Synthesis, Spectral Analysis and Antibacterial Screening of Tetracyclic Thiazepine Based Pyrazole Derivatives

Abstract

A series of tetracyclic thiazepine based pyrazoles (6a-j) have been synthesized and evaluated for antibacterial and antifungal activities. The newly synthesized compounds have been characterized by IR, 1H & 13C NMR, mass and elemental analyses. Compounds 6b (2- OCH3) and 6c (4-OCH3) have shown promising antibacterial, and 6g (3-NO2), 6f (2-NO2) and 6d (3,4-diOCH3) exhibited excellent an antifungal activity against standard drugs.