Recombinant bovine somatotropin is growth promoting and lipolytic in fattening lambs

Pullar, R.A.; Johnsson, I. D.; Chadwick, P. M. E.; Hart, I. C.

doi:10.1017/s0308229600015154

Cited by 4 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present experiment, biosynthetic somatotropin caused marked, dose-related reductions in the weight of both visceral and carcass fat depots but had little anabolic effect on muscle tissue. More conclusive is the recent preliminary finding that 0-1 mg/kg per day of the same preparation of biosynthetic somatotropin increased live-weight gain proportionately by 0-30 over a 6-week period in ram lambs (Pullar, Johnsson, Chadwick and Hart, 1986). per mg).…”

mentioning

confidence: 94%

The effects of dose and method of administration of biosynthetic bovine somatotropin on live-weight gain, carcass composition and wool growth in young lambs

Johnsson¹,

Hathorn²,

Wilde

et al. 1987

Anim. Sci.

View full text Add to dashboard Cite

1987). The effects of dose and method of administration of biosynthetic bovine somatotropin on live-weight gain, carcass composition and wool growth in young lambs. ABSTRACT Exogenous bovine pituitary somatotropin (GH) can influence markedly body composition in fattening lambs. However, neither the effects of biosynthetic somatotropin nor the effects of dose and method of administration have been reported. Fifty Dorset-cross lambs (female and castrated male) were given concentrate ad libitum and treated between 10 and 22 weeks of age with biosynthetic bovine somatotropin either dissolved in buffer and injected subcutaneously (s.c.) in proportion to body weight (0-025, 0-1 or 0-25 mg/kg per day), dissolved in buffer and continuously infused s.c. (0-1 mg/kg per day) or suspended in olive oil and injected s.c. (0-1 mg/kg per day), and compared with 10 untreated control lambs. Somatotropin had little effect on live-weight gain (controls = 228 g/day; final live weight 37 kg), food intake and food conversion efficiency, and only marginally increased the weight of muscle and bone dissected from the shoulder joint. The weights of the major fat depots in the abdominal cavity and of fat dissected from the shoulder joint were linearly related to dose of somatotropin (P < 0-001). Lambs given the highest dose had less visceral fat (1-18 v. 2-84 kg; P < 0-001) and proportionately less fat (285 v. 374 g/kg; P < 0-001) and more muscle (542 v. 447 g/kg) and bone (172 v. 149 g/kg; P < 0-001) in the shoulder joint than control lambs. There was a positive curvilinear relationship (P < 0-01) between clean wool growth (mid-side patch sample) and dose; lambs injected daily with 0-1 mg somatotropin per kg grew one-third more wool than control lambs. Method of administration affected plasma somatotropin profiles but had no significant influence on any of the responses measured. The anabolic actions of somatotropin may have been limited in this experiment by a low sodium concentration in the diet. It is concluded that the lipolytic/anti-lipogenic effect of somatotropin can occur in the absence of conditions conducive to the stimulation of muscle protein deposition and that the response is dose dependent but not influenced by method of administration of the hormone.

show abstract

mentioning

confidence: 94%

The effects of dose and method of administration of biosynthetic bovine somatotropin on live-weight gain, carcass composition and wool growth in young lambs

Johnsson¹,

Hathorn²,

Wilde

et al. 1987

Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…DNA-derived bovine somatotropin (Pullar, Johnsson, Chadwick and Hart, 1986; Pell, SOMATOTROPIN (growth hormone) has been Blake, Buttle, Johnsson, Simmonds and shown to be essential for growth (see Hart Morrell, 1987) have been demonstrated and but its efficacy as a although in other trials no anabolic effects of growth promoter in sheep has not been recombinant DNA-derived bovine firmly established. Results from Wagner and somatotropin were observed (Johnsson, Veenhuizen (1978) indicated increased growth Hathorn, Wilde, Treacher and Butler-Hogg, rate upon somatotropin treatment but this 1987; Pell et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Effects of recombinant DNA-derived bovine somatotropin on growth, carcass characteristics and meat quality in lambs from three breeds

Sinnett-Smith

Woolliams²,

Warriss³

et al. 1989

Anim. Sci.

View full text Add to dashboard Cite

1989). Effects of recombinant DNA-derived bovine somatotropin on growth, carcass characteristics and meat quality in lambs from three breeds. Animal Production, 49, pp 281-289 ABSTRACT Purebred lambs from three breeds (East Friesland, Oxford and Texel) were fed to appetite and treated with recombinant DNA-derived bovine somatotropin (BST) at 005, 0-10 or 0-20 mg/kg per day or a placebo between 19 and 27 weeks of age.BST maintained growth over the later stages of treatment but did not affect average daily live-weight gain over the whole treatment period. Food intake was decreased and food conversion efficiency was improved by BST treatment. However, carcass weight and killing-out proportion were decreased by BST treatment in all breeds. Consistent breed differences were observed. Oxford lambs had higher live weights and carcass weights than the other breeds but no breed x treatment interactions were apparent. Ultrasonic backfat depth (mean of measurements at 13th rib and 3rd lumbar vertebra) was reduced by BST treatment in the Oxford (the fattest) and Texel lambs but not in the East Frieslands (the leanest). Ultrasonic muscle depth was not affected by BST; East Friesland lambs had considerably smaller muscle depth than the other breeds.In the loin joint, BST decreased fat cover and subcutaneous fat proportion and increased longissimus dorsi proportion. There were also marked breed differences with Oxfords fatter than the other breeds. BST treatment did not affect any of the meat quality indicators but some differences between breeds were apparent in ultimate pH and colour of the muscle. Fatty acid composition of the subcutaneous fat was affected by breed but not by BST. East Friesland lambs had higher concentrations of unsaturated and branched chain fatty acids than the other breeds.A mammogenic response (increased mammary development and some secretory activity) to BST was observed in some female East Friesland and Texel lambs but not in Oxford lambs.

show abstract

“…Treatment of pigs with porcine GH increased carcass protein (Chung et al 1985), and in a study using bovine GH in lambs, significant increases were obtained in muscle mass after treatment , whereas another study using intact male lambs showed no significant increase in the proportion of pro¬ tein in the carcass after bovine GH treatment despite a significant increase in growth rate (Pullar et al 1986). Others have found only a small effect on muscle gain in lambs (Muir et al 1983;Johnsson et al 1987).…”

Section: Introductionmentioning

confidence: 99%

“…Treat¬ ment of pigs with recombinant DNA-derived human GH (Baile, Delia-Fera & McLaughlin, 1983) or with pituitary-derived porcine GH (Chung, Etherton & Wiggins, 1985;McLaren, Easter, Novakofski et al 1988) increased growth rate. In lambs some studies have shown an effect on weight gain after treatment with pituitary bovine GH (Johnsson, Hart & ButlerHogg, 1985) or with recombinant bovine GH (rbGH) (Pullar, Johnsson & Chadwick, 1986). However, other studies by the same group and others found no sig¬ nificant effect of rbGH on growth rates (Johnsson, Hathorn, Wilde et al 1987;Sinnett-Smith, Woolliams, Warriss & Enser, 1989).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of exogenous growth hormone on growth and body composition in genetically selected mice

Bootland

Hill²,

Sinnett-Smith³

1991

Journal of Endocrinology

View full text Add to dashboard Cite

The effects of exogenous GH on growth and body composition were investigated in lines of mice selected for high or low body weight (P-lines) or high or low body fat (F-lines). Mice from all lines were given daily injections of recombinant bovine GH or a placebo for 21 days from 4 weeks old. They were killed and various organ weights measured. There was no consistent effect of GH on organ weights. In all lines of mice the rate of weight gain and final weight increased in response to GH. In both lines selected for body fat, GH treatment decreased fat content. The low body weight mice also became less fat, but in the high body weight mice GH treatment increased fat percentage. The results indicate that the differences in growth rate and body composition observed in these lines are not due to differences in responsiveness to GH.

show abstract

Recombinant bovine somatotropin is growth promoting and lipolytic in fattening lambs

Cited by 4 publications

References 2 publications

The effects of dose and method of administration of biosynthetic bovine somatotropin on live-weight gain, carcass composition and wool growth in young lambs

The effects of dose and method of administration of biosynthetic bovine somatotropin on live-weight gain, carcass composition and wool growth in young lambs

Effects of recombinant DNA-derived bovine somatotropin on growth, carcass characteristics and meat quality in lambs from three breeds

Effects of exogenous growth hormone on growth and body composition in genetically selected mice

Contact Info

Product

Resources

About