Red cell incompatibility due to antibody against ingredient in column matrix: A rare entity

Rajendran, Arun; Krishna, G Deepthi; Suresh, Beena; Babu, KV Sreedhar; Jothibai, DS

doi:10.15380/2277-5706.jcsr.15.013

Cited by 4 publications

(5 citation statements)

References 13 publications

(10 reference statements)

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“…where the patient had an antibody against the ingredients of the matrix of column agglutination. [ 10 ] Many authors described similar findings like that of ours[ 3 10 11 12 13 ][ Table 1 ].…”

Section: Discussionsupporting

confidence: 82%

A rare case of antibody against enhancement media interfering with crossmatching: A case report and review of literature

Anuragaa

Sahoo

Abhishekh

et al. 2021

Asian J Transfus Sci

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Detection of clinically significant alloantibodies during pretransfusion testing is essential before any blood transfusion. Sometimes, clinically insignificant antibodies unrelated to blood group antigen may interfere with routine testing. Their interpretation is often made only after tedious immunohematology workup resulting in the exclusion of all possible clinically significant antibodies. We encountered such incidence which interfered with crossmatching. In our case, direct antiglobulin test was negative, indirect antiglobulin test and autocontrol were positive with pan-reactive antibody screening test, and group-specific units were incompatible. After meticulous workup, we could find that these antibodies were directed against the enhancement media, low-ionic strength solution in this case.

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Section: Discussionsupporting

confidence: 82%

A rare case of antibody against enhancement media interfering with crossmatching: A case report and review of literature

Anuragaa

Sahoo

Abhishekh

et al. 2021

Asian J Transfus Sci

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“…Antibodies against commercial blood grouping antisera, various enhancement media (LISS, polyethylene glycol), and ingredients of column matrix of gel card are found in literature and are known to give an erroneous reaction in immunohematological workup. [310] Sometimes, these antibodies may show blood group specificity, for example, paraben in LISS additive solution that shows Jka and Rh specificity. [1011] However, no specific pattern was observed in our antibody screening and identification test.…”

Section: Discussionmentioning

confidence: 99%

“…[310] Sometimes, these antibodies may show blood group specificity, for example, paraben in LISS additive solution that shows Jka and Rh specificity. [1011] However, no specific pattern was observed in our antibody screening and identification test. The possibility of drug-induced antibody was ruled out from medication history and change in serologic reaction with washed reagent red cells.…”

Section: Discussionmentioning

confidence: 99%

Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology

Kandasamy

Shastry

Chenna

et al. 2018

Asian J Transfus Sci

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Detection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents and human resources. We report one such nuisance antibody detected in an antenatal female that showed pan reaction with antibody screening and identification panel red cells including auto control but was compatible with group-specific donor units. Direct antiglobulin test was positive with no hematological evidence of bleeding. Repeat antibody screening test performed after washing the panel red cells and use of panel cells from different manufacturer showed negative reaction raising the suspicion of antibody specificity against chemical constituents in suspension medium of panel cells. Interpretation of nonspecific antibodies as to what they really are demands extensive immunohematological work-up and causes a delay in issue of blood components to the recipient.

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“…Preservatives Na-azide and esters of parabens, and antibiotics are added to commercially available LISS(C-LISS)® to prevent microbial growth [24][25][26]. Th e additives used for the storage, preservation, and coloring of blood bank reagents can be a source of false positive agglutination reactions [27]. Agglutination of red blood cells used for blood typing, antibody detection and identifi cation may be related to the presence of these materials in blood bank reagents.…”

Section: The Topic Position In Scientific/professional Publicmentioning

confidence: 99%

“…Agglutination of red blood cells used for blood typing, antibody detection and identifi cation may be related to the presence of these materials in blood bank reagents. Th ese substances include acrifl avin and other dyes; antibiotics, such as penicillin and neomycin; EDTA; caprylate; and occasionally saline [27,28]. Th ere were examples of anti-Jka that react only when preservatives such as p-hydroxybenzoic acid (parabens) or related compounds are present in the reaction mixture [29][30][31].…”

Section: The Topic Position In Scientific/professional Publicmentioning

confidence: 99%

The role of the Kidd-antibodies in posttransfusion reactions

Nikolić¹,

Čolak²,

Kadija³

et al. 2019

Hosp Pharm Int Multi J

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Topic: The Kidd blood group (Jk) was discovered in 1951 and according to International Society for blood transfusion (ISBT) the Kidd (Jk) blood group is registered under the number 009. Antigens of the Kidd system are detected only on RBCs and kidney. Incompatibile transfusion in Jk blood group can provoke sensitization and appearance of anti-Jka or anti-Jkb antibodies. Jk antibodies are common cause of delayed hemolytic transfusion reactions (DHTRs). Although Kidd antibodies can lead to acute reactions, kidney damage and hemoglobinuria are very rare. More important is Kidd-antibody ability for delayed hemolytic reactions. The aim is to underline Jka antibodies laboratory characteristics, their role in delayed posttransfusion reactions and possible complications of blood transfusions. The topic position in scientifi c/professional public: Kidd-antibodies, usually, destroy transfused red cells after a variable period of between 7 and 21 days. DHTR is the result of anti-Jka antibodies tendency to fall rapidly to undetectable levels even after incompatible transfusion. Anti-Jka has been reported as reason for kidney transplant rejection. There were examples of anti-Jka that react only when preservatives such as p-hydroxybenzoic acid (parabens), Na-azide or related compounds, antibiotics are present in the reaction mixture. Also, patient's therapy with antibiotics and monoclonal antibodies could cause false positive RBC antibody. Further action needed for better topic covering in future: Except in life threatening condition, reduction of allogenic blood transfusion is recommended. Increase the number of autologous transfusions in all cases when the patient's clinical condition allows. Antigen-free RBC ie universal RBC would be the best choice for transfusion. It is essential to perform extended erythrocyte phenotyping prior to initiation of monoclonal antibodies therapy. As a minimum blood typing for Rh, K, Jka,Jkb, Fya, Fyb and Ss antigens should be done for every patient who is planned to be treated with monoclonal antibodies.Overcoming this problem is very important for patients who are transfusion-dependent or candidates for monoclonal antibody therapy, or candidates for kidney transplantation.

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Red cell incompatibility due to antibody against ingredient in column matrix: A rare entity

Cited by 4 publications

References 13 publications

A rare case of antibody against enhancement media interfering with crossmatching: A case report and review of literature

A rare case of antibody against enhancement media interfering with crossmatching: A case report and review of literature

Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology

The role of the Kidd-antibodies in posttransfusion reactions

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