Receptive Field Mosaics of Retinal Ganglion Cells Are Established Without Visual Experience

Anishchenko, A. V.; Greschner, Martin; Elstrott, Justin; Sher, Alexander; Litke, A. M.; Feller, Marla B.; Chichilnisky, E. J.

doi:10.1152/jn.00896.2009

Cited by 47 publications

(49 citation statements)

References 67 publications

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“…At the same time, the strength of light-evoked inputs to RGCs, both excitatory and inhibitory, decrease from eye opening through ϳP30 (He et al 2011). We found that latencies were long at eye opening, particularly for OFF cells, and decreased to near mature levels by P16 -17, similar to the results of other studies (Anishchenko et al 2010;Tian and Copenhagen 2003). The increase in RGC responsiveness with age is indicated by the increase in the maximum contrast of the linear filters.…”

Section: Discussionsupporting

confidence: 91%

“…Ideally, each RGC functional type would be followed through development to determine if individual classes go through unique developmental programs (Coombs et al 2007). In other studies, a large percentage of rodent RGCs responsive to white noise checkerboards were segregated into four functional classes by the characteristics of their STA time course (Anishchenko et al 2010;Kerschensteiner et al 2008). Although RGC functional groups could not be resolved by PCA in our study, we segregated RGC types into these four classes using ranges of linear filter parameters that appear to account for most of the variance that separates the groups (Kerschensteiner et al 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Receptive fields of RGCs were mapped by presenting Gaussian white noise checkerboards (Anishchenko et al 2010;Cantrell et al 2010;Chichilnisky 2001;Kerschensteiner et al 2008). Random 32 ϫ 32 checkerboard frames with a checker size of 120 m were displayed at a rate of 75 Hz, equivalent to 1 frame every 13.33 ms, to the retinas being recorded on the array.…”

Section: Mapping Rgc Receptive Field Center Area and Determining Intrmentioning

confidence: 99%

“…Kerschensteiner et al (2008) reported two ON types and two OFF types of mouse RGCs that accounted for 80% of the RGCs they recorded from C57Bl6 mouse retinas on a MEA. In the rat, these types accounted for 30 -60% of the RGCs recorded using a MEA (Anishchenko et al 2010). In both studies, PCA of linear filter parameters was used to identify clusters of filters, which represented the RGC functional types.…”

Section: Functionally Classifying Rgcsmentioning

confidence: 99%

“…The linear filter defines the stimulus time course that best drives RGC spiking. We determined latency to spiking as the zero-crossing time just before the linear filter reached peak STA contrast, a time of maximum response in the linear firing model (Anishchenko et al 2010). Latencies were longest at eye opening, became significantly shorter by P16 -17, and became shorter still by P30 -39 (Fig.…”

Section: Light Response Properties Develop After Eye Openingmentioning

confidence: 99%

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Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse

Koehler¹,

Akimov²,

Renterı́a

2011

Journal of Neurophysiology

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Mapping Rgc Receptive Field Center Area and Determining Intrmentioning

confidence: 99%

Section: Functionally Classifying Rgcsmentioning

confidence: 99%

Section: Light Response Properties Develop After Eye Openingmentioning

confidence: 99%

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Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse

Koehler¹,

Akimov²,

Renterı́a

2011

Journal of Neurophysiology

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Expression of transcription factors divides retinal ganglion cells into distinct classes

Sweeney

James

Nistorica

et al. 2017

J of Comparative Neurology

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Retinal ganglion cells (RGCs) are tasked with transmitting all light information from the eye to the retinal recipient areas of the brain. RGCs can be classified into many different types by morphology, gene expression, axonal projections, and functional responses to different light stimuli. Ultimately, these classification systems should be unified into an all-encompassing taxonomy. Toward that end, we show here that nearly all RGCs express either Islet-2 (Isl2), Tbr2, or a combination of Satb1 and Satb2. We present gene expression data supporting the hypothesis that Satb1 and Satb2 are expressed in ON-OFF direction-selective (DS) RGCs, complementing our previous work demonstrating that RGCs that express Isl2 and Tbr2 are non-DS and non-image-forming, respectively. Expression of these transcription factors emerges at distinct embryonic ages and only in postmitotic cells. Finally, we demonstrate that these transcription factor-defined RGC classes are born throughout RGC genesis.

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Developmental mechanisms that regulate retinal ganglion cell dendritic morphology

Tian

2011

Developmental Neurobiology

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One of the fundamental features of retinal ganglion cells (RGCs) is that dendrites of individual RGCs are confined to one or a few narrow strata within the inner plexiform layer (IPL), and each RGC synapses only with a small group of presynaptic bipolar and amacrine cells with axons/dendrites ramified in the same strata to process distinct visual features. The underlying mechanisms which control the development of this laminar-restricted distribution pattern of RGC dendrites have been extensively studied, and it is still an open question whether the dendritic pattern of RGCs is determined by molecular cues or by activity-dependent refinement. Accumulating evidence suggests that both molecular cues and activity-dependent refinement might regulate RGC dendrites in a cell subtype-specific manner. However, identification of morphological subtypes of RGCs before they have achieved their mature dendritic pattern is a major challenge in the study of RGC dendritic development. This problem is now being circumvented through the use of molecular markers in genetically engineered mouse lines to identify RGC subsets early during development. Another unanswered fundamental question in the study of activity-dependent refinement of RGC dendrites is how changes in synaptic activity lead to the changes in dendritic morphology. Recent studies have started to shed light on the molecular basis of activity-dependent dendritic refinement of RGCs by showing that some molecular cascades control the cytoskeleton reorganization of RGCs.

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Receptive Field Mosaics of Retinal Ganglion Cells Are Established Without Visual Experience

Cited by 47 publications

References 67 publications

Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse

Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse

Expression of transcription factors divides retinal ganglion cells into distinct classes

Developmental mechanisms that regulate retinal ganglion cell dendritic morphology

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