Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity

Abstract

Athletes make great efforts to increase their endurance capacity in many ways. Using nutrition supplements for stimulating lipolysis is one such strategy to improve endurance performance. These supplements contain certain ingredients that affect fat metabolism; furthermore, in combination with endurance training, they tend to have additive effects. A large body of scientific evidence shows that nutrition supplements increase fat metabolism; however, the usefulness of lipolytic supplements as ergogenic functional foods remains controversial. The present review will describe the effectiveness of lipolytic supplements in fat metabolism and as an ergogenic aid for increasing endurance exercise capacity. There are a number of lipolytic supplements available on the market, but this review focuses on natural ingredients such as caffeine, green tea extract, L-carnitine, Garcinia cambogia (hydroxycitric acid), capsaicin, ginseng, taurine, silk peptides and octacosanol, all of which have shown scientific evidence of enhancing fat metabolism associated with improving endurance performance. We excluded some other supplements owing to lack of data on fat metabolism or endurance capacity. Based on the data in this review, we suggest that a caffeine and green tea extract improves endurance performance and enhances fat oxidation. Regarding other supplements, the data on their practical implications needs to be gathered, especially for athletes.

Effects of fasted vs fed‐state exercise on performance and post‐exercise metabolism: A systematic review and meta‐analysis

“…Investigating novel diet‐exercise interactions holds relevance for the sports nutrition sphere, as optimizing metabolic and training adaptations to exercise is a critical determinant of athletic performance . Moreover, current literature has assessed the efficacy of combining nutritional and exercise interventions to improve metabolic health biomarkers including insulin sensitivity, glucose, and lipid metabolism …”

“…1,2 Moreover, current literature has assessed the efficacy of combining nutritional and exercise interventions to improve metabolic health biomarkers including insulin sensitivity, glucose, and lipid metabolism. 3,4 Recently, fasting-based interventions such as intermittent fasting have garnered interest as alternatives to conventional dietary strategies for improving metabolic biomarkers in both healthy and clinical populations. 5,6 This is based on the hypothesis that such interventions act on similar biological pathways to conventional methods, while potentially being a more feasible long-term approach.…”

“…1,2 Moreover, current literature has assessed the efficacy of combining nutritional and exercise interventions to improve metabolic health biomarkers including insulin sensitivity, glucose, and lipid metabolism. 3,4 Recently, fasting-based interventions such as intermittent fasting have garnered interest as alternatives to…”

Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice

“…Carbohydrate and fat metabolism occur in the muscles during exercise [14]. Skeletal muscles generate energy using energy sources source such as glucose, lactate, and fatty acids [4, 15].…”

Capsaicin Analog Supplementation is not Effective to Improve 10-km Running Time-Trial Performance in Amateur Athletes: A Randomized, Crossover, Double-Blind and Placebo-Controlled Study

“…Several animal studies showed that acute capsaicin supplementation was e cient to improve endurance capacity (exercises protocols between 30-60 minutes of moderate aerobic exercise) (Kim et al, 2016). It might be related in part to an increase in hepatic glycogen content, being considered an important mechanism for energy homeostasis and via activation of TRPV1 due to capsaicin supplementation and improvements of energy metabolism by increasing lipolysis saving and maintaining muscle glycogen reserves (Kim et al, 2016).…”