Red Ginseng Treatment for Two Weeks Promotes Fat Metabolism during Exercise in Mice

Hwang, Hyeon‐Jong; Kim, Jisu; Park, Jonghoon; Yun, Hea-Yeon; Cheon, Woo-Kwang; Lee, Chi H.; Suh, Heajung; Lim, Kiwon

doi:10.3390/nu6051874

Cited by 22 publications

(33 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the end of the experimental protocol, the resting metabolic rate was measured by indirect calorimetry, using an open-circuit apparatus as previously described. [19][20][21][22] The flow rate was kept constant at 1.2 L/min and measured for 24 h. Mice had free access to food and water. O 2 uptake and CO 2 production were analyzed using a mass spectrometer (RL-600; Alco System, Chiba, Japan) and switching system (ANI6-A-S; Alco System).…”

Section: Respiratory Gas Analysismentioning

confidence: 99%

High-Fat Diet Increases Fat Oxidation and Promotes Skeletal Muscle Fatty Acid Transporter Expression in Exercise-Trained Mice

Yun

Lee

Jeong

2020

Journal of Medicinal Food

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of a high-fat diet (HFD) on energy substrate utilization during long-term endurance exercise in mice. Male ICR mice (n = 32; 6 weeks old) were divided into two groups: low-fat diet (LFD, n = 16) and HFD (n = 16) and acclimatized to LFD or HFD feeding over 12 weeks. After 12 weeks, the two dietary groups were each divided into two groups with or without exercise (EX): LF-CON, LF-EX, HF-CON, and HF-EX groups. The exercise groups were trained to run on a treadmill for 12 weeks. At the end of the experimental protocol, energy metabolism in the whole body was measured at rest for 24 h and during exercise for 1 h using respiratory gas analysis. Furthermore, molecules involved in skeletal muscle fat metabolism were analyzed. Substrate utilization for energy metabolism in the whole body indicated that fat utilization was high in HFD intake. Notably, when HFD intake and exercise were combined, fat utilization was markedly increased during endurance exercise. In contrast, exercise showed no effect when combined with LFD intake. The gene expressions of Fat/Cd36, Fatp1, Fabp-pm, and Cpt1 were upregulated by HFD intake, with Fat/Cd36 and Cpt1 considerably elevated during long-term endurance exercise. In contrast, exercise showed no effect when combined with LFD intake. These results suggest that HFD intake effectively increased fat utilization as an energy substrate during long-term endurance exercise.KEYWORDS: endurance exercise fat oxidation fatty acid transporter high-fat diet skeletal muscle *These authors contributed equally to this work.

show abstract

Section: Respiratory Gas Analysismentioning

confidence: 99%

High-Fat Diet Increases Fat Oxidation and Promotes Skeletal Muscle Fatty Acid Transporter Expression in Exercise-Trained Mice

Yun

Lee

Jeong

2020

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…Our recent study involved the use of a metabolic chamber, and administration of red ginseng (1 g/kg, including 19.64 mg ginsenosides/g red ginseng extract) treatment 1 h before exercise training. The combination of ginseng with 2 wk of endurance training (70% of VO2 max) increased fat oxidation in the initial 20-min phase in mice, and a glycogen-saving effect was observed during the 1-h running exercise (152).…”

Section: Ginseng and Endurance Performancementioning

confidence: 97%

Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity

Kim

Park

Lim

2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

Self Cite

View full text Add to dashboard Cite

Athletes make great efforts to increase their endurance capacity in many ways. Using nutrition supplements for stimulating lipolysis is one such strategy to improve endurance performance. These supplements contain certain ingredients that affect fat metabolism; furthermore, in combination with endurance training, they tend to have additive effects. A large body of scientific evidence shows that nutrition supplements increase fat metabolism; however, the usefulness of lipolytic supplements as ergogenic functional foods remains controversial. The present review will describe the effectiveness of lipolytic supplements in fat metabolism and as an ergogenic aid for increasing endurance exercise capacity. There are a number of lipolytic supplements available on the market, but this review focuses on natural ingredients such as caffeine, green tea extract, L-carnitine, Garcinia cambogia (hydroxycitric acid), capsaicin, ginseng, taurine, silk peptides and octacosanol, all of which have shown scientific evidence of enhancing fat metabolism associated with improving endurance performance. We excluded some other supplements owing to lack of data on fat metabolism or endurance capacity. Based on the data in this review, we suggest that a caffeine and green tea extract improves endurance performance and enhances fat oxidation. Regarding other supplements, the data on their practical implications needs to be gathered, especially for athletes.

show abstract

“…Extracts of red and white ginseng contain different ginsenosides 12 . Previous studies demonstrated that RG contain a large dose of ginsenosides and saponin through specific manufacturing processes such as steaming and drying ginseng 13 . Together with ginsenoside Rg3, a nitrogen-containing component and ginsenoside 20(R)-Rh1 were detected as characteristic components of RG, whereas malonyl ginsenoside Rb1/ isomer and malonyl ginsenoside Rg1/isomer were found to be characteristic components of WG 14 .…”

Section: Red Ginseng As An Ergogenic Aidmentioning

confidence: 99%

Red ginseng as an ergogenic aid: A systematic review of clinical trials

Lee¹,

Lee²,

Jung³

2016

Journal of Exercise Nutrition &Amp; Biochemistry

View full text Add to dashboard Cite

An ergogenic aid can be defined as an equipment, technique, and substance used for enhancing sports performance. Ergogenic aids can be classified into different forms such as nutritional, pharmacological, and physiological aids. They range from use of accepted techniques such as high altitude training to consumption of illegal substances such as steroid. The efficacy of many of these is controversial, whereas the side effects are evident. An herb is a plant or plant part used for its scent, flavor, or therapeutic properties. In general, taking herb medication is considered as a safe practice. There are different forms of herbs such as tablets, capsules, powders, and fresh leaf. People use herbal medicines to maintain or improve their health. Herbs have been used to improve performance (both endurance and strength), facilitate recovery from work and exercise, maintain health, build muscle mass, and reduce body fat 1-3 . Ginseng is one of the most widely used herbs for human physical and mental performance, which includes several species and is prepared by various methods 4 .The term 'ginseng' usually refers to the species Panax ginseng, known as Korean ginseng or Chinese ginseng. Ginseng root extracts have long been used in traditional oriental medicine to restore energy and enhance well-being 1 . Ginseng is a perennial herb which is indigenous to Korea, China (Panax ginseng C.A. Meyer), Himalaya (Panax pseudo-ginseng), Vietnam (e.g. Panax vietnamensis), Japan (e.g. Panax japonicus), and North America (Panax quinquefolium). Ginseng is available in many forms: whole root, root powder (white ginseng), steamed root powder (red ginseng), teas, tinctures, and standardized root extracts containing known and reproducible amounts of ginsenosides. The recognized primary active components of ginseng are a group of 30 different triterpene saponins, also referred to as ginsenosides, which vary in content and relative proportions among different species of ginseng 5,6 .In exercise and sports science, ginseng is believed to be a physical performance enhancer 1 . Chen et al (2012) 1 reported that Panax ginseng supplements may enhance physical and mental performance if taken over a long enough period of time and in sufficient doses. Panax ginseng, when administered at an adequate dosage (between 200 and 400 g/day) for a period of longer than 8 weeks may improve physical

show abstract

Red Ginseng Treatment for Two Weeks Promotes Fat Metabolism during Exercise in Mice

Cited by 22 publications

References 19 publications

High-Fat Diet Increases Fat Oxidation and Promotes Skeletal Muscle Fatty Acid Transporter Expression in Exercise-Trained Mice

High-Fat Diet Increases Fat Oxidation and Promotes Skeletal Muscle Fatty Acid Transporter Expression in Exercise-Trained Mice

Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity

Red ginseng as an ergogenic aid: A systematic review of clinical trials

Contact Info

Product

Resources

About