Reduced expression of mannose‐specific receptors on murine peripheral blood polymorphonuclear leukocytes following prolonged anaesthesia with different inhalation agents

Abstract

Inhalation anaesthetic agents are known to depress phagocytic functions such as mobilization, attachment, chemotactic motility, engulfment and intracellular killing. Mannose-specific sugar receptors on the surface of leukocytes are involved in a series of phagocytosis-related activities. To investigate the effect of anaesthesia on the expression of this type of sugar receptor, mice were anaesthetized with halothane, enflurane and isoflurane. The presence of mannose-binding receptors on peripheral blood polymorphonuclear leukocytes was examined glycocytochemically using the biotinylated neoglycoprotein mannosylated bovine serum albumin. Prolonged administration of inhalation anaesthetic agents, especially halothane, markedly depressed expression of mannose-specific receptors. This reduction may possibly contribute to postoperative immunodepression, resulting from the impaired cellular interaction which is involved in the phagocytic function of granulocytes.

Effects of four anaesthetics on the innate immune response of gilthead seabream ( L.)

“…Anaesthesia may have immunodepressive e#ects in mammals [6][7][8][9]25], but no attempts have been made to detect anaesthesia-induced immunodepression in fish. The present paper then, provides some novel information based on …”

“…In many cases their e#ectiveness depends on the procedure used, because severe anaesthesia may itself induce a stress response in fish [3,4], and stress is known to be a risk factor that may lead to immunodepression, thus facilitating subsequent infections [2,5]. While immunodepressive e#ects caused by anaesthesia have frequently been described in mammals [6][7][8][9], there are no studies on this topic in fish.…”

“…In mammals, anaesthetic agents are known to depress phagocytic functions such as mobilisation, attachment, chemotactic motility, engulfment and intracellular killing [8]. A progressive decline in the expression of endogenous sugar receptors, such as mannose-specific receptors, on granulocytes during anaesthesia has been detected [8,25].…”

“…In mammals, anaesthetic agents are known to depress phagocytic functions such as mobilisation, attachment, chemotactic motility, engulfment and intracellular killing [8]. A progressive decline in the expression of endogenous sugar receptors, such as mannose-specific receptors, on granulocytes during anaesthesia has been detected [8,25]. Considering that carbohydrate-lectin interactions play an important role in the activities of phagocytic cells, the above authors suggested that this depletion of lectin-like receptors could be the connection between anaesthesia and depression of the phagocytic function.…”

Changes of Glycoprotein Patterns in Sera of Humans under Stress

“…However, only few studies have been undertaken to evaluate stress-re-Brought to you by | Michigan State University Authenticated Download Date | 7/2/15 9:52 AM lated changes of specific glycoproteins and lectins (28)(29)(30)(31)(32)(33)(34). However, only few studies have been undertaken to evaluate stress-re-Brought to you by | Michigan State University Authenticated Download Date | 7/2/15 9:52 AM lated changes of specific glycoproteins and lectins (28)(29)(30)(31)(32)(33)(34).…”