To develop antimicrobial agent, a series of thiazepine-chalcones was synthesized by Claisen-Schmidt
condensation between the couplings of aryl ketone in three steps protocol and different aromatic
aldehydes under strong base catalyst at room temperature. The characterization of final products were
carried out by IR, 1H & 13C NMR and elemental analysis. The synthesized compounds were also
evaluated for their antibacterial and antifungal activities using specific Gram positive and Gram-negative
bacterial strains using cup plate method.
A series of tetracyclic thiazepine based pyrazoles (6a-j) have been
synthesized and evaluated for antibacterial and antifungal activities.
The newly synthesized compounds have been characterized by IR,
1H & 13C NMR, mass and elemental analyses. Compounds 6b (2-
OCH3) and 6c (4-OCH3) have shown promising antibacterial, and 6g
(3-NO2), 6f (2-NO2) and 6d (3,4-diOCH3) exhibited excellent an
antifungal activity against standard drugs.
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