Receptor binding activities of Chlorella on cysteinyl leukotriene CysLT, glutamate AMPA, ion channels, purinergic P<sub>2Y</sub>, tachykinin NK<sub>2</sub> receptors and adenosine transporter

Cheng, Fang; Feng, Jin-Jye; Chen, Kuo-Hsin; Imanishi, Hideyo; Fujishima, Masaki; Takekoshi, Hideo; Naoki, Yo; Shimoda, Minoru

doi:10.1002/ptr.2864

Cited by 3 publications

(1 citation statement)

References 37 publications

(42 reference statements)

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“…Hence, it is possible that interplay between leukotriene and AMPA receptors also plays a role in the observed involvement of the 5-LOX system in cocaine actions and that leukotriene receptor-mediated events are involved in modifications of the GluR1 AMPA receptors observed in our studies. Interestingly, when the receptor activity and affinity of a natural product, Chlorella, were tested in 129 in vitro binding assay systems, it was observed that this compound acts on both leukotriene CysLT receptors and glutamate AMPA receptors (Cheng et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice

Chen

Manev

2011

Neuropharmacology

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In wild-type (WT) mice, the antibiotic minocycline inhibits development of cocaine-induced locomotor sensitization. Some of the actions of minocycline may involve the 5-lipoxygenase (5-LOX) pathway. We used the model of 5-LOX-deficient mice to investigate whether 5-LOX participates in minocycline’s influence on the effects of cocaine. Locomotor sensitization was induced by 4 daily cocaine injections and the phosphorylation status of GluR1 glutamate receptors was assayed in brain samples. Minocycline failed to affect cocaine sensitization in 5-LOX-deficient mice. In these mice, neither cocaine nor minocycline 4-day treatment altered GluR1 phosphorylation. In WT mice in which minocycline inhibited development of cocaine sensitization, a 4-day cocaine treatment increased GluR1 phosphorylation at both Ser831 and Ser845 sites in the frontal cortex but not the striatum; further, this effect was prevented by minocycline. Under basal conditions and in response to a single cocaine injection the levels of GluR1, GluR2, and GluR3 AMPA receptor subunits did not differ between WT and 5-LOX-deficient mice, but the response of GluR1 phosphorylation to a single cocaine injection was greater under the 5-LOX deficiency. Hence, in WT mice GluR1 phosphorylation increased only in the frontal cortex and only at the Ser831 site. In 5-LOX-deficient mice, acute cocaine injection increased both Ser831 and Ser845 phosphorylation both in the frontal cortex and in the striatum. We suggest that in studying minocycline’s action on cocaine’s effects and/or addiction in humans, it would be important to consider the characterization of the subjects’ 5-LOX system.

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Section: Discussionmentioning

confidence: 99%

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice

Chen

Manev

2011

Neuropharmacology

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Evolution of Purinergic Signalling

Burnstock

Verkhratsky

2012

Purinergic Signalling and the Nervous System

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Synthesis of Diverse Fused Tetracyclic Thiazepine-Chalcone Derivatives by Claisen-Schmidt Condensation Reaction and their Antimicrobial Activity

Hirani

Pandya

Koradiya³

2020

Asian J. Chem.

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To develop antimicrobial agent, a series of thiazepine-chalcones was synthesized by Claisen-Schmidt condensation between the couplings of aryl ketone in three steps protocol and different aromatic aldehydes under strong base catalyst at room temperature. The characterization of final products were carried out by IR, 1H & 13C NMR and elemental analysis. The synthesized compounds were also evaluated for their antibacterial and antifungal activities using specific Gram positive and Gram-negative bacterial strains using cup plate method.

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Receptor binding activities of Chlorella on cysteinyl leukotriene CysLT, glutamate AMPA, ion channels, purinergic P_2Y, tachykinin NK₂ receptors and adenosine transporter

Cited by 3 publications

References 37 publications

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice

Evolution of Purinergic Signalling

Synthesis of Diverse Fused Tetracyclic Thiazepine-Chalcone Derivatives by Claisen-Schmidt Condensation Reaction and their Antimicrobial Activity

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Receptor binding activities of Chlorella on cysteinyl leukotriene CysLT, glutamate AMPA, ion channels, purinergic P2Y, tachykinin NK2 receptors and adenosine transporter

Cited by 3 publications

References 37 publications

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice

Evolution of Purinergic Signalling

Synthesis of Diverse Fused Tetracyclic Thiazepine-Chalcone Derivatives by Claisen-Schmidt Condensation Reaction and their Antimicrobial Activity

Contact Info

Product

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Receptor binding activities of Chlorella on cysteinyl leukotriene CysLT, glutamate AMPA, ion channels, purinergic P_2Y, tachykinin NK₂ receptors and adenosine transporter