Recipient site preparation by cryoblebbing in melanocyte keratinocyte transplantation procedure over the fingers in vitiligo: A pilot study

Hawary, Marwa El; Bassiouny, Dalia Ahmed; Esmat, Samia; Sobhi, Rehab Mohamed; Saleh, Marwah Adly; Abdel-Halim, Dalia; Hegazy, Rehab A.; Gawdat, Heba I.; Ragab, Nanis; Samir, Nesrin; Sany, Iman

doi:10.1111/dth.14199

Cited by 6 publications

(7 citation statements)

References 13 publications

(19 reference statements)

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“…18 In a recent study comparing cryoblebbing, and CO 2 laser resurfacing followed by melanocyte keratinocyte transplantation, and mini punch grafting (MPG) over fingers in nonsegmental vitiligo showed superior efficacy of cryoblebbing over other two procedures. 19 In our study, dermabrasion and cryoblister produced excellent (90%) and moderate repigmentation (62.5%) in the difficult-to-treat acral areas, respectively. All three interventions in our study were done predominantly over acral areas indicating that the acral patches are more resistant to the medical therapies and hence require surgical modality of treatment for inducing repigmentation.…”

Section: Resultssupporting

confidence: 50%

“…In a comparative study of cryoblister and CO 2 laser in NCES, comparable pigmentation was seen with both methods but cryoblister was found to be more effective than CO 2 laser in acral areas 18 . In a recent study comparing cryoblebbing, and CO 2 laser resurfacing followed by melanocyte keratinocyte transplantation, and mini punch grafting (MPG) over fingers in nonsegmental vitiligo showed superior efficacy of cryoblebbing over other two procedures 19 . In our study, dermabrasion and cryoblister produced excellent (90%) and moderate repigmentation (62.5%) in the difficult‐to‐treat acral areas, respectively.…”

Section: Discussionmentioning

confidence: 99%

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A prospective, randomized clinical study to compare the efficacy of recipient site preparation using dermabrasion, cryoblister, and dermaroller in autologous noncultured epidermal cell suspension in stable vitiligo

Subburaj

Thakur

Kumaran

et al. 2020

Dermatologic Therapy

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Noncultured epidermal cell suspension (NCES) is a well‐established surgical treatment modality for stable vitiligo. The outcome of this procedure significantly depends on the method of recipient site preparation, a critical step to achieve cosmetically acceptable repigmentation. To compare the efficacy of recipient site preparation using three methods namely, dermabrasion, cryoblister, and dermaroller followed by NCES in stable vitiligo. In this single‐center, prospective, intra‐patient, randomized clinical trial; 36 participants having at least three vitiligo patches in same anatomic region with minimum lesional stability of 1 year were randomized 1:1:1 for recipient site preparation using manual dermabrasion, cryoblister, and dermaroller followed by NCES. Patients were followed up at 4, 8, and 12 weeks and assessment of extent and pattern of repigmentation, color match and patient satisfaction were done. Among 36 patients, 22 (61.1%) were females; mean (SD) age was 28.33 (9.4) years. Dermabrasion and cryoblister techniques showed equal efficacy with respect to extent of repigmentation (>75% repigmentation; 55.6% vs 47.2%; P = .63) and patient satisfaction score (20.2 ± 9.6 vs 19.9 ± 7.9, P = .194). However, dermabrasion was superior to cryoblister in terms of rapidity (65% vs 32.5% at 4 weeks, P = .04) and color match (47.2% vs 19.4%, P = .004). Dermaroller had poor repigmentation outcomes compared to both dermabrasion and cryoblister. Cryoblister as a method of recipient site preparation is equally effective as manual dermabrasion in NCES for attaining good to excellent repigmentation, but with risk of hyperpigmentation. However, dermaroller is inferior to both dermabrasion and cryoblister.

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Section: Resultssupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

A prospective, randomized clinical study to compare the efficacy of recipient site preparation using dermabrasion, cryoblister, and dermaroller in autologous noncultured epidermal cell suspension in stable vitiligo

Subburaj

Thakur

Kumaran

et al. 2020

Dermatologic Therapy

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“…Thus, it combines the ease of the latter and the function of the former 39 . However, this technique is slower and is associated with post procedure pain, which may limit its practical use 40 …”

Section: Recipient Site Preparationmentioning

confidence: 99%

Transplantation procedures in vitiligo: What's new

Thakur

Parsad

2022

Dermatological Reviews

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Background: Transplantation plays a pivotal role in vitiligo surgery and has advanced at a galloping pace.Objectives: To enlist the latest developments in vitiligo transplantation surgery.Findings: Advancements in clinico-epidemiological and molecular profiling (CD8, CD45RO, CXCL-9) have enabled us to predict response to treatment better than ever before. The pace of transplantation has been augmented and the hassle of properly orienting the graft has been bypassed. The pallet has been expanded with a better donor to recipient ratio and ease of technique with regard to hair follicle transplants and suspensions. Suspending media have had a makeover, becoming less runner with a greater rate of pigmentation. Science has made the procedure more pocket and equipment friendly, be it in the realm of incubation or inhibition of trypsin. Electrofulguration, cryogens, salicylic and lactic acid, dental burrs, and lasers have made recipient site preparation easier. Adversity has been metamorphosed into an advantage by harvesting and transplanting the cobblestone that appears post-mini-punch grafting. Surgical techniques have been crafted to conform to special sites like the fingers, palmoplantar sites, ears, genitals, and nipple-areola. Conclusion:There have been many significant advancements in the field of vitiligo transplantation surgery in recent years especially in terms of ease of technique, minimal invasiveness, the pain associated with the procedure, and success rates.

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“…Fluorouracil is considered a cell cycle-specific for the S-phase of cell division. Activity results from its conversion to an active metabolite in the tissues and includes inhibition of DNA and RNA synthesis [3] .…”

Section: Introductionmentioning

confidence: 99%

“…One is that the drug produces melanocytes colonization in the vitiliginous epidermis by stimulating the division of epidermal melanocytes that migrate into the affected areas after epithelialization of the epidermis occurs. The second proposed that, the melanocytes responsible for repigmentation in vitiligo may be derived from the hair follicles [3] .…”

Section: Introductionmentioning

confidence: 99%

Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

Razek

Obaid

Elshahat

2021

International Journal of Medical Arts

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Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5-FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5-FU as a side effect in the skin tumors and psoriasis treatment The Aim of the work: Comparison between the efficacy of topical latanoprost versus topical 5-fluorouracil after skin dermabrasion in induction of skin repigmentation in stable non-segmental vitiligo. Patients and Methods: This study included thirty Egyptian patients, 18-60 years old, with stable non-segmental vitiligo. They were divided into: group [A] patients subjected to 5 fluorouracil after dermabrasion and group [B] patientssubjected to latanoprost after dermabrasion then followed up every two weeks for three months.Result: There was no statistically significant difference between both groups regarding total response to treatment and degree of repigmentation. However, there was higher response to treatment in group A than group B. In both groups patients were satisfied with the degree of improvement. As regard complication there were minimal complications only one case of koebnerization and two cases of post inflammatory hyperpigmentation Conclusion: 5-fluorouracil 5% was associated with better improvement than latanoprost. However, the difference did not reach statistical significance. Patients reported high satisfaction with the two treatment modalities.

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Recipient site preparation by cryoblebbing in melanocyte keratinocyte transplantation procedure over the fingers in vitiligo: A pilot study

Cited by 6 publications

References 13 publications

A prospective, randomized clinical study to compare the efficacy of recipient site preparation using dermabrasion, cryoblister, and dermaroller in autologous noncultured epidermal cell suspension in stable vitiligo

A prospective, randomized clinical study to compare the efficacy of recipient site preparation using dermabrasion, cryoblister, and dermaroller in autologous noncultured epidermal cell suspension in stable vitiligo

Transplantation procedures in vitiligo: What's new

Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

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