2016
DOI: 10.1128/iai.00490-15
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Protective Effect of Chronic Schistosomiasis in Baboons Coinfected with Schistosoma mansoni and Plasmodium knowlesi

Abstract: c Malaria and schistosomiasis coinfections are common, and chronic schistosomiasis has been implicated in affecting the severity of acute malaria. However, whether it enhances or attenuates malaria has been controversial due the lack of appropriately controlled human studies and relevant animal models. To examine this interaction, we conducted a randomized controlled study using the baboon (Papio anubis) to analyze the effect of chronic schistosomiasis on severe malaria. Two groups of baboons (n ‫؍‬ 8 each) an… Show more

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Cited by 11 publications
(14 citation statements)
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References 68 publications
(75 reference statements)
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“…This study involved a total of ten Olive baboons (Papio anubis) which were housed at the Institute of Primate Research (IPR [www.primateresearch.org]), Karen, Nairobi, Kenya. This was according to institutional standards and guidelines for primate welfare and housing based on the International Guiding principles for Biomedical [30].…”
Section: Methodsmentioning
confidence: 99%
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“…This study involved a total of ten Olive baboons (Papio anubis) which were housed at the Institute of Primate Research (IPR [www.primateresearch.org]), Karen, Nairobi, Kenya. This was according to institutional standards and guidelines for primate welfare and housing based on the International Guiding principles for Biomedical [30].…”
Section: Methodsmentioning
confidence: 99%
“…Both grouped and individual cages were designed to allow natural light and dark cycles and they had ad libitum access to water. They were fed daily with monkey cubes (Unga Farm Care, Ltd, Nairobi, Kenya) and supplemented with fruits and vegetables [30].…”
Section: Methodsmentioning
confidence: 99%
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“…Most laboratory-based animal studies have shown an exacerbation of malaria parasitaemia in Schistosoma infected mice [ 10 13 ] whilst others have revealed a protective effect of Schistosoma infection against experimental cerebral malaria and associated mortality [ 14 17 ]. In experimental S .…”
Section: Introductionmentioning
confidence: 99%