Reclassification of Acute Myeloid Leukemia According to the 2016 WHO Classification

Abstract

We reviewed our leukemia database to reclassify 610 patients previously diagnosed as having acute myeloid leukemia (AML) according to the updated 2016 WHO classification. Nine patients were categorized as having myelodysplastic syndrome and myeloid neoplasms with germline predisposition. AML with recurrent genetic abnormalities accounted for 57.4% (345/601) of the patients under the 2016 WHO classification. AML with mutated NPM1 was the most common form (16.5%), with the majority associated with monocytic differentiation (63.6%). AML with double CEBPA mutations accounted for 8.3% of these cases, and the majority were previously diagnosed as AML with/without maturation (78.0%). These newly classified mutations were mutually exclusive without overlapping with other forms of AML with recurrent genetic abnormalities. AML with mutated NPM1 and AML with myelodysplasia-related changes comprised the oldest patients, whereas AML with RUNX1-RUNX1T1 included the youngest patients. The leukocyte count was highest in AML with mutated NPM1 , and the percentage of peripheral blood blasts was the highest in AML with double CEBPA mutations. Our results indicate that implementation of the 2016 WHO classification of AML would not pose major difficulties in clinical practice. Hematopathologists should review and prepare genetic tests for the new classification, according to their clinical laboratory conditions.

Changing the frequency and spectra of chromosomal aberrations in Korean patients with acute leukemia in a tertiary care hospital

“…The occurrence rate was higher compared to data from other institutes of Korea (6.7%), Caucasian (6.5. 10%), Australian (12%), Japanese (11%), and Singapore-Chinese (11%), but it was analogous to the Chinese data (14.3%) [5,6,13]. This discrepancy may be due to the sample size and likely to ethnic differences.…”

Leucemia Mieloide E Linfoide: Taxa De Mortalidade No Estado Do Pará-Brasil Entre Os Anos De 2000 E 2017

“…Além disso, podem ser subdivididas em agudas e crônicas, onde a aguda apresenta uma linhagem celular mais imatura no sangue periférico em relação à crônica. Já em células normais, a linhagem mieloide dá origem aos eritrócitos, monócitos, neutrófilos, eosinófilos, basófilos e plaquetas, e a linhagem linfoide origina os linfócitos B e T (JUNG et al,2019).…”

Revised World Health Organization Criteria-Defined Acute Myeloid Leukemia in a Large Cohort: Highlighting the Frequency and Characterization of Recategorized Cases

“…Since the publication of the revised 2016 WHO criteria, several studies have been undertaken on AML reclassi cation [4][5][6][7][8][9]. Half of these studies have investigated erythroleukemia or erythroiddominant AML, the subtype that underwent critical changes in the revised criteria [4,6,7].…”