Recommendations on Breast Cancer Screening and Prevention in the Context of Implementing Risk Stratification: Impending Changes to Current Policies

Abstract

In recent years, risk stratification has sparked interest as an innovative approach to disease screening and prevention. The approach effectively personalizes individual risk, opening the way to screening and prevention interventions that are adapted to subpopulations. The international perspective project, which is developing risk stratification for breast cancer, aims to support the integration of its screening approach into clinical practice through comprehensive tool-building. Policies and guidelines for risk stratification-unlike those for population screening programs, which are currently well regulated-are still under development. Indeed, the development of guidelines for risk stratification reflects the translational aspects of perspective.Here, we describe the risk stratification process that was devised in the context of perspective, and we then explain the consensus-based method used to develop recommendations for breast cancer screening and prevention in a risk-stratification approach. Lastly, we discuss how the recommendations might affect current screening policies.

Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes

“…Furthermore, such development supports the implementation of preventive strategies aiming to reduce the exposure to other known risk factors (e.g., early spaying recommendation and avoidance of hormonal anti-contraceptive therapy). 6,23 It is noteworthy that although most of the SNPs assessed in our study are not significantly associated with CMT risk, they may indeed influence the clinicopathologic features and biological behavior of the neoplastic disease, which are areas that deserve evaluation in future investigations.…”

Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management

“…A calculated risk of BC in these women is ranged from 20% to 29% based upon family history, personal health history, or certain genetic markers. Average-risk women (low-risk women) with none of the above risk factors have a 10-13% lifetime risk of BC [48]. Mammography screening in low-or intermediate-risk women aged less than 50 years is intensively discussed.…”

Possibilities of application of genetic and serum oncomarkers in early diagnostics of breast cancer

“…В 2013 г. был создан международный междисциплинарный исследовательский проект под названием «Персонализированная стратификация риска для профилактики и раннего выявления РМЖ», цель которого -разработка всеобъемлющего инструмента прогнозирования рисков развития РМЖ у женщин, рассчитанных на основании генетического исследования и некоторых других индивидуальных характеристик [55]. Связано это с тем, что в настоящее время в общепринятых клинических рекомендациях рассматриваются варианты воздействия только при очень высоком риске, таком как отягощенный семейный анамнез и клинически значимые мутации в генах BRCA1 и BRCA2.…”