester induced abortion in Mazandaran, 2009: A case control study

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