Red cell and plasma protein labeling with 113mIn

Adatepe, Mustafa H.; Penkoske, P.; Amberg, A. van; Wharton, T.; Evens, Ronald G.; Potchen, E. James

doi:10.1016/0020-708x(71)90175-x

Cited by 15 publications

(8 citation statements)

References 2 publications

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“…administration. [37][38][39] This statement is consistent with the previously reported mouse serum stability tests for 111 In-labelled micelles equivalent to the ones used in our experiments. 31 Fig.…”

Section: In Vivo Biodistribution Of Ps-peo Micellessupporting

confidence: 93%

In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

et al. 2016

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Understanding how nanoparticle properties such as size, morphology and rigidity influence their circulation time and biodistribution is essential for the development of nanomedicine therapies. Herein we assess the influence of morphology on cellular internalization, in vivo biodistribution and circulation time of nanocarriers using polystyrene-b-poly(ethylene oxide) micelles of spherical and elongated morphology. The glassy nature of polystyrene guarantees the morphological stability of the carriers in vivo and by encapsulating Indium-111 in their core, an assessment of the longitudinal in vivo biodistribution of the particles in healthy mice is performed with single photon emission computed tomography imaging. Our results show prolonged blood circulation, longer than 24 hours, for all micelle morphologies studied. Dynamics of micelle accumulation in the liver and other organs of the reticuloendothelial system show a size-dependent nature and late stage liver clearance is observed for the elongated morphology. Apparent contradictions between recent similar studies can be resolved by considering the effects of flexibility and degradation of the elongated micelles on their circulation time and biodistribution.

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Section: In Vivo Biodistribution Of Ps-peo Micellessupporting

confidence: 93%

In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

et al. 2016

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“…12 Indium-111(III) is also present in a transferrinbound form. 5,6 In the present study, it can be said that the much higher retention of "In(III) than 67 Ga(III) in blood is supported by the results, reported by Hara,l° that the binding affinity of indium for transferrin was stronger than that of gallium. At 24 h after the injection, 111 In(III) uptake by liver and spleen were greater than 67 Ga(III) uptake.…”

Section: Discussionsupporting

confidence: 77%

“…BECAUSE " 1 1n(III) is taken up by malignant tissues, it has been widely used for tumor-imaging.l Ever since the observation of 67 Ga accumulation in tumors, 2 67 Ga has also been used for the detection of various tumors.3 It has been reported, however, that the distribution of lllIn(III) differs from that of 67 Ga(III) in tumor-bearing mice.¢ In the blood 111 In(III) is present in a transferrin-bound form, 5,6 and 67 Ga(III) is also exclusively bound with transferrin both in vitro and in vivo. [7][8][9] Harm° reported that the binding affinity of indium for transferrin was stronger than that of gallium.…”

Section: Introductionmentioning

confidence: 99%

111In (III) uptake by inflammatory and normal tissues

et al. 1989

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Tissue distributions of 111In (III) in the rats bearing granuloma, inflammatory tissue induced by turpentine oil, were compared with those of 67Ga. The results showed that indium-111 resembles 67Ga in the manner of uptake by inflammatory and normal soft tissues. The effect of cold-InCl3 on 111In (III) uptake showed that transferrin is not involved in the uptake of 111In (III) into inflammatory tissues but is involved in the uptake into liver and spleen.

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“…Concerning the possibility that EME might have been present in the other conditions we studied (patients [8][9][10][11][12][13][14]: EME may occur in the spleen of patients with chronic lymphatic leukaemia (23) if this disease is associated with myelofibrosis ("secondary myelofibrosis"). An association with myelofibrosis was ruled out in our control group (pats.…”

Section: Discussionmentioning

confidence: 99%

“…An association with myelofibrosis was ruled out in our control group (pats. [8][9][10][11][12][13][14]. To our knowledge E M E has not been described in smouldering monocytic leukaemia (patient 8).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Extramedullary Erythropoiesis in the Spleen by a Semiquantitative Method Using Indium‐111

Rojer

Mulder

Nieweg

et al. 1978

Journal of Internal Medicine

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ABSTRACT. A semiquantitative method for evaluating the splenic uptake of 111In is described. With this method the uptake of indium in the spleen was significantly higher in seven patients with extramedullary erythropoiesis (EME) than in a control group of seven patients with comparable degrees of splenomegaly but without clinical and/or histological signs of EME. The discrimination between these groups could be further improved by also taking the degree of splenomegaly into account. It is concluded that the described technique is a valuable non‐invasive aid for establishing the presence of EME in the spleen.

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Red cell and plasma protein labeling with 113mIn

Cited by 15 publications

References 2 publications

In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT

111In (III) uptake by inflammatory and normal tissues

Analysis of Extramedullary Erythropoiesis in the Spleen by a Semiquantitative Method Using Indium‐111

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