Reduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

“…[36][37][38][39][40][41][42][43] We have previously reported insufficiency in the hemodynamics and vasoreactivity of the PCA, the main supplying vessel of the posterior visual pathways, in POAG. 19 A recent study reported reduction in the resting CBF in the primary visual cortex and its correlation with the loss of visual function in patients with POAG. 44 These findings are evidence of widespread involvement of the cerebrovascular system in glaucoma.…”

“…In the CNS, changes in the function, structure, or metabolism of neurons may lead to disturbance of the local CBF through neurovascular coupling. 18,19,35 We hypothesized that glaucomatous neurodegeneration in the brain may be accompanied by cerebral vascular deficiency. Cerebrovascular insufficiency in glaucoma has been reported by a few previous clinical studies, and includes abnormal CBF patterns, diffuse WM lesions, lacunar infarcts, and hemodynamic disturbances in the middle cerebral artery (MCA).…”

“…This result is consistent with our previous publication of decreased vasoreactivity in bilateral PCAs to a reversing checkerboard stimulation presented to the central preserved ''normal'' visual field in patients with POAG. 19 In an earlier functional MRI study, a 58 hemifield reversing checkerboard was presented monocularly to the central apparently ''normal'' visual field of patients with asymmetric POAG. A significant decrease in blood oxygenation level-dependent (BOLD) signal changes was observed in the occipital poles when evoked by the glaucomatous eyes as compared to the contralateral, less affected fellow eye.…”

“…In a previous study we reported an insufficiency in the hemodynamics in the posterior cerebral artery (PCA) of patients with primary open-angle glaucoma (POAG). 19 In the present study, we further investigate the structural and CBF changes in the brain of POAG patients using high-resolution anatomical MRI and arterial spin labeling (ASL) perfusion MRI.…”

Associations between primary open angle glaucoma, Alzheimer’s disease and vascular dementia: record linkage study

“…For example, diabetes mellitus and systemic hypertension are strong risk factors for vascular dementia,21 22 and may also increase the risk of POAG 23. In addition, previous research has demonstrated that patients with OAG have reduced cerebrovascular blood flow and vasoreactivity compared with controls,24 and that patients with NTG in particular have a high incidence of macrovascular and microvascular abnormalities 16…”