Recent update on XBB.1.5 emerging novel mutation of COVID-19

Amin, Ruhul; Pal, Prosanta; Dhama, Kuldeep; Emran, Talha Bin

doi:10.1097/js9.0000000000000254

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…The only exception is a rather rare substitution, F486P, which increases the affinity of the coronavirus S protein for the human ACE2 receptor. This substitution provides an advantage in reproduction and, consequently, increases the transmissibility [13].…”

Section: Introductionmentioning

confidence: 99%

Biological Properties of SARS-CoV-2 Omicron Variant Sublineages

Shipovalov,

Zaykovskaya,

Kudrov

et al. 2023

Preprint

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A change in biological properties of the SARS-CoV-2 virus can enhance its transmissibility and virulence, complicate the disease course, and reduce the effectiveness of anti-viral therapy and vaccination. We have studied 16 genetic lineages of the Omicron variant. The viral reproduction course was analyzed based on plaque morphology in the agar layer and the maximum titer in Vero E6 cells. BALB/c mice and Syrian hamsters were used as animal models. Viral load and infectious SARS-CoV-2 titer were determined in the nasal tissue and lungs. The severity of infectious process was assessed using histological methods. An increased plug size was observed in CH.1.1 and BQ.1.2.1 strains after six passages. This was due to substitutions D614G, H655Y, and N764K in the coronavirus S protein. The same changes in gene variants Gamma and BA.1 were caused by the substitution R682W, which is not present in lineages CH.1.1 and BQ.1.2.1. A similar substitution, namely R682P, was observed in the BA.5.1 strain. We characterized BA.1 (as a reference), BA.5.2, and XBB.3 strains in vivo as representatives of the main circulating genetic lineages. For the BA.1 strain, ID50 was 1.3 and 14 TCD50 in Syrian hamsters and BALB/c mice, respectively. An insignificant increase in the BA.5.2 virulence compared to that of BA.1 was noted (ID50 was 07. and 10 TCD50, respectively). The XBB.3 pathogenicity in laboratory animals is similar to that of BA.1 (ID50 was 1.8 and 15 TCD50, respectively). Experiments showed a consistent decrease in the virulence of Omicron strains compared to previously circulating SARS-CoV-2 variants. A co-evolutionary change in amino acid sequences, affecting the conformation of the coronavirus S protein and its surface epitopes in representatives of different genetic lineages, was noted. The emergence of potential proteolysis sites and alterations of the furin cleavage site have been observed in numerous Omicron coronavirus variants.

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Section: Introductionmentioning

confidence: 99%

Biological Properties of SARS-CoV-2 Omicron Variant Sublineages

Shipovalov,

Zaykovskaya,

Kudrov

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Besides a better understanding of this disease, developing efficacious vaccines, drugs and therapies are of utmost importance. Additionally, in-depth disease investigations, case management studies, adopting adequate infection prevention and control measures, risk communication, community engagement and enhancing awareness, and implementation of one health approach more effectively are all very crucial to counteract MARV transmission and spread before it could pose dangers of global public health concerns amid the ongoing Monkeypox global health emergency and COVID-19 pandemic 9 .…”

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confidence: 99%

Recent report of novel Marburg virus disease (MVD) outbreak across the world

Amin,

Chakraborty,

Saikumar

et al. 2023

International Journal of Surgery: Global Health

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“…According to an Indian study, 44% of COVID-19 patients admitted to ICUs exhibited C. auris colonisation, which was associated with a higher mortality rate [4] . In addition, a study done in Spain revealed that C. auris was the most prevalent fungus species detected in COVID-19 patients' respiratory samples in ICUs [5] .The coinfection of COVID-19 and C. auris poses a significant challenge to global healthcare systems [6] . C. auris infections may be difficult to treat and may need lengthy hospital stays, placing further strain on healthcare resources.…”

mentioning

confidence: 99%

“…The coinfection of COVID-19 and C. auris poses a significant challenge to global healthcare systems [6] . C. auris infections may be difficult to treat and may need lengthy hospital stays, placing further strain on healthcare resources.…”

mentioning

confidence: 99%

The emergence of a novel fungal disease Candida auris/COVID-19 coinfection

Amin,

Darwin,

Ahmed

et al. 2023

International Journal of Surgery: Global Health

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Candida auris is a novel fungus that has swiftly become a huge threat to global public health. This condition is difficult to treat because it may develop resistance to antifungal medications and spread quickly among vulnerable populations, such as those in hospitals [1] . The coronavirus disease 2019 (COVID-19) pandemic has exacerbated things by increasing the risk of infection and emphasising the need for infection prevention and control strategies [2] .The COVID-19 pandemic has had a significant role in the surge of C. auris infections. Patients with COVID-19 who are critically ill are more prone to secondary infections, especially fungal infections. The use of mechanical ventilation for an extended period of time, as well as the widespread use of broad-spectrum antibiotics, may promote the development of C. auris infections [3] .COVID-19 patients treated in intensive care units (ICUs) and hospitalised for lengthy periods of time exhibited a substantial prevalence of C. auris colonisation, according to studies. According to an Indian study, 44% of COVID-19 patients admitted to ICUs exhibited C. auris colonisation, which was associated with a higher mortality rate [4] . In addition, a study done in Spain revealed that C. auris was the most prevalent fungus species detected in COVID-19 patients' respiratory samples in ICUs [5] .The coinfection of COVID-19 and C. auris poses a significant challenge to global healthcare systems [6] . C. auris infections may be difficult to treat and may need lengthy hospital stays, placing further strain on healthcare resources. There is also the prospect of C. auris outbreaks in hospitals, which might be devastating for vulnerable patients.

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Recent update on XBB.1.5 emerging novel mutation of COVID-19

Cited by 4 publications

References 6 publications

Biological Properties of SARS-CoV-2 Omicron Variant Sublineages

Biological Properties of SARS-CoV-2 Omicron Variant Sublineages

Recent report of novel Marburg virus disease (MVD) outbreak across the world

The emergence of a novel fungal disease Candida auris/COVID-19 coinfection

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