2012
DOI: 10.1128/iai.00590-12
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Schistosoma mansoni Infection Impairs Antimalaria Treatment and Immune Responses of Rhesus Macaques Infected with Mosquito-Borne Plasmodium coatneyi

Abstract: Malaria and schistosomiasis are the world's two most important parasitic infections in terms of distribution, morbidity, and mortality. In areas where Plasmodium and Schistosoma species are both endemic, coinfections are commonplace. Mouse models demonstrate that schistosomiasis worsens a malaria infection; however, just as mice and humans differ greatly, the murine-infecting Plasmodium species differ as much from those that infect humans. Research into human coinfections (Schistosoma haematobium-Plasmodium fa… Show more

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Cited by 24 publications
(13 citation statements)
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“…Although some animal studies have shown that chronic schistosomiasis protects against severe malaria (5), others have reported that a concurrent schistosome infection enhances the severity of malaria (6)(7)(8)(9)(10). Many factors may account for these differences, including mouse strain, duration and intensity of the helminth infection, Plasmodium strain or species, inoculum size, or route of malaria infection (skin or blood stage) (11). An important limitation of murine studies is the difficulty of establishing chronic schistosome infections comparable to those observed in humans.…”
mentioning
confidence: 99%
“…Although some animal studies have shown that chronic schistosomiasis protects against severe malaria (5), others have reported that a concurrent schistosome infection enhances the severity of malaria (6)(7)(8)(9)(10). Many factors may account for these differences, including mouse strain, duration and intensity of the helminth infection, Plasmodium strain or species, inoculum size, or route of malaria infection (skin or blood stage) (11). An important limitation of murine studies is the difficulty of establishing chronic schistosome infections comparable to those observed in humans.…”
mentioning
confidence: 99%
“…Studies addressing the effect of coinfection on malarial anemia showed variable results with complex outcomes on anemia [21]. Similar outcomes were seen with studies dealing with the issue of treating coinfection or not [22].…”
Section: Treating Coinfecting Organismsmentioning
confidence: 54%
“…Macaques are also used to study a wide range of infections with human pathogens or their simian counterparts, as well as vaccines [60,61]. Thus, it is possible to model co-infections in macaques, such as SIV/Plasmodium [62][63][64][65] and Schistosoma/Plasmodium [66] and to study interference with vaccine-induced immune responses [67].…”
Section: Simian Plasmodium Species In Macaquesmentioning
confidence: 99%