Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty

Ashena, Zahra; Niestrata, Magdalena; Tavassoli, Shokufeh

doi:10.3390/vision7010022

Cited by 2 publications

(4 citation statements)

References 123 publications

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“…Surgical interventions including superficial keratectomy, anterior lamellar keratoplasty (ALK), penetrating keratoplasty (PK), and as a final option, keratoprosthesis. 37…”

Section: Gelatinous Drop-like Corneal Dystrophy (Gdld)mentioning

confidence: 99%

“…For recurrent erosions, refer to section on EBMD management. 37 For visually significant opacities, SK, PTK, and superficial anterior lamellar keratoplasty (SALK) may be performed. 38,39 Recurrence in the graft is common and may necessitate repeat interventions or possibly DALK.…”

Section: Reis-bücklers Corneal Dystrophy (Rbcd)mentioning

confidence: 99%

“…Table 3 outlines the management strategies for various corneal dystrophies. 28–51 Several corneal dystrophies including FCD, PACD, CCDF, and PDCD are typically asymptomatic and do not require treatment. The table provides a broad overview of general treatment approaches rather than an exhaustive description of all possible treatments.…”

Section: Principles Of Managementmentioning

confidence: 99%

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IC3D Classification of Corneal Dystrophies—Edition 3

Weiss,

Rapuano,

Seitz

et al. 2024

Cornea

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Purpose: The International Committee for the Classification of Corneal Dystrophies (IC3D) was created in 2005 to develop a new classification system integrating current information on phenotype, histopathology, and genetic analysis. This update is the third edition of the IC3D nomenclature. Methods: Peer-reviewed publications from 2014 to 2023 were evaluated. The new information was used to update the anatomic classification and each of the 22 standardized templates including the level of evidence for being a corneal dystrophy [from category 1 (most evidence) to category 4 (least evidence)]. Results: Epithelial recurrent erosion dystrophies now include epithelial recurrent erosion dystrophy, category 1 (COL17A1 mutations, chromosome 10). Signs and symptoms are similar to Franceschetti corneal dystrophy, dystrophia Smolandiensis, and dystrophia Helsinglandica, category 4. Lisch epithelial corneal dystrophy, previously reported as X-linked, has been discovered to be autosomal dominant (MCOLN1 mutations, chromosome 19). Classic lattice corneal dystrophy (LCD) results from TGFBI R124C mutation. The LCD variant group has over 80 dystrophies with non-R124C TGFBI mutations, amyloid deposition, and often similar phenotypes to classic LCD. We propose a new nomenclature for specific LCD pathogenic variants by appending the mutation using 1-letter amino acid abbreviations to LCD. Pre-Descemet corneal dystrophies include category 1, autosomal dominant, punctiform and polychromatic pre-Descemet corneal dystrophy (PPPCD) (PRDX3 mutations, chromosome 10). Typically asymptomatic, it can be distinguished phenotypically from pre-Descemet corneal dystrophy, category 4. We include a corneal dystrophy management table. Conclusions: The IC3D third edition provides a current summary of corneal dystrophy information. The article is available online at https://corneasociety.org/publications/ic3d.

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“…Surgical interventions including superficial keratectomy, anterior lamellar keratoplasty (ALK), penetrating keratoplasty (PK), and as a final option, keratoprosthesis. 37…”

Section: Gelatinous Drop-like Corneal Dystrophy (Gdld)mentioning

confidence: 99%

Section: Reis-bücklers Corneal Dystrophy (Rbcd)mentioning

confidence: 99%

Section: Principles Of Managementmentioning

confidence: 99%

See 1 more Smart Citation

IC3D Classification of Corneal Dystrophies—Edition 3

Weiss,

Rapuano,

Seitz

et al. 2024

Cornea

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“…7 The recurrence of RBCD after PTK has been well reported in the literature, although the baseline risk factors for recurrence have not been clearly identified. [8][9][10][11] Reports of recurrence after femtosecond laser-assisted anterior lamellar keratoplasty (FALK) are sparse.…”

mentioning

confidence: 99%

Clinical and Optical Coherence Tomography Correlation of Recurrence Patterns After Femtosecond Laser–Assisted Anterior Lamellar Keratoplasty in Reis–Bucklers Corneal Dystrophy

Chaurasia,

Mishra,

Murthy

et al. 2023

Cornea

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Purpose: The aim of this study was to report the clinical profile and patterns of recurrence after femtosecond laser–assisted anterior lamellar keratoplasty (FALK) in Reis–Bucklers corneal dystrophy. Methods: This is a case series of 5 eyes of 4 patients with Reis–Bucklers corneal dystrophy. Clinical images of recurrence were correlated with the high-resolution optical coherence tomography. Histopathologic examination of excised corneal samples was performed when possible. Results: The median time to recurrence was 2 (1–5) years after FALK. Of the 5 eyes, 1 eye had primary FALK, whereas 4 eyes had secondary interventions, which included previous phototherapeutic keratectomy (once in 1 eye and twice in 2 eyes), and previous penetrating keratoplasty, followed by phototherapeutic keratectomy (1 eye). Recurrence was noted at the level of the subepithelium. In addition, 1 eye showed interface deposits along with epithelial downgrowth at the graft–host bed. Conclusions: The 2 distinct patterns of recurrence noted were at the subepithelial region and the interface. The clinical patterns of recurrence favor an epithelial origin of recurrent deposits.

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Management of Stromal Corneal Dystrophies; Review of the Literature with a Focus on Phototherapeutic Keratectomy and Keratoplasty

Cited by 2 publications

References 123 publications

IC3D Classification of Corneal Dystrophies—Edition 3

IC3D Classification of Corneal Dystrophies—Edition 3

Clinical and Optical Coherence Tomography Correlation of Recurrence Patterns After Femtosecond Laser–Assisted Anterior Lamellar Keratoplasty in Reis–Bucklers Corneal Dystrophy

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