Reduced protective effect of Plasmodium berghei immunization by concurrent Schistosoma mansoni infection

Laranjeiras, Ramon F; Brant, Luísa Campos Caldeira; Lima, A. Oliveira; Coelho, Paulo Marcos Zech; Braga, Érika Martins

doi:10.1590/s0074-02762008000700008

Cited by 15 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies demonstrated that children infected with S. mansoni are more likely to harbor P. falciparum parasites than children who do not have schistosomiasis (27). Our study, along with others (10,13,14,20,24,27), suggests that S. mansoni can decrease host immune responses to malaria parasites and/or the ability to clear infections following antimalarial treatment.…”

Section: Immune Responses During Coinfectionssupporting

confidence: 69%

“…A Plasmodium berghei-S. mansoni-coinfected mouse model displayed delayed clearance of parasitemia after malaria chemotherapy (14). Similarly, in a murine immunization model, concomitant infection with P. berghei and S. mansoni demonstrated increased mortality associated with malaria (13). However, these findings are limited, as the malaria species that infect mice do not adequately reflect the biology and pathogenesis of the species, particularly P. falciparum, that cause human malaria infections (8).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Schistosoma mansoni Infection Impairs Antimalaria Treatment and Immune Responses of Rhesus Macaques Infected with Mosquito-Borne Plasmodium coatneyi

et al. 2012

View full text Add to dashboard Cite

Malaria and schistosomiasis are the world's two most important parasitic infections in terms of distribution, morbidity, and mortality. In areas where Plasmodium and Schistosoma species are both endemic, coinfections are commonplace. Mouse models demonstrate that schistosomiasis worsens a malaria infection; however, just as mice and humans differ greatly, the murine-infecting Plasmodium species differ as much from those that infect humans. Research into human coinfections (Schistosoma haematobium-Plasmodium falciparum versus Schistosoma mansoni-P. falciparum) has produced conflicting results. The rhesus macaque model provides a helpful tool for understanding the role of S. mansoni on malaria parasitemia and antimalarial immune responses using Plasmodium coatneyi, a malaria species that closely resembles P. falciparum infection in humans. Eight rhesus macaques were exposed to S. mansoni cercariae. Eight weeks later, these animals plus 8 additional macaques were exposed to malaria either through bites of infected mosquitos or intravenous inoculation. When malaria infection was initiated from mosquito bites, coinfected animals displayed increased malaria parasitemia, decreased hematocrit levels, and suppressed malaria-specific antibody responses compared to those of malaria infection alone. However, macaques infected by intravenous inoculation with erythrocytic-stage parasites did not display these same differences in parasitemia, hematocrit, or antibody responses between the two groups. Use of the macaque model provides information that begins to unravel differences in pathological and immunological outcomes observed between humans with P. falciparum that are coinfected with S. mansoni or S. haematobium. Our results suggest that migration of malaria parasites through livers harboring schistosome eggs may alter host immune responses and infection outcomes.

show abstract

Section: Immune Responses During Coinfectionssupporting

confidence: 69%

mentioning

confidence: 99%

Schistosoma mansoni Infection Impairs Antimalaria Treatment and Immune Responses of Rhesus Macaques Infected with Mosquito-Borne Plasmodium coatneyi

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Although most studies were conducted on animal models, they reported that S. mansoni co-infection contributes to severe malaria presentation. They revealed that S. mansoni co-infection resulted in high Plasmodium parasitemia and increased susceptibility of infected mouse models to mortality [ 11 – 14 ]. In contrast, others illustrated that S. mansoni co-infection contributed to low Plasmodium parasitemia and inhibited cerebral malaria [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical correlates of Schistosoma mansoni co-infection among malaria infected patients, Northwest Ethiopia

et al. 2015

View full text Add to dashboard Cite

BackgroundIn Ethiopia, where malaria and schistosomiasis are co-endemic, co-infections are expected to be high. However, data about the prevalence of malaria-schistosomiasis co-infection and their clinical correlation is lacking. Therefore, the aim of this study was to assess prevalence of Schistosoma mansoni co-infection and associated clinical correlates in malaria patients.MethodsA cross-sectional study was conducted in 2013 at Chwahit Health Center, in northwest Ethiopia. Blood film positive malaria patients (N = 205) were recruited for the study. Clinical, parasitological, hematological, and biochemical parameters were assessed from every study participant. Stool samples were also collected and processed with Kato-Katz technique to diagnose and classify intensity of Schistosoma mansoni.ResultsThe prevalence of Schistosoma mansoni and malaria co-infection was 19.5 %. The age group of 16–20 years old was significantly associated with co-infection. Co-infected patients with a moderate-heavy egg burden of Schistosoma mansoni had significantly high mean Plasmodium parasitemia. On the other hand, age group of 6–10 years old and moderate-heavy Schistosoma mansoni co-infection were significantly associated with severe malaria.ConclusionsPrevalence of malaria and Schistosoma mansoni co-infection in the study area was considerably high. Severity of malaria and parasitemia of Plasmodium were associated with certain age groups and intensity of concurrent Schistosoma mansoni. Further study is needed to explore the underlying mechanisms of interaction between malaria and Schistosoma mansoni.

show abstract

“…Similar effects of H. polygyrus have been reported for a DNA malaria vaccine, but not for live, irradiated sporozoites, 48 or for live BCG, 49 indicating that the impact of a particular helminth differs by vaccine type: protein, DNA or live attenuated organisms. Mice infected with Schistosoma species (which cause systemic infections) show impaired induction of protective immunity both to malaria 50 and to TB challenge (following BCG), 51 indicating that different helminth infections have different effects. Schistosoma infections also resulted in impaired antibody responses to toxoid and protein vaccines—but a study on hepatitis B immunisation showed a gradual recovery of the response when the infection was treated after immunisation.…”

Section: Worms and Vaccinesmentioning

confidence: 99%

A life without worms

Sanya

Nkurunungi

Andia-Biraro

et al. 2017

Transactions of the Royal Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Worms have co-evolved with humans over millions of years. To survive, they manipulate host systems by modulating immune responses so that they cause (in the majority of hosts) relatively subtle harm. Anthelminthic treatment has been promoted as a measure for averting worm specific pathology and to mitigate subtle morbidities which may include effects on anaemia, growth, cognitive function and economic activity. With our changing environment marked by rapid population growth, urbanisation, better hygiene practices and anthelminthic treatment, there has been a decline in worm infections and other infectious diseases and a rise in non-communicable diseases such as allergy, diabetes and cardiovascular disease. This review reflects upon our age-old interaction with worms, and the broader ramifications of life without worms for vaccine responses and susceptibility to other infections, and for allergy-related and metabolic disease. We touch upon the controversy around the benefits of mass drug administration for the more-subtle morbidities that have been associated with worm infections and then focus our attention on broader, additional aspects of life without worms, which may be either beneficial or detrimental.

show abstract

Reduced protective effect of Plasmodium berghei immunization by concurrent Schistosoma mansoni infection

Cited by 15 publications

References 18 publications

Schistosoma mansoni Infection Impairs Antimalaria Treatment and Immune Responses of Rhesus Macaques Infected with Mosquito-Borne Plasmodium coatneyi

Schistosoma mansoni Infection Impairs Antimalaria Treatment and Immune Responses of Rhesus Macaques Infected with Mosquito-Borne Plasmodium coatneyi

Prevalence and clinical correlates of Schistosoma mansoni co-infection among malaria infected patients, Northwest Ethiopia

A life without worms

Contact Info

Product

Resources

About