Recurrence of Granular Corneal Dystrophy Type I Deposits Within Host Stroma After Non-Descemet Baring Anterior Lamellar Keratoplasty

Pantanelli, Seth; Herzlich, Alexandra A.; Yeaney, Gabrielle; Ching, Steven T.

doi:10.1097/ico.0000000000000267

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…Some suggest that GCD has an epithelial origin and may recur anteriorly [ 31 , 58 ]. This hypothesis has not been confirmed, though, as contradictory papers suggest otherwise, i.e., the role of residual keratocytes and the type of mutation have a role in the pattern of recurrence [ 57 , 71 , 72 ]. Pantanelli et al reported a case of GCD with a recurrence of the disease 3 years following an 8 mm DALK.…”

Section: Granular Dystrophymentioning

confidence: 99%

“…Granular corneal dystrophy (GCD) type 1 is an autosomal dominant disease with hyaline deposition in the corneal stroma [ 57 ]. In fact, it represents one of the most common hereditary corneal dystrophies with an autosomal dominant trait [ 58 ].…”

Section: Granular Dystrophymentioning

confidence: 99%

“…Anterior segment OCT demonstrated pre-Descemet hyaline deposits. PK was offered, and the corneal button histology confirmed that recurrent hyaline deposits were confined to the residual host stroma just anterior to the Descemet membrane, following Melles manual dissection; hence, residual keratocytes are still a source of recurrence [ 57 ]. Based on this observation, it may be inferred that Descemet-baring techniques are superior in removal of the residual host stromal cells.…”

Section: Granular Dystrophymentioning

confidence: 99%

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Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty

Ashena

Niestrata

Tavassoli

2023

Vision

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Corneal dystrophies are a group of non-inflammatory inherited disorders of the cornea. This review considers treatment options for epithelial-stromal and stromal corneal dystrophies: namely Reis–Bücklers, Thiel–Behnke, lattice, Avellino, granular, macular and Schnyder corneal dystrophies. Where there is visual reduction, treatment options may include either phototherapeutic keratectomy (PTK) or corneal transplantation. Due to the anterior location of the deposits in Reis-Bücklers and Thiel–Behnke dystrophies, PTK is considered the treatment of choice. For lattice, Avellino, granular and macular corneal dystrophies, PTK provides temporary visual improvement; however, with recurrences, repeat PTK or a corneal transplant would be needed. For Schnyder dystrophy, should treatment be required, PTK may be the preferred option due to the potential for recurrence of the disease in corneal transplantation. This review discusses the literature and evidence base for the treatment of corneal dystrophies in terms of visual outcomes and recurrence rate.

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Section: Granular Dystrophymentioning

confidence: 99%

Section: Granular Dystrophymentioning

confidence: 99%

Section: Granular Dystrophymentioning

confidence: 99%

See 1 more Smart Citation

Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty

Ashena

Niestrata

Tavassoli

2023

Vision

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The Corneal Disc

Roberts¹,

Thum²

2021

Lee's Ophthalmic Histopathology

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Granular corneal dystrophy recurrence at the posterior graft-host interface after type 1 big bubble deep anterior lamellar keratoplasty

Oke

Haddad

Lee

2020

American Journal of Ophthalmology Case Reports

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Purpose To describe our observations of granular corneal dystrophy (GCD) recurrence isolated to the posterior graft-host interface after type 1 big bubble (BB) deep anterior lamellar keratoplasty (DALK). Observations We performed a retrospective chart review of 3 eyes in 2 patients, and literature review to summarize GCD recurrence patterns after DALK. A 29-year-old man with GCD underwent DALK by type 1 BB technique. Three years following surgery, he was found to have recurrence of GCD deposits isolated to the posterior graft-host interface. Similarly, a 53-year-old woman with GCD underwent DALK by BB type 1 technique, and was noted to have trace residual deposits at the posterior graft-host interface that increased in number and size over the course of 6 years. Her fellow eye underwent DALK with type 2 BB formation, without evidence of graft-host interface recurrence over a four year period. Our literature review describes the recurrence patterns of 18 cases of GCD following DALK. Conclusions and importance DALK can be prone to GCD recurrence in the central posterior graft-host interface. Recurrent deposits isolated to the posterior graft-host interface following type 1 BB DALK supports the hypothesis that GCD recurrence may be due to residual pathologic keratocytes in the pre-Descemet layer (PDL).

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Recurrence of Granular Corneal Dystrophy Type I Deposits Within Host Stroma After Non-Descemet Baring Anterior Lamellar Keratoplasty

Cited by 7 publications

References 12 publications

Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty

Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty

The Corneal Disc

Granular corneal dystrophy recurrence at the posterior graft-host interface after type 1 big bubble deep anterior lamellar keratoplasty

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