Recent understanding of human milk oligosaccharides in establishing infant gut microbiome and roles in immune system

Singh, Ravindra; Niharika, Jayashree; Kondepudi, Kanthi Kiran; Bishnoi, Mahendra; Tingirikari, Jagan Mohan Rao

doi:10.1016/j.foodres.2021.110884

Cited by 42 publications

(33 citation statements)

References 172 publications

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“…Macrophages and leukocytes from breast milk can kill enteropathogenic Escherichia coli, Giardia lamblia, Staphylococcus aureus, and Candida albicans , thus contributing to the gradual recovery of infants who have been breastfed ( Riskin et al., 2012 ). Breast milk contains compounds that may affect the immunity of newborns, including a group of oligosaccharides synthesised in the lactose gland, which is known as breast milk oligosaccharides (HMOs) ( Bode, 2012 ; Plaza-Diaz et al., 2018 ; Singh et al., 2022 ). HMOs directly modulate the intestinal immune response, ensure enrichment of the gut microbiome and regulate microbial adhesion, thus protecting breastfed infants from microbial infections ( Bode, 2012 ; Chichlowski et al., 2012 ; Singh et al., 2022 ).…”

Section: Infant Immune System Regulates the Composition Of Gut Microb...mentioning

confidence: 99%

“…Breast milk contains compounds that may affect the immunity of newborns, including a group of oligosaccharides synthesised in the lactose gland, which is known as breast milk oligosaccharides (HMOs) ( Bode, 2012 ; Plaza-Diaz et al., 2018 ; Singh et al., 2022 ). HMOs directly modulate the intestinal immune response, ensure enrichment of the gut microbiome and regulate microbial adhesion, thus protecting breastfed infants from microbial infections ( Bode, 2012 ; Chichlowski et al., 2012 ; Singh et al., 2022 ). HMOs can stimulate the growth of beneficial microorganisms, mainly Bifidobacterium genus and some strains of Bacteroides and Lactobacillus ( Sanchez et al., 2021 ).…”

Section: Infant Immune System Regulates the Composition Of Gut Microb...mentioning

confidence: 99%

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The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants

Zhang

Liao

et al. 2022

Front. Cell. Infect. Microbiol.

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The human gut microbiome is important for human health. The development of stable microbial communities in the gastrointestinal tract is closely related to the early growth and development of host immunity. After the birth of a baby, immune cells and the gut microbiome mature in parallel to adapt to the complex gut environment. The gut microbiome is closely linked to the immune system and influences each other. This interaction is associated with various diseases in infants and young children, such as asthma, food allergies, necrotizing colitis, obesity, and inflammatory bowel disease. Thus, the composition of the infant gut microbiome can predict the risk of disease development and progression. At the same time, the composition of the infant gut microbiome can be regulated in many ways and can be used to prevent and treat disease in infants by modulating the composition of the infant gut microbiome. The most important impacts on infant gut microbiota are maternal, including food delivery and feeding. The differences in the gut microbiota of infants reflect the maternal gut microbiota, which in turn reflects the gut microbiota of a given population, which is clinically significant.

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Section: Infant Immune System Regulates the Composition Of Gut Microb...mentioning

confidence: 99%

Section: Infant Immune System Regulates the Composition Of Gut Microb...mentioning

confidence: 99%

The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants

Zhang

Liao

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Both in vitro and in vivo studies have highlighted the ability of HMOs and HMO-compounds (i.e., 2′ -fucosyllactose) to modulate mucins expression and the secretory function of GCs ( 165 , 166 ). HMOs can directly control intestinal immunity by decoying receptors of pathogenic bacteria and viruses, thereby preventing their binding on intestinal cells and the onset of a disease ( 167 ). Transitioning from milk based to solid food, and the introduction of fiber to our diet, the pivotal metabolic substrate for the gut microbiota, induce the production of SCFAs.…”

Section: Dietary Patterns: the Determining Factor For The Intestinal ...mentioning

confidence: 99%

Diet, microbiota, and the mucus layer: The guardians of our health

et al. 2022

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The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors shaping the microbiome-host relationship. Diets high in fiber and low in fat and sugars, as opposed to Western and high-fat diets, have been shown to have a beneficial effect on intestinal health by promoting the growth of beneficial bacteria, improve mucus barrier function and immune tolerance, while inhibiting pro-inflammatory responses and their downstream effects. On the contrary, diets low in fiber and high in fat and sugars have been associated with alterations in microbiota composition/functionality and the subsequent development of chronic diseases such as food allergies, inflammatory bowel disease, and metabolic disease. In this review, we provided an updated overview of the current understanding of the connection between diet, microbiota, and health, with a special focus on the role of Western and high-fat diets in shaping intestinal homeostasis by modulating the gut microbiota.

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“…Human milk feeding has been shown to provide healthy gastrointestinal mucosal stimuli, which can help improve infants' immune systems [37] and also reduce the risk of infectious disease in infancy ]. Single-cell RNA sequencing (scRNA-seq) was used to profile transcriptome of the MEC in a randomized controlled trial with 59 diet-controlled women during early lactation who had gestational diabetes but normal lactation.…”

Section: Rna Sequencingmentioning

confidence: 99%

“…Human milk feeding has been shown to provide healthy gastrointestinal mucosal stimuli, which can help improve infants’ immune systems [37] and also reduce the risk of infectious disease in infancy [38 ▪▪ ]. Mammary epithelial cells (MEC) derived from milk samples have recently emerged as a noninvasive model system to evaluate lactation physiology [39 ▪▪ ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of human milk in the era of precision health

Dastmalchi

Jones

et al. 2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewPrecision health provides an unprecedented opportunity to improve the assessment of infant nutrition and health outcomes. Breastfeeding is positively associated with infant health outcomes, yet only 58.3% of children born in 2017 were still breastfeeding at 6 months. There is an urgent need to examine the application of precision health tools that support the development of public health interventions focused on improving breastfeeding outcomes.Recent findingsIn this review, we discussed the novel and highly sensitive techniques that can provide a vast amount of omics data and clinical information just by evaluating small volumes of milk samples, such as RNA sequencing, cytometry by time-of-flight, and human milk analyzer for clinical implementation. These advanced techniques can run multiple samples in a short period of time making them ideal for the routine clinical evaluation of milk samples.SummaryPrecision health tools are increasingly used in clinical research studies focused on infant nutrition. The integration of routinely collected multiomics human milk data within the electronic health records has the potential to identify molecular biomarkers associated with infant health outcomes.

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Recent understanding of human milk oligosaccharides in establishing infant gut microbiome and roles in immune system

Cited by 42 publications

References 172 publications

The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants

The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants

Diet, microbiota, and the mucus layer: The guardians of our health

Assessment of human milk in the era of precision health

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