Reduced Linear Hair Growth Rates of Vellus and of Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice

Gender differences in scalp hair growth rates are maintained but reduced in pattern hair loss compared to controls

“…Furthermore, increasing hair thickness was associated with an increase in LHGR, confirming previous findings in males (4,6) and human scalp grafts maintained on nude mice (4). While experimental data can be difficult to interpret (4,11), it has been proposed from human in vivo investigations that reduced hair diameter (thickness) has been the main causal factor for reduced hair growth rates, especially in Asian hair (12)(13)(14)(15). The report on reduced scalp hair growth rates in Japanese females with severe hair loss (14) did not clearly establish a relation with thickness.…”

“…This method allowed the verification of earlier findings on linear hair growth rates (LHGR) (4,5), provided parameters for the fundamental hair variables (7) (hair diameter, phase of growth and hair per cm 2 ) and herein, we present results for anagen hair follicle growth rates and hair diameter.…”

Chemotherapy-induced alopecia

“…One such experimental model, developed by van Neste et al [17], is the grafting of human scalp skin containing hair follicles onto the skin of nude mice. One such experimental model, developed by van Neste et al [17], is the grafting of human scalp skin containing hair follicles onto the skin of nude mice.…”

Protection Against Chemotherapy-Induced Alopecia

“…Although in vitro systems such as cell cultures and histocultures can be used to study the effects of chemotherapeutic agents on hair follicle, in vivo models are preferred due to the complexity of hair growth and cycling (37,41Y 44). An interesting experimental model is the grafting of human scalp skin containing hair follicles onto the skin of a mouse; the transplanted hairs are shed within a month, and the regrowth of new hair begins within several months after transplantation (45). This model has been used to study the biology of, and the effects of chemotherapy on, human hair follicles (46 Y 48).…”