Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

Abstract

As the most abundant natural flavonoid in rattan tea, dihydromyricetin (DMY) has shown a wide range of pharmacological effects. In addition to the general characteristics of flavonoids, DMY has the effects of cardioprotection, anti-diabetes, hepatoprotection, neuroprotection, anti-tumor, and dermatoprotection. DMY was also applied for the treatment of bacterial infection, osteoporosis, asthma, kidney injury, nephrotoxicity and so on. These effects to some extent enrich the understanding about the role of DMY in disease prevention and therapy. However, to date, we still have no outlined knowledge about the detailed mechanism of DMY, which might be related to anti-oxidation and anti-inflammation. And the detailed mechanisms may be associated with several different molecules involved in cellular apoptosis, oxidative stress, and inflammation, such as AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), protein kinase B (Akt), nuclear factor-κB (NF-κB), nuclear factor E2-related factor 2 (Nrf2), ATP-binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-γ (PPARγ) and so on. Here, we summarized the current pharmacological developments of DMY as well as possible mechanisms, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.

Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway

“…Nrf2 is a key transcription factor that regulates antioxidant genes (such as CAT, SOD and HO-1) by combining with antioxidant response elements 33 . It has been shown that the activation of Nrf2 is related to cisplatin, acetaminophen and aristolochic acid in drug-induced nephrotoxicity 34 . Similarly, in HEK293 cells, after SDAP treatment, Nrf2 and its corresponding downstream HO-1, NQO1 protein levels increased significantly (Fig.…”

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

“…[6,13]. is compound was found to possess anticholinesterase [6], antiatherosclerosis (anti-inflammatory), antidiabetes, and antitumor activities and effects on cardioprotection, hepatoprotection, neuroprotection, and dermatoprotection [14].…”

Metabolomics of the Protective Effect of Ampelopsis grossedentata and Its Major Active Compound Dihydromyricetin on the Liver of High‐Fat Diet Hamster

“…Dihydromyricetin (DMY), which is the main flavonoid of AG with a content of up to 35% [7], showed antiproliferation capacities in lung [8], breast, [9], and ovarian cancer [10], improvements on hypertension [11], hyperlipidemia [12,13] and abnormal blood sugar levels [14], as well as neuroprotective activity against Alzheimer's disease [15], Parkinson's disease [16], alcohol addiction, depression [17], and dermatoprotection [18]. In addition, a preventive effect on myocardial fibrosis [19], myocardial hypertrophy [20], and cardiac ischemia/reperfusion injury [21] was reported.…”