Reduced Pathology following Infection with TransgenicLeishmania majorExpressing Murine CD40 Ligand

Field, Ann E.; Wagage, Sagie; Conrad, Sean M.; Mosser, David M.

doi:10.1128/iai.00160-07

Cited by 11 publications

(14 citation statements)

References 43 publications

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“…The same thing was reported by Rolph and Kaufmann (2001), Chen et al (2001) and Field et al (2007) which uses a combination of CD40 and vaccine of heat-killed Listeria mononcytogenes and Leishmania major. The development of vaccines based on cell-mediated immunity was also reported by Lawrence et al (2012) in a vaccination using HKSA.…”

Section: Vaccination Based On Cell-mediated Immunitysupporting

confidence: 68%

Staphylococcus aureus Vaccine Candidate from MRSA Isolates: The Prospect of a Multivalent Vaccine

Sandi¹,

Wanahari²,

MacPhillamy³

et al. 2015

American Journal of Infectious Diseases

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Staphylococcus aureus (S. aureus) is a major cause various infections in humans and animals throughout the world. The increasing incidence of S. aureus infection, particularly methicillin-resistant Staphylococcus aureus (MRSA) is complicated by the antibiotic-resistance phenomenon. Thus, it requires new strategies to prevent wider scale of its incidence occurring. Preventative methods against infectious diseases through vaccination can prevent, control and reduce the severity of the disease process. Various methods have been used in the development of vaccines to prevent S. aureus infections, but no satisfactory results have been obtained. Recent studies suggests that multivalent vaccines based on cell-mediated immunity is expected to provide better protection against infection. The purpose of this article is to summarize the challenges of S. aureus infection and the current status of its potential solution with the development of a multivalent vaccine and to explain the latest approaches recommended to obtain successful development of S. aureus vaccine by inducing T-cells CD8+, CD4+ and Th17. Seven MRSA Indonesian origin isolates from humans and dairy-cattle were used as candidate vaccines as genotypic characterization had previously been performed (coa, eta, etb, hla, hlb, cap5, cap8, fnbA, fnbB and mecA). Vaccination can be performed with live-attenuated or killed-vaccine and could be combined with an injection of αCD40 monoclonal-antibodies (mAbs) with the aim to induce cellular-based active immunity (T CD8+, CD4+ and Th17). These isolates are expected to be safe vaccine candidates with immunogenic-protective properties based on genetic and antigenic variation to prevent and control staphylococcal infections in humans and animals.

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Section: Vaccination Based On Cell-mediated Immunitysupporting

confidence: 68%

Staphylococcus aureus Vaccine Candidate from MRSA Isolates: The Prospect of a Multivalent Vaccine

Sandi¹,

Wanahari²,

MacPhillamy³

et al. 2015

American Journal of Infectious Diseases

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“…Another approach to stimulate CD40 signaling during immunization has been to utilize transgenic parasites that express CD154. Compared to wild-type parasites, infection with L. major promastigotes that express the extracellular domain of CD154 caused mild disease in susceptible BALB/c mice and afforded resistance against challenge infection to C57BL/6 mice [121]. …”

Section: Leishmaniamentioning

confidence: 99%

CD40 and the immune response to parasitic infections

Subauste

2009

Seminars in Immunology

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The interaction between CD40 and CD154 regulates many aspects of cellular and humoral immunity. The CD40 -CD154 pathway is important for resistance against a variety of parasites. Studies done with these pathogens have provided important insight into the various mechanisms by which this pathway enhances host protection, mechanisms by which pathogens subvert CD40 signaling, conditions in which the CD40 -CD154 pathway promotes disease and on modulation of this pathway for immunotherapy.

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“…Susceptibility to L. major infection has been linked to a deficiency in the engagement between CD40 and CD40L. 8,[38][39][40][41][42][43][44] Furthermore, B7-mediated costimulation is required for the development of the early immune response following infection of either resistant or susceptible mice. 45 Therefore, activation and maturation of APCs with expression of MHC molecules, CD40 and CD80 on the surface of APCs is fundamental to the process of costimulation of T cells for an efficient response to L. major infection.…”

Section: Discussionmentioning

confidence: 99%

Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice

Amaral¹,

Gomes-Santos²,

Paula-Silva³

et al. 2010

Immunology

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Summary The immature immune system requires constant stimulation by foreign antigens during the early stages of life to develop properly and to create efficient immune responses against later infections. We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)‐based diet during the development of the immune system subsequently resulted in inefficient control of Leishmania major infection in adult C57BL/6 mice. Compared with mice fed a control protein‐containing diet, adult aa‐fed mice showed a decreased interferon (IFN)‐γ response to parasite antigens and insufficient production of nitric oxide (NO), which is crucial to parasite death. However, no deviation towards Th2‐specific immunity to L. major was observed. Phenotypic analysis of antigen‐presenting cells (APCs) from aa‐fed mice revealed deficient levels of the costimulatory molecules CD40 and CD80, and low levels of interleukin (IL)‐12 produced by peritoneal macrophages, revealing an early stage of maturation of these cells. APCs isolated from aa‐fed mice were unable to stimulate a Th1 response in vitro. Both phenotypic features of T cells from aa‐fed mice and their ability to produce a Th1 response in the presence of mature APCs were unaffected when compared with T cells from control mice. The results presented here support the notion that regulation of Th1 immunity to infection includes environmental factors such as dietary proteins, which provide a natural source of stimulation that contributes to the process of maturation of APCs.

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Reduced Pathology following Infection with TransgenicLeishmania majorExpressing Murine CD40 Ligand

Cited by 11 publications

References 43 publications

<i>Staphylococcus aureus</i> Vaccine Candidate from MRSA Isolates: The Prospect of a Multivalent Vaccine

<i>Staphylococcus aureus</i> Vaccine Candidate from MRSA Isolates: The Prospect of a Multivalent Vaccine

CD40 and the immune response to parasitic infections

Antigenic dietary protein guides maturation of the host immune system promoting resistance to Leishmania major infection in C57BL/6 mice

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