Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia

Takayanagi, Mizuho; Wentz, Jacqueline; Takayanagi, Yoichiro; Schretlen, David J.; Ceyhan, Elvan; Wang, Lei; Suzuki, Michio; Sawa, Akira; Barta, Patrick E.; Ratnanather, J. Tilak; Cascella, Nicola G.

doi:10.1016/j.schres.2013.07.036

Cited by 43 publications

(37 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cascella et al [94], in a study based on VBM analysis of MRI data, found in DS, as compared to NDS subjects, decreased gray matter volume in temporal structures, but also in several other brain areas including the insula, anterior cingulate, medial prefrontal putamen and precuneus. This finding is in line with another study that reported right hemispheric anterior cingulate volume reduction in DS patients, as compared to NDS patients and healthy controls [95]. However, more recently, Ozdemir et al [96] used VBM analysis of MRI images and found no evidence of reduced gray matter volumes in DS versus NDS subjects.…”

Section: Structural Neuroimaging Findingssupporting

confidence: 87%

Neurobiological background of negative symptoms

Galderisi

Merlotti

Mucci

2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct. We tried to review the findings published to date investigating neurobiological abnormalities after reducing the heterogeneity of the negative symptoms construct. The literature in electronic databases as well as citations and major articles are reviewed with respect to the phenomenology, pathology, genetics and neurobiology of schizophrenia. We searched PubMed with the keywords "negative symptoms," "deficit schizophrenia," "persistent negative symptoms," "neurotransmissions," "neuroimaging" and "genetic." Additional articles were identified by manually checking the reference lists of the relevant publications. Publications in English were considered, and unpublished studies, conference abstracts and poster presentations were not included. Structural and functional imaging studies addressed the issue of neurobiological background of negative symptoms from several perspectives (considering them as a unitary construct, focusing on primary and/or persistent negative symptoms and, more recently, clustering them into factors), but produced discrepant findings. The examined studies provided evidence suggesting that even primary and persistent negative symptoms include different psychopathological constructs, probably reflecting the dysfunction of different neurobiological substrates. Furthermore, they suggest that complex alterations in multiple neurotransmitter systems and genetic variants might influence the expression of negative symptoms in schizophrenia. On the whole, the reviewed findings, representing the distillation of a large body of disparate data, suggest that further deconstruction of negative symptomatology into more elementary components is needed to gain insight into underlying neurobiological mechanisms.

show abstract

Section: Structural Neuroimaging Findingssupporting

confidence: 87%

Neurobiological background of negative symptoms

Galderisi

Merlotti

Mucci

2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Based on this tissue segmentation, the cortical thickness was calculated using Labeled Cortical Distance Mapping (LCDM). LCDM is a well-validated, high resolution approach that has successfully been used to characterize difference in cortical thickness in psychopathology including Alzheimer’s and schizophrenia (Miller et al, 2003; Ratnanather et al, 2013, 2014; Takayanagi et al, 2013; Wang et al, 2007; Karnik-Henry et al, 2012). The LCDM technique characterizes cortical morphometry in terms of the distribution of labeled distances of GM voxels from the grey matter/white matter (GM/WM) surface (Ceyhan et al, 2011, 2013; Miller et al, 2000; Ratnanather et al, 2001).…”

Section: Methodsmentioning

confidence: 99%

Ventromedial prefrontal cortex thinning in preschool-onset depression

Marrus

Belden

Nishino

et al. 2015

Journal of Affective Disorders

View full text Add to dashboard Cite

Background The ventromedial prefrontal cortex (VMPFC) is a key center of affect regulation and processing, fundamental aspects of emotional competence which are disrupted in mood disorders. Structural alterations of VMPFC have consistently been observed in adult major depression and are associated with depression severity, yet it is unknown whether young children with depression demonstrate similar abnormalities. We investigated cortical thickness differences in the VMPFC of children with a history of preschool-onset depression (PO-MDD). Methods Participants in a longitudinal study of PO-MDD underwent structural brain imaging between the ages of 7 to 12 years. Using local cortical distance metrics, cortical thickness of the VMPFC was compared in children with and without a history of PO-MDD. Results Children previously diagnosed with PO-MDD (n=34) had significantly thinner right VMPFC versus children without a history of PO-MDD [(n=95); F(1,126)=5.97, p=0.016)]. This effect was specific to children with a history of PO-MDD vs. other psychiatric conditions and was independent of comorbid anxiety or externalizing disorders. Decreases in right VMPFC thickness were predicted by preschool depressive symptoms independent of depressive symptoms in school age. Limitations Results are cross-sectional and cannot distinguish whether thinner right VMPFC represents a vulnerability marker of MDD, consequence of MDD, or marker of remitted MDD. Longitudinal imaging is needed to contextualize how this difference relates to normative VMPFC structural development. Conclusions Onset of depression at preschool age was associated with decreased cortical thickness of right VMPFC. This finding implicates the VMPFC in depression from very early stages of brain development.

show abstract

“…Neuroimaging techniques have been extensively studied over the past years, and there is now a considerable number of studies including structural and functional magnetic resonance imaging that aim to develop new diagnostic markers for schizophrenia. Relevant findings of neuroimaging studies in patients with schizophrenia include gray (Glahn et al, 2008) and white (Takayanagi et al, 2013;Bracht et al, 2014) precise nature of the underlying neuropathology of the disorder (Fornito et al, 2009). In this context, optical coherence tomography (OCT), a non-invasive imaging technique, provides reproducible, high-resolution cross-sectional imaging of the retinal nerve fiber layer (RNFL) and optic nerve head topography, providing an objective tool to diagnose axonal damage and thus constituting a "window into the brain" (London et al, 2013).…”

Section: Introductionmentioning

confidence: 99%