Recovery of human compound action potential using a paired-click stimulation paradigm

Ohashi, Toru; Ochi, Kentaro; Nishino, Hirohito; Kenmochi, Mutsumi; Yoshida, Katsumi

doi:10.1016/j.heares.2004.12.001

Cited by 25 publications

(16 citation statements)

References 33 publications

(63 reference statements)

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“…The effects of high stimulus rate on the CAP have been extensively investigated in normal hearing adults and consist of CAP attenuation to approximately the same extent as that found in the present study (Eggermont and Odenthal, 1974b;Charlet de Sauvage and Aran, 1976;Wilson and Bowker, 2002;Ohashi et al, 2005). In contrast, few papers have addressed the issue of the effects of high stimulus rates on the SP amplitude.…”

Section: Adaptation Of Ecochg Potentials In Controlssupporting

confidence: 63%

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Santarelli

Starr

Michalewski

et al. 2008

Clinical Neurophysiology

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Objective: Transtympanic electrocochleography (ECochG) was recorded bilaterally in children and adults with auditory neuropathy (AN) to evaluate receptor and neural generators. Methods: Test stimuli were clicks from 60 to 120 dB p.e. SPL. Measures obtained from eight AN subjects were compared to 16 normally hearing children. Results: Receptor cochlear microphonics (CMs) in AN were of normal or enhanced amplitude. Neural compound action potentials (CAPs) and receptor summating potentials (SPs) were identified in five AN ears. ECochG potentials in those ears without CAPs were of negative polarity and of normal or prolonged duration. We used adaptation to rapid stimulus rates to distinguish whether the generators of the negative potentials were of neural or receptor origin. Adaptation in controls resulted in amplitude reduction of CAP twice that of SP without affecting the duration of ECochG potentials. In seven AN ears without CAP and with prolonged negative potential, adaptation was accompanied by reduction of both amplitude and duration of the negative potential to control values consistent with neural generation. In four ears without CAP and with normal duration potentials, adaptation was without effect consistent with receptor generation. In five AN ears with CAP, there was reduction in amplitude of CAP and SP as controls but with a significant decrease in response duration. Conclusions: Three patterns of cochlear potentials were identified in AN: (1) presence of receptor SP without CAP consistent with presynaptic disorder of inner hair cells; (2) presence of both SP and CAP consistent with post-synaptic disorder of proximal auditory nerve; (3) presence of prolonged neural potentials without a CAP consistent with post-synaptic disorder of nerve terminals. Significance: Cochlear potential measures may identify pre-and post-synaptic disorders of inner hair cells and auditory nerves in AN.

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Section: Adaptation Of Ecochg Potentials In Controlssupporting

confidence: 63%

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Santarelli

Starr

Michalewski

et al. 2008

Clinical Neurophysiology

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“…Many animal studies on adaptation of auditory nerve and/or recovery therefrom have been reported, most of which have involved eliciting responses from single units of the auditory nerve using peristimulatory adaptation technique [7,8] or forward-masking protocols [5,9,10]. We previously studied AP recovery using a pairedclick stimulation paradigm in humans with normal hearing, and confirmed the presence of a relative refractory effect and short-term adaptation [1]. We subsequently identified the presence of abnormal AP recovery (iR and dR) using the same stimulation method in patients with iSSNHL, and assumed that this indicated malfunction of synapses between dendrites of the afferent auditory nerves and IHCs [2].…”

Section: Discussionmentioning

confidence: 58%

“…The first click of the pair played the role of the conditioner (or masker), and the AP amplitude to the first click additionally served as the control for normalization of the second-click AP amplitude [1].…”

Section: Acoustic Stimulationmentioning

confidence: 99%

“…The AP amplitudes in response to the first and second clicks were measured as the height from the prestimulus baseline to the maximum negative peak (N 1 ), as depicted previously [1].…”

Section: Acoustic Stimulationmentioning

confidence: 99%

“…We previously used a paired-click stimulation paradigm to study the recovery from adaptation of the compound action potential (AP) (referred to henceforth as AP recovery) in normal-hearing subjects as a function of inter-click interval (ICI), and identified that the recovery of the second-click AP amplitude may reflect the relative refractoriness and short-term adaptation of the auditory nerve [1]. A subsequent study of AP recovery in 45 subjects with idiopathic sudden sensorineural hearing loss (iSSNHL) using the same stimulation method identified 15 ears showing abnormal AP recovery, of which 11 ears showed abnormally faster or increased AP recovery (relative to the normal range) and 4 ears had abnormally slower or decreased AP recovery [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic evaluation of electrocochleography in idiopathic sudden sensorineural hearing loss

Ohashi

Nishino

Arai

et al. 2011

Acta Oto-Laryngologica

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Photobiomodulation using low‐level 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat

Lee

Chung

et al. 2019

Journal of Biophotonics

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A certain degree of noise can cause hearing problems without a permanent change in the hearing threshold, which is called hidden hearing loss and results from partial loss of auditory synapses. Photobiomodulation (PBM) enhances neural growth and connections in the peripheral nervous systems. In this study, we assessed whether PBM could rescue cochlear synaptopathy after acoustic overexposure in rat. PBM was performed for 7 days after noise exposure. The auditory brainstem responses (ABRs) were acquired before and after noise exposure using a tone and a paired‐click stimulus. Auditory response to paired click sound with short time interval was performed to evaluate auditory temporal processing ability. In the result, hearing threshold recovered 2 weeks after noise exposure in both groups. Peak wave 1 amplitude of the ABR and ABR recovery threshold did not recover in the noise only group, whereas it fully recovered in the noise + PBM group. The number of synaptic ribbons was significantly different in the control and noise only groups, while there was no difference between the control and noise + PBM group. These results indicate that PBM rescued peak wave 1 amplitude and maintained the auditory temporal processing ability resulting from a loss of synaptic ribbons after acoustic overexposure.

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Recovery of human compound action potential using a paired-click stimulation paradigm

Cited by 25 publications

References 33 publications

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Neural and receptor cochlear potentials obtained by transtympanic electrocochleography in auditory neuropathy

Prognostic evaluation of electrocochleography in idiopathic sudden sensorineural hearing loss

Photobiomodulation using low‐level 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat

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