Recent results of the searches for Supersymmetry in final states with one or two leptons at CMS are presented. Many Supersymmetry scenarios, including the Constrained Minimal Supersymmetric extension of the Standard Model (CMSSM), predict a substantial amount of events containing leptons, while the largest fraction of Standard Model background events -which are QCD interactions -gets strongly reduced by requiring isolated leptons. The analyzed data was taken in 2011 and corresponds to an integrated luminosity of approximately L = 1 fb −1 . The center-of-mass energy of the pp collisions was √ s = 7 TeV.

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Abstract:In order to reduce the potential radiation risk, low-dose CT has attracted an increasing attention. However, simply lowering the radiation dose will significantly degrade the image quality. In this paper, we propose a new noise reduction method for low-dose CT via deep learning without accessing original projection data. A deep convolutional neural network is here used to map low-dose CT images towards its corresponding normal-dose counterparts in a patch-by-patch fashion. Qualitative results demonstrate a great potential of the proposed method on artifact reduction and structure preservation. In terms of the quantitative metrics, the proposed method has showed a substantial improvement on PSNR, RMSE and SSIM than the competing state-of-art methods. Furthermore, the speed of our method is one order of magnitude faster than the iterative reconstruction and patch-based image denoising methods. for nuclei detection of breast cancer histopathology images," IEEE Trans.

The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that the three helical bundles R1–R3 in this region unfold in three distinct steps consistent with the domains unfolding independently. Mechanical stretching of talin R1–R3 enhances its binding to vinculin and vinculin binding inhibits talin refolding after force is released. Mutations that stabilize R3 identify it as the initial mechano-sensing domain in talin, unfolding at ∼5 pN, suggesting that 5 pN is the force threshold for vinculin binding and adhesion progression.

We study the process e + e − → π + π − J/ψ at a center-of-mass energy of 4.260 GeV using a 525 pb −1 data sample collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross section is measured to be (62.9 ± 1.9 ± 3.7) pb, consistent with the production of the Y (4260). We observe a structure at around 3.9 GeV/c 2 in the π ± J/ψ mass spectrum, which we refer to as the Zc(3900). If interpreted as a new particle, it is unusual in that it carries an electric charge and couples to charmonium. A fit to the π ± J/ψ invariant mass spectrum, neglecting interference, results in a mass of (3899.0 ± 3.6 ± 4.9) MeV/c 2 and a width 3 of (46 ± 10 ± 20) MeV. Its production ratio is measured to be R = σ(e + e − →π ± Zc(3900) ∓ →π + π − J/ψ)) σ(e + e − →π + π − J/ψ) = (21.5 ± 3.3 ± 7.5)%. In all measurements the first errors are statistical and the second are systematic. PACS numbers: 14.40.Rt, 14.40.Pq, 13.66.Bc Since its discovery in the initial-state-radiation (ISR) process e + e − → γ ISR π + π − J/ψ [1], and despite its subsequent observations [2][3][4][5], the nature of the Y (4260) state has remained a mystery. Unlike other charmonium states with the same quantum numbers and in the same mass region, such as the ψ (4040) A similar situation has recently become apparent in the bottomonium system above the BB threshold, where there are indications of anomalously large couplings between the Υ(5S) state (or perhaps an unconventional bottomonium state with similar mass, the Y b (10890)) and the π + π − Υ(1S, 2S, 3S) and π + π − h b (1P, 2P ) final states [14,15]. More surprisingly, substructure in these π + π − Υ(1S, 2S, 3S) and π + π − h b (1P, 2P ) decays indicates the possible existence of charged bottomoniumlike states [16], which must have at least four constituent quarks to have a non-zero electric charge, rather than the two in a conventional meson. By analogy, this suggests there may exist interesting substructure in the Y (4260) → π + π − J/ψ process in the charmonium region.In this Letter, we present a study of the process e + e − → π + π − J/ψ at a center-of-mass (CM) energy of √ s = (4.260± 0.001) GeV, which corresponds to the peak of the Y (4260) cross section. We observe a charged structure in the π ± J/ψ invariant mass spectrum, which we refer to as the Z c (3900). The analysis is performed with a 525 pb −1 data sample collected with the BESIII detector, which is described in detail in Ref. [17]. In the studies presented here, we rely only on charged particle tracking in the main drift chamber (MDC) and energy deposition in the electromagnetic calorimeter (EMC).The GEANT4-based Monte Carlo (MC) simulation software, which includes the geometric description of the BE-SIII detector and the detector response, is used to optimize the event selection criteria, determine the detection efficiency, and estimate backgrounds. For the signal process, we use a sample of e + e − → π + π − J/ψ MC events generated assuming the π + π − J/ψ is produced via Y (4260) decays, and using the...

Heat-stable nucleoid structuring protein (H-NS) is an abundant prokaryotic protein that plays important roles in organizing chromosomal DNA and gene silencing. Two controversial binding modes were identified. H-NS binding stimulating DNA bridging has become the accepted mechanism, whereas H-NS binding causing DNA stiffening has been largely ignored. Here, we report that both modes exist, and that changes in divalent cations drive a switch between them. The stiffening form is present under physiological conditions, and directly responds to pH and temperature in vitro. Our findings have broad implications and require a reinterpretation of the mechanism by which H-NS regulates genes.

The decay J/ψ → ωpp has been studied, using 225.3 × 10 6 J/ψ events accumulated at BESIII. No significant enhancement near the pp invariant-mass threshold (denoted as X(pp)) is observed. The upper limit of the branching fraction B(J/ψ → ωX(pp) → ωpp) is determined to be 3.9 × 10 −6 at the 95% confidence level. The branching fraction of J/ψ → ωpp is measured to be B(J/ψ → ωpp) = (9.0 ± 0.2 (stat.) ± 0.9 (syst.)) × 10 −4 . 124The investigation of the near-threshold pp invariant 125 mass spectrum in other J/ψ decay modes will be helpful 126 in understanding the nature of the observed structure. 127The decay J/ψ → ωpp restricts the isospin of the pp 128 system, and it is helpful to clarify the role of the pp in the return iron yoke of the superconducting magnet. 174The position resolution is about 2 cm. 175The optimization of the event selection and the es- 247The branching fraction of J/ψ → ωpp is calculated 248 according to :(1) where N obs is the number of signal events determined Breit-Wigner function :Here, q is the momentum of the proton in the pp rest where N obs is the number of signal events, and L is the Author's Copy where σ sys. is the total systematic uncertainty which will 299 be described in the next section. The upper limit on the 300 product of branching fractions is B(J/ψ → ωX(pp) → 301 ωpp) < 3.9 × 10 −6 at the 95% C.L.. 302An alternative fit with a Breit-Wigner function includ-for X(pp) is performed. Here, f FSI is the Jülich FSI cor- between data and MC simulation is 2% per charged track. 323The systematic uncertainty from PID is 2% per proton 324(anti-proton). 325The photon detection systematic uncertainty is studied efficiency difference is about 1% for each photon [32, 33]. 329Author's Copy Near-threshold pp invariant-mass spectrum. The signal J/ψ → ωX(pp) → ωpp is described by an acceptanceweighted Breit-Wigner function, and and signal yield is consistent with zero. The dotted line is the shape of the signal which is normalized to five times the estimated upper limit. The dashed line is the non-resonant contribution described by the function f (δ) and the dashed-dotted line is the non ωpp contribution which is estimated from ω sidebands. The solid line is the total contribution of the two components. The hatched area is from the sideband region.Here, 3% is taken as the systematic error for the efficien- ciency between data and MC is 3%, and is taken as the 338 systematic uncertainty caused by the kinematic fit. 339As described above, the yield of J/ψ → ωpp is de- The signal J/ψ → ωX(pp) → ωpp is described by an acceptanceweighted Breit-Wigner function, and and signal yield is consistent with zero. The dashed line is the non-resonant contribution fixed to a phase space MC simulation of J/ψ → ωpp and the dashed-dotted line is the non ωpp contribution which is estimated from ω sidebands. The solid line is the total contribution of the two components. The hatched area is from a phase space MC simulation of J/ψ → ωpp.sented by Figure.

Although magnetic tweezers have many unique advantages in terms of specificity, throughput, and force stability, this tool has had limited application on short tethers because accurate measurement of force has been difficult for short tethers under large tension. Here, we report a method that allows us to apply magnetic tweezers to stretch short biomolecules with accurate force calibration over a wide range of up to 100 pN. We demonstrate the use of the method by overstretching of a short DNA and unfolding/refolding a protein of filamin A immunoglobulin domains 1-8. Other potential applications of this method are also discussed.