Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages

Kazazi, Farhad; Mathijs, Jean Marie; Chang, Joon; Malafiej, Paul; López, Angel F.; Dowton, David; Sorrell, Tania C.; Vadas, MA; Cunningham, Anthony L.

doi:10.1099/0022-1317-73-4-941

Cited by 58 publications

(38 citation statements)

References 34 publications

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“…IL-10 should be added to other reported inhibitors of HIV in macrophages such as IFN-~, IFN-fl and both Th-1 (IFN-7, IL-13) and Th-2 (IL-4, IL-13) cytokines as potential mediators of viral latency in macrophages in vivo Poli & Fauci, 1992;Kazazi et al, 1992;Schuitemaker et al, 1992b). IL-4 and IFNy have also been reported to up-regulate HIV-1 within macrophages, yet undefined factors such as differences in culture conditions, timing of treatments, cytokine doses used, cell differentiation and donor variation have been proposed in explaining these variable effects.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

Montaner

Griffin

Gordon

1994

Journal of General Virology

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Section: Discussionmentioning

confidence: 99%

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

Montaner

Griffin

Gordon

1994

Journal of General Virology

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“…25,26 Monocytes were further depleted of contaminating cells by using a monocyte-enrichment cocktail (StemCell Technologies, Vancouver, BC, Canada). Monocyte fractions were at least 97% CD11c ϩve , at least 90% CD14 ϩve , and 0.1% or less CD3 ϩve .…”

Section: Mddc Generation and Culturementioning

confidence: 99%

HIV gp120 receptors on human dendritic cells

Turville

Arthos

Donald

et al. 2001

Blood

184

170

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Dendritic cells (DCs) are important targets for human immunodeficiency virus (HIV) because of their roles during transmission and also maintenance of immune competence. Furthermore, DCs are a key cell in the development of HIV vaccines. In both these settings the mechanism of binding of the HIV envelope protein gp120 to DCs is of importance. Recently a single C-type lectin receptor (CLR), DC-SIGN, has been reported to be the predominant receptor on monocyte-derived DCs (MDDCs) rather than CD4. In this study a novel biotinylated gp120 assay was used to determine whether CLR or CD4 were predominant receptors on MDDCs and ex vivo blood DCs. CLR bound more than 80% of gp120 on MDDCs, with residual binding attributable to CD4, reconfirming that CLRs were the major receptors for gp120 on MDDCs. However, in contrast to recent reports, gp120 binding to at least 3 CLRs was observed: DC-SIGN, mannose receptor, and unidentified trypsin resistant CLR(s) . IntroductionDendritic cells (DCs) play a major role in human immunodeficiency virus (HIV) pathogenesis. Peripheral or surveillance mucosal DCs are one of the first cell types infected and are distributed in the vaginal, ectocervical, and anal mucosa, 1,2 allowing contact with HIV during mucosal exposure. Thus, after vaginal inoculation with simian immunodeficiency virus in macaques, DCs are the predominant cell type infected. 3 Furthermore, the ability of DCs to cluster with and stimulate T cells may also play a key role in establishing infection. DCs from skin, mucosa, and blood of humans and macaques can participate in highly productive HIV and simian immunodeficiency virus infection in DC-T-cell cocultures and illustrates the importance of this natural DC-T-cell synergy. [4][5][6][7] Key aspects of HIV binding to DC via gp120 are ill-defined, particularly to the different types of DCs. CD11c ϩve and CD11c Ϫve blood DCs, Langerhans cells (LCs), and in vitro-derived monocytederived DCs (MDDCs) all express CD4 and CCR5 and can be productively infected in vitro. [8][9][10][11][12] However, HIV also bound several DC populations independently of CD4. 8,13,14 The heavy glycosylation of gp120 with mannose and fucose saccharides suggested HIV bound to cells also via lectin receptors. Binding of gp120 to a novel C-type lectin receptor (CLR), originally identified from a placental complementary DNA (cDNA) library 15 on the basis of HIV gp120 binding and named clone 11, on MDDCs was recently reported. 14,16 The adhesion properties of this CLR were also defined and the receptor subsequently renamed DC-SIGN (dendritic cell specific ICAM-3 grabbing nonintegrin). Although MDDCs express a diverse and abundant array of CLRs in addition to DC-SIGN, [16][17][18][19][20][21][22][23][24] and given substantial overlap in saccharide recognition by such CLRs, they may also serve as receptors for gp120 on MDDCs. The roles of CD4 and CLRs on most other in vivo DC types are unknown.This study aimed to define the contributions of CD4 and CLRs in binding gp120, to address and identify the capacity o...

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“…Recently we and others (Kazazi et al, 1991 ;Novak et al, 1990) showed that interleukin 4 (IL-4) could stimulate replication of human immunodeficiency virus (HIV) in human monocytes cultured in vitro without exogenous macrophage colony-stimulating factor (M-CSF), but only when added after HIV inoculation. Addition of IL-4 prior to HIV inoculation had either no effect [48 h, moderate concentrations (Kazazi et al, 1991)] or inhibited HIV replication [5 days, high concentrations (Schuitemaker et al, 1992)].…”

mentioning

confidence: 99%

Interleukin 4 and human immunodeficiency virus stimulate LFA-1-ICAM-1-mediated aggregation of monocytes and subsequent giant cell formation

Kazazi

Chang

López

et al. 1994

Journal of General Virology

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Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages

Cited by 58 publications

References 34 publications

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

HIV gp120 receptors on human dendritic cells

Interleukin 4 and human immunodeficiency virus stimulate LFA-1-ICAM-1-mediated aggregation of monocytes and subsequent giant cell formation

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