Reduced olfactory bulb volume and diminished olfactory function in total laryngectomy patients: A prospective longitudinal study

Veyseller, Bayram; Özüçer, Berke; Aksoy, Fadlullah; Yıldırım, Yavuz Selim; Gürbüz, Defne; Balikci, Hasan Huseyin; Özturan, Orhan

doi:10.2500/ajra.2012.26.3768

Cited by 23 publications

(29 citation statements)

References 15 publications

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“…This supports the findings discovered in experimental animals, in which decreased inputs from the olfactory epithelium resulted in reduction of OB volume. 19,20 Similarly, Veyseller et al 13 have reported decreased OB volume in total laryngectomy patients, a finding that the authors attributed to lack of nasopulmonary airflow, inability to sniff normally, complex neural interruptions caused by surgical denervation of the larynx.…”

Section: Discussionmentioning

confidence: 95%

Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study

Herzallah

Askar

Amer

et al. 2013

Otolaryngol.--head neck surg.

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Section: Discussionmentioning

confidence: 95%

Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study

Herzallah

Askar

Amer

et al. 2013

Otolaryngol.--head neck surg.

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“…Veyseller et al [62] Ward et al: Olfaction following total laryngectomy Although these tests yield comparable net results, each remains diagnostically exclusive.…”

Section: Mucociliary Functionmentioning

confidence: 97%

“…Further to these, newer technologies that utilize medical imaging techniques to examine olfactory function are being developed. These include such techniques as rhinomanometry to measure nasal airflow, pressure and resistance in the nostrils, [55] and magnetic resonance imaging to determine degree of olfactory bulb loss [62] [ Table 2]. Although the latter are valid objective assessments, these techniques are generally not viable for clinical use due to time, costs, and need for trained personnel.…”

Section: Mucociliary Functionmentioning

confidence: 99%

Olfaction following total laryngectomy

2012

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Total laryngectomy (TL) results in the complete disconnection of the upper and lower respiratory tract, ceasing orthonasal airflow. Hence, olfaction and olfactory acuity are negatively impacted. Prior to the late 1990s, impaired olfaction was simply accepted as a negative consequence of TL surgery. However, a growing body of research conducted within this past decade has demonstrated that rehabilitation is possible with a simple and effective behavioral technique. The current review outlines the literature supporting the negative impact of altered olfaction on quality of life, details of known best practice methods for olfactory assessment both for research and clinical use, and outlines the evidence for interventions known to improve olfactory performance in the TL population. Intervention for olfactory impairment should be part of a holistic, evidence-based rehabilitation process for patients post-laryngectomy. Optimized content for mobile and hand-held devicesHTML pages have been optimized of mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)

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“…A more recent study indicated a significant reduction in the volume of the olfactory bulb of total laryngectomized patients compared to the pre-surgery size, suggesting that the total removal of the larynx interrupts the nasal airflow and the olfactory input for the olfactory bulb, causing the reduction of the olfactory acuity and its volume 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the total laryngectomized patient has a decrease in the olfactory perception (hiposmia) or even a total absence of olfaction (anosmia) 8,9 .…”

Section: Conflict Of Interest: Non-existentmentioning

confidence: 99%

Acuidade olfatória e qualidade de vida após a laringectomia total

et al. 2015

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RESUMO: Objetivo: identificar a prevalência e os fatores associados às alterações do olfato e descrever a qualidade de vida após a laringectomia total. Métodos: estudo transversal para avaliar a acuidade olfatória e a qualidade de vida de laringectomizados totais no Instituto Nacional de Câncer por meio da aplicação do Teste de Identificação do Olfato da Universidade da Pensilvânia, do Questionário de Qualidade de Vida da Universidade de Washington e do Questionário sobre a Acuidade Olfatória Pré-Reabilitação do Olfato. Resultados: foram avaliados 48 laringectomizados totais, sendo 39 do sexo masculino e 9 do sexo feminino, com idade média de 62 anos e tempo médio de 5,6 anos desde a laringectomia total. No Teste de Identificação do Olfato a pontuação média foi de 17,9. De acordo com a classificação do olfato no teste, a maioria dos participantes apresentou algum grau de alteração, sendo que apenas 2 indivíduos tiveram o olfato considerado dentro da normalidade. No Questionário de Qualidade de vida da Universidade de Washington, o escore composto foi 80,47. Os domínios que apresentaram as médias de pontos mais baixas foram paladar, saliva e fala. No questionário sobre a acuidade olfatória pré-reabilitação do olfato, a maioria dos participantes consideraram seu olfato de ruim a razoável. 21 indivíduos relataram apresentar algum grau de dificuldade em suas atividades de vida diária em decorrência de alterações do olfato. Conclusão: os laringectomizados totais apresentaram alta prevalência de alterações do olfato, com comprometimentos relacionados às suas atividades de vida diária.

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Reduced olfactory bulb volume and diminished olfactory function in total laryngectomy patients: A prospective longitudinal study

Abstract: This longitudinal prospective study was the first to examine the cessation of olfactory stimulation in olfactory deficiency resulting from OB functional and structural changes.

Cited by 23 publications

References 15 publications

Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study

Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study

Olfaction following total laryngectomy

Acuidade olfatória e qualidade de vida após a laringectomia total

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