Red light-driven photoelectrochemical biosensing for ultrasensitive and scatheless assay of tumor cells based on hypotoxic AgInS2 nanoparticles

Li, Jing; Lin, Xiaofeng; Zhang, Zhiyi; Tu, Wenwen; Dai, Zhihui

doi:10.1016/j.bios.2018.09.096

Cited by 47 publications

(30 citation statements)

References 43 publications

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“…In addition, QDs have been functionalized for biomedical applications. AgInS 2 was functionalized with sgc8c aptamer to sense tumor cells [ 87 ], methotrexate for drug delivery [ 88 ], and DNA for potential biomedical applications [ 89 ]. Therefore, the functionalization of these novel nanoparticles is an opportunity area with several applications.…”

Section: Sensing Schemesmentioning

confidence: 99%

Ternary Quantum Dots in Chemical Analysis. Synthesis and Detection Mechanisms

et al. 2021

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Ternary quantum dots (QDs) are novel nanomaterials that can be used in chemical analysis due their unique physicochemical and spectroscopic properties. These properties are size-dependent and can be adjusted in the synthetic protocol modifying the reaction medium, time, source of heat, and the ligand used for stabilization. In the last decade, several spectroscopic methods have been developed for the analysis of organic and inorganic analytes in biological, drug, environmental, and food samples, in which different sensing schemes have been applied using ternary quantum dots. This review addresses the different synthetic approaches of ternary quantum dots, the sensing mechanisms involved in the analyte detection, and the predominant areas in which these nanomaterials are used.

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Section: Sensing Schemesmentioning

confidence: 99%

Ternary Quantum Dots in Chemical Analysis. Synthesis and Detection Mechanisms

et al. 2021

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“…The principle of electrochemical detection is to modify the electrode using nanomaterials and cancer cell specific aptamer, and CTC is bonded to aptamer (on the electrode surface), which will cause the current/electrochemiluminescence (ECL)/photoelectrochemical (PEC) signal to decrease or EC impedance spectroscopy (EIS) signal to increase [27,[92][93][94][95][96]. By establishing a linear relationship between the change and the number of CTC, the quantification can be realized.…”

Section: Electrochemical Detection Of Ctcmentioning

confidence: 99%

“…After CCRF-CEM cell is connected to aptamers on AgInS 2 NPs, the photocurrent is significantly reduced, and CTC can be detected. Its linear range is from 1.5 × 10 2 to 3.0 × 10 5 cells mL −1 , and the LOD is 16 cells mL −1 ( Figure 3C) [93]. In order to further improve the detection sensitivity, Wang et al prepared nanomaterials-plasmonic gold nanostars (AuNSs), modified sgc8c aptamer on its surface and fixed it on glassy carbon (GC) electrode.…”

Section: Direct Assaysmentioning

confidence: 99%

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Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Han

Sun

et al. 2020

Sensors

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Circulating tumor cells (CTCs) are tumor cells that escaped from the primary tumor or the metastasis into the blood and they play a major role in the initiation of metastasis and tumor recurrence. Thus, it is widely accepted that CTC is the main target of liquid biopsy. In the past few decades, the separation of CTC based on the electrochemical method has attracted widespread attention due to its convenience, rapidness, low cost, high sensitivity, and no need for complex instruments and equipment. At present, CTC detection is not widely used in the clinic due to various reasons. Point-of-care CTC detection provides us with a possibility, which is sensitive, fast, cheap, and easy to operate. More importantly, the testing instrument is small and portable, and the testing does not require specialized laboratories and specialized clinical examiners. In this review, we summarized the latest developments in the electrochemical-based CTC detection and point-of-care CTC detection, and discussed the challenges and possible trends.

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“…These biosensors demonstrated a linear range of 63–1.0 × 10 7 cells mL −1 and limit-of-detection of 21 cells mL −1 . Lymphoblast (CCRF-CEM) cells were also detected based on steric hindrance in a PEC biosensor (Li et al, 2019). These cells were captured using hairpin DNA targeting overexpressed protein tyrosine kinase-7 on their surface.…”

Section: Transduction Mechanismmentioning

confidence: 99%

Affinity-Based Detection of Biomolecules Using Photo-Electrochemical Readout

et al. 2019

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Detection and quantification of biologically-relevant analytes using handheld platforms are important for point-of-care diagnostics, real-time health monitoring, and treatment monitoring. Among the various signal transduction methods used in portable biosensors, photoelectrochemcial (PEC) readout has emerged as a promising approach due to its low limit-of-detection and high sensitivity. For this readout method to be applicable to analyzing native samples, performance requirements beyond sensitivity such as specificity, stability, and ease of operation are critical. These performance requirements are governed by the properties of the photoactive materials and signal transduction mechanisms that are used in PEC biosensing. In this review, we categorize PEC biosensors into five areas based on their signal transduction strategy: (a) introduction of photoactive species, (b) generation of electron/hole donors, (c) use of steric hinderance, (d) in situ induction of light, and (e) resonance energy transfer. We discuss the combination of strengths and weaknesses that these signal transduction systems and their material building blocks offer by reviewing the recent progress in this area. Developing the appropriate PEC biosensor starts with defining the application case followed by choosing the materials and signal transduction strategies that meet the application-based specifications.

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Red light-driven photoelectrochemical biosensing for ultrasensitive and scatheless assay of tumor cells based on hypotoxic AgInS2 nanoparticles

Cited by 47 publications

References 43 publications

Ternary Quantum Dots in Chemical Analysis. Synthesis and Detection Mechanisms

Ternary Quantum Dots in Chemical Analysis. Synthesis and Detection Mechanisms

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Affinity-Based Detection of Biomolecules Using Photo-Electrochemical Readout

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