Abstract:The resistance among various opportunistic Fusarium species to different antifungal agents has emerged as a cause of public health problems worldwide. Considering the significance of multi-drug resistant (MDR), this paper emphasizes the problems associated with MDR and the need to understand its clinical significance to combat microbial infections. The search platform PubMed/MEDLINE and a review of 32 cases revealed a common multidrug-resistant profile exists, and clinically relevant members of Fusarium are in… Show more
“…Although fusariosis is associated with specific climatic conditions, environmental and clinical isolates have been reported to cause infections outside previously established borders 14 . This fungus has efficient mechanisms of dispersion, and its conidia reach considerable distances 9 . Moreover, genetic similarities between clinical isolates and environmental isolates of the same species may be related to infections in patients by Fusarium spp.…”
Section: Emergence Of Pathogenic Fusarium Speciesmentioning
confidence: 99%
“…Invasive infections can be widespread involving the skin, brain, bloodstream, lungs, eyes, and bones 14,17,18 . Patients with severe and prolonged neutropenia, especially those with hematological malignancies, are most susceptible to prevalent infections 9,18 .…”
Section: Clinical Aspects Of Fusariosismentioning
confidence: 99%
“…Keratitis is one of the most common infections caused by Fusarium spp. and primarily develops from trauma to the eye, contact lens wear, and use of corticosteroids 9,19,22 . Trauma is the key predisposing factor and occurs in 40-60 % of patients 19 .…”
Section: Clinical Aspects Of Fusariosismentioning
confidence: 99%
“…However, infections are difficult to treat because of the lack of consensus regarding treatment protocols for fusariosis in humans caused by multi-drug resistant isolates 2,8,9 . In addition, it is possible that environmental isolates from Fusarium spp.…”
Fusarium spp. has been associated with a broad spectrum of emerging infections collectively termed fusariosis. This review includes articles published between 2005 and 2018 that describe the characteristics, clinical management, incidence, and emergence of these fungal infections. Fusarium solani and F. oxysporum are globally distributed and represent the most common complexes. Few therapeutic options exist due to intrinsic resistance, especially for the treatment of invasive fusariosis. Therefore, the use of drug combinations could be an important alternative for systemic antifungal resistance. Increase in the number of case reports on invasive fusariosis between 2005 and 2018 is evidence of the emergence of this fungal infection.
“…Although fusariosis is associated with specific climatic conditions, environmental and clinical isolates have been reported to cause infections outside previously established borders 14 . This fungus has efficient mechanisms of dispersion, and its conidia reach considerable distances 9 . Moreover, genetic similarities between clinical isolates and environmental isolates of the same species may be related to infections in patients by Fusarium spp.…”
Section: Emergence Of Pathogenic Fusarium Speciesmentioning
confidence: 99%
“…Invasive infections can be widespread involving the skin, brain, bloodstream, lungs, eyes, and bones 14,17,18 . Patients with severe and prolonged neutropenia, especially those with hematological malignancies, are most susceptible to prevalent infections 9,18 .…”
Section: Clinical Aspects Of Fusariosismentioning
confidence: 99%
“…Keratitis is one of the most common infections caused by Fusarium spp. and primarily develops from trauma to the eye, contact lens wear, and use of corticosteroids 9,19,22 . Trauma is the key predisposing factor and occurs in 40-60 % of patients 19 .…”
Section: Clinical Aspects Of Fusariosismentioning
confidence: 99%
“…However, infections are difficult to treat because of the lack of consensus regarding treatment protocols for fusariosis in humans caused by multi-drug resistant isolates 2,8,9 . In addition, it is possible that environmental isolates from Fusarium spp.…”
Fusarium spp. has been associated with a broad spectrum of emerging infections collectively termed fusariosis. This review includes articles published between 2005 and 2018 that describe the characteristics, clinical management, incidence, and emergence of these fungal infections. Fusarium solani and F. oxysporum are globally distributed and represent the most common complexes. Few therapeutic options exist due to intrinsic resistance, especially for the treatment of invasive fusariosis. Therefore, the use of drug combinations could be an important alternative for systemic antifungal resistance. Increase in the number of case reports on invasive fusariosis between 2005 and 2018 is evidence of the emergence of this fungal infection.
“…This may be due in part to the poor susceptibility of Fusarium to most of the antifungal drugs currently available. Indeed, all Fusarium species are naturally resistant to echinocandins and flucytosine (11). Amphotericin B often offers the lowest MIC, but MIC 90 s of Ͼ2 mg/liter are commonly reported (8,12).…”
To evaluate the in vitro susceptibility of Fusarium to isavuconazole, 75 clinical isolates were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry and then tested with a broth microdilution method (EUCAST) and the gradient concentration strip (GCS) technique. The activity of isavuconazole overall was shown to be limited, with an MIC50 of >16 μg/ml, without significant differences between the species complexes. The categorical agreement between GCS and EUCAST was 97.4% to 100%, making the GCS as a valuable alternative.
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