Reduced expression of selective immune-related genes in silver catfish ( Rhamdia quelen ) monocytes exposed to atrazine

Kirsten, Karina; Canova, Raíssa; Soveral, Lucas de Figueiredo; Friedrich, Maria Tereza; Frandoloso, Rafael; Kreutz, Luiz Carlos

doi:10.1016/j.fsi.2017.03.006

Cited by 12 publications

(7 citation statements)

References 21 publications

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“…LYZ is also a key factor in innate immunity and involved in microbial sensing (Gao et al, 2017). ATZ-exposed tilapia showed reductions in immune response features that may be an immunosuppressive effect of ATZ (Kirsten et al, 2017). Augmentation of these immune features was observed in tilapia supplemented with βG due to its immunomodulating property (El-Murr et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have examined the effects of ATZ on various types of aquatic life, revealing acute and sub‐chronic injury. For example, ATZ seriously affects liver metabolism and immune responses in silver catfish (Kirsten et al, ; Kreutz, Barcellos, dos Santos, Pivato, & Zanatta, ), crayfish (Stara, Kouba, & Velisek, ) and common carp (Cui et al, ; Khalil, Reda, & Awad, ). Exposure to ATZ may also cause reproductive failure and reduce spermatogenesis in zebrafish (Bautista et al, ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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Three hundred Oreochromis niloticus were divided into five groups; the control fish (CNT) were fed a basal diet, beta glucan (βG) group was fed 0.5 g/kg−1 βG, atrazine (ATZ) group was exposed to 1/5 96‐hr LC50 (1.39 mg/L) ATZ, the (βG/ATZ) group was fed βG while being exposed to ATZ, and the (βG then ATZ) group was supplemented with βG for fifteen days before exposed to ATZ. ATZ exposure caused a decline in growth that was ameliorated by βG. ATZ reduced the levels of total and different types of leucocytes. Additionally, ATZ exposure caused reductions in total proteins, globulins, α 1‐globulin, α 2‐globulin, ɤ‐globulin, immunoglobulin M, lysozymes, superoxide dismutase, nitric oxide and catalase but increases in hepatic transaminases and malondialdehyde without any variations in albumin and β‐globulin. Exposure to ATZ also resulted in a rise in the mRNA level of IL‐8. In contrast, expression of IgM, SOD and CAT were decreased in the tilapias exposed to ATZ. Exposure to ATZ increases the susceptibility response to Aeromonas sobria challenge, as indicated by an increase in cumulative mortality post‐challenge. Supplementation with βG fifteen days before (βG then ATZ group), counteracted the adverse effects of ATZ on the immune, biochemical and antioxidants values, though only slight alleviation was observed with simultaneous treatment (βG/ATZ group). Our results established that ATZ has adverse impacts on immune responses, antioxidant equilibrium and its related genes. While, supplementation with βG before exposure to ATZ may be valuable for counteracting the possible damage caused by ATZ water pollution than its simultaneous treatment with ATZ.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

2020

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“…Immune suppressed fish might also have difficulties in tuning risk assessment of the environment during their exploratory activity in search for food and, as a consequence, become more susceptible to predators 28 . Aquatic contaminants like agrichemicals and drugs are known to alter the expression of specific cytokine genes 29 – 32 which, in addition to increasing susceptibility to infections, might cause behavioral changes, letting the fish more vulnerable to predation. In this scenario, immune dysfunctions when associated with behavioral changes would have a greater ecological impact and could contribute to reduce fish population in the wilderness.…”

Section: Discussionmentioning

confidence: 99%

First description of behavior and immune system relationship in fish

Kirsten

Fior

Kreutz

et al. 2018

Sci Rep

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Considering the intriguing relationship between immune system and behavior recently described in mammals, and the lack of information of this relationship in fish, here we describe for the first time the interaction between the immune system and social and exploratory behavior in zebrafish. Fish high responders to novelty (HRN) presented a proinflammatory profile, with increased IL-1β and reduced IL-10 expression compared to fish low responders to novelty (LRN). Likewise, fish less responsive to social stimuli have a reduced expression of INF-γ. We show that fish with different behavior patterns have differences in the immune response. Our findings indicate that the interplay between immune system and behavior in zebrafish is similar to that found in mammalian models and that zebrafish should be considered as a potential model organism to study the relationship between immune system and behavior.

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“…In the course of the analysis, two papers overlooked during the development of the original WoE assessment were identified and analyzed. In the end, the papers included in the QWoE update are: (Chang et al 2005;Hecker et al 2005;Svartz et al 2012;Ghodageri and Katti 2013;Olker 2014;Shenoy 2014;Baxter et al 2015;Chen et al 2015;Sai et al 2015Sai et al , 2018Syngenta 2015Syngenta , 2017aSyngenta , 2017bVan Der Kraak et al 2015;Wirbisky and Freeman 2015;dos Santos Mendonc¸a et al 2016;Ehrsam et al 2016;Gustafson et al 2016;Khan et al 2016aKhan et al , 2016bKhan et al , 2016cLiu et al 2016;Richter et al 2016;Russart and Rhen 2016;Tulaby Dezfuly and Mohammadian 2016;Wirbisky et al 2016aWirbisky et al , 2016bWirbisky et al , 2016cD'Angelo and Freeman 2017;Du Gas et al 2017;Hoskins et al 2017;Jones et al 2017;Khalil et al 2017;Kirsten et al 2017;McMahon et al 2017;Persch et al 2017;Scott et al 2017;Shukla et al 2017;Snyder et al 2017;Wang et al 2017;…”

Section: Methodsmentioning

confidence: 99%

Effects of atrazine on fish, amphibians, and reptiles: update of the analysis based on quantitative weight of evidence

Hanson

Solomon

Kraak

et al. 2019

Critical Reviews in Toxicology

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Quantitative weight of evidence (QWoE) provides a framework and process for evaluating different toxicological studies based on quality and relevance of the results. This framework allows for data from these studies to be combined in separate lines of evidence to address causality, and relevance to environmental risks. In 2014, such a QWoE that examined the body of available company reports and peer reviewed literature regarding the effects of the herbicide atrazine on fish, amphibians, and reptiles was published. Since that time, new studies have been conducted and/or published. One of the advantages of the QWoE framework is that additional information can be added as it becomes available. Thus, these new studies were evaluated in the same manner as previously and the new data incorporated into the existing QWoE. As before, the new updated QWoE was based on the same process of objective scoring of individual studies with respect to the quality of the methods and the relevance of individual responses to the apical endpoints of survival, growth, development, and reproduction. These new data did not identify new responses or indicate any relevant effects of atrazine. The new updated QWoE analysis concluded that atrazine does not adversely affect fish, amphibians, and reptiles, at environmentally relevant concentrations (<100 mg atrazine/L), which is consistent with the previous conclusions. These new studies and data are discussed in this paper and the accompanying supplement information provides detailed and transparent information to support these conclusions.

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Reduced expression of selective immune-related genes in silver catfish ( Rhamdia quelen ) monocytes exposed to atrazine

Cited by 12 publications

References 21 publications

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

Alleviating effects of β‐glucan inOreochromis niloticuson growth performance, immune reactions, antioxidant, transcriptomics disorders and resistance toAeromonas sobriacaused by atrazine

First description of behavior and immune system relationship in fish

Effects of atrazine on fish, amphibians, and reptiles: update of the analysis based on quantitative weight of evidence

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